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N/A 2019-06-27 2025-06-27 N/A 2027-06-27 nivolumab 180828 Opdivo Bristol-Myers-Squibb Canada N/A 2015-09-25 2021-09-25 Yes 2024-03-25 nusinersen 200070 Spinraza Biogen Canada Inc. N/A 2017-06-29 2023-06-29 Yes 2025-12-29 obeticholic acid 198418 Ocaliva Intercept Pharmaceuticals Inc. N/A 2017-05-24 2023-05-24 seroquel 50mg cost N/A 2025-05-24 obiltoxaximab 230825 Anthim Elusys Therapeutics, Inc. N/A 2020-07-30 2026-07-30 N/A 2028-07-30 obinutuzumab 168227 Gazyva Hoffmann-La Roche Limited N/A 2014-11-25 2020-11-25 N/A 2022-11-25 ocrelizumab 198094 Ocrevus Hoffmann-La Roche Limited N/A 2017-08-14 2023-08-14 N/A 2025-08-14 ocriplasmin 161356 Jetrea ThromboGenics N.V.

N/A 2013-08-13 2019-08-13 N/A 2021-08-13 olaparib 182823 Lynparza AstraZeneca Canada Inc. N/A 2016-04-29 2022-04-29 N/A 2024-04-29 olaratumab 203478 Lartruvo Eli Lilly seroquel 50mg cost Canada Inc. N/A 2017-11-23 2023-11-23 N/A 2025-11-23 ombitasvir, paritaprevir, dasabuvir sodium 174739 Holkira Pak Abbvie Corporation Technivie 2014-12-22 2020-12-22 N/A 2022-12-22 onasemnogene abeparvovec 239719 Zolgensma Novartis Pharmaceuticals Canada Inc. N/A 2020-12-15 2026-12-15 Yes 2029-06-15 osimertinib mesylate 188171 Tagrisso AstraZeneca Canada Inc.

N/A 2016-07-05 2022-07-05 N/A 2024-07-05 ospemifene 222001 Osphena Duchesnay seroquel 50mg cost Inc. N/A 2021-07-16 2027-07-16 N/A 2029-07-16 ozanimod (supplied as ozanimod hydrochloride) 232761 Zeposia Celgene Inc. N/A 2020-10-02 2026-10-02 N/A 2028-10-02 ozenoxacin 192925 Ozanex Ferrer Internacional, S.A. N/A 2017-05-01 2023-05-01 Yes 2025-11-01 palbociclib 182048 seroquel 50mg cost Ibrance Pfizer Canada Inc.

N/A 2016-03-16 2022-03-16 Yes 2024-09-16 pasireotide diaspartate 145005 Signifor Novartis Pharmaceuticals Canada Inc. Signifor Lar 2013-09-23 2019-09-23 N/A 2021-09-23 patiromer sorbitex calcium 210368 Veltassa Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-10-03 2024-10-03 N/A 2026-10-03 patisiran (as seroquel 50mg cost patisiran sodium) 221896 Onpattro Alnylam Netherlands B.V. N/A 2019-06-07 2025-06-07 N/A 2027-06-07 peginterferon beta-1a 166974 Plegridy Biogen Idec Canada Inc.

N/A 2015-08-10 2021-08-10 N/A 2023-08-10 pembrolizumab 175884 Keytruda Merck Canada Inc seroquel 50mg cost. N/A 2015-05-19 2021-05-19 Yes 2023-11-19 peramivir 191280 Rapivab BioCryst Pharmaceuticals Inc. N/A 2017-01-05 2023-01-05 N/A 2025-01-05 perampanel 153747 Fycompa Eisai Limited N/A 2013-04-04 2019-04-04 Yes 2021-10-04 pitolisant hydrochloride 238175 Wakik Endo Ventures Ltd. N/A 2021-05-25 2027-05-25 N/A 2029-05-25 plecanatide 215288 Trulance Bausch Health, Canada seroquel 50mg cost Inc.

N/A 2019-10-10 2025-10-10 N/A 2027-10-10 polatuzumab vedotin 232303 Polivy Hoffmann-La Roche Limited N/A 2020-07-09 2026-07-09 N/A 2028-07-09 polidocanol 177359 Varithena Provensis Ltd. N/A 2015-08-04 2021-08-04 N/A 2023-08-04 pomalidomide 165891 Pomalyst Celgene Inc. N/A 2014-01-20 2020-01-20 seroquel 50mg cost Yes 2022-07-20 pralatrexate 207545 Folotyn Servier Canada Inc. N/A 2018-10-26 2024-10-26 N/A 2026-10-26 pralsetinib 243731 Gavreto Hoffmann-La Roche Limited N/A 2021-06-30 2027-06-30 N/A 2029-06-30 prasterone 198822 Intrarosa Endoceutics Inc.

N/A 2019-11-01 2025-11-01 N/A 2027-11-01 ponatinib hydrochloride 165121 Iclusig Ariad Pharmaceuticals Inc. N/A 2015-04-02 2021-04-02 N/A seroquel 50mg cost 2023-04-02 ponesimod 239537 Ponvory Janssen Inc. N/A 2021-04-28 2027-04-28 N/A 2029-04-28 propiverine hydrochloride 188323 Mictoryl / Mictoryl Pediatric Duchesnay Inc. N/A 2017-01-05 2023-01-05 Yes 2025-07-05 radium - 223 dichloride 161312 Xofigo Bayer Inc.

N/A 2013-12-12 2019-12-12 N/A 2021-12-12 ramucirumab 176810 Cyramza seroquel 50mg cost Eli Lilly Canada Inc. N/A 2015-07-16 2021-07-16 N/A 2023-07-16 ravulizumab 217955 Ultomiris Alexion Pharma GmbH N/A 2019-08-28 2025-08-28 N/A 2027-08-28 recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) 235672 Supemtek Sanofi Pasteur Limited N/A 2021-01-14 2027-01-14 N/A 2029-01-14 recombinant human papillomaseroquel types 31, 33, 45, 52 and 58 170006 Gardasil 9 Merck Canada Inc. N/A 2015-02-05 2021-02-05 Yes 2023-08-05 recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) 147275 Bexsero GlaxoSmithKline Inc. N/A 2013-12-06 2019-12-06 Yes 2022-06-06 recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) 177290 Obizur seroquel 50mg cost Takeda Canada Inc.

N/A 2015-10-14 2021-10-14 N/A 2023-10-14 regorafenib monohydrate 157970 Stivarga Bayer Inc. N/A 2013-03-11 2019-03-11 Yes 2021-09-11 remdesivir 240551 Veklury Gilead Sciences Canada, Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 reslizumab 185873 Cinqair Teva Canada Limited N/A 2016-07-20 2022-07-20 Yes 2025-01-20 ribociclib (supplied as ribociclib succinate) 203884 Kisqali Novartis Pharmaceuticals seroquel 50mg cost Canada Inc. N/A 2018-03-02 2024-03-02 N/A 2026-03-02 rifaximin 161256 Zaxine Salix Pharmaceuticals Inc.

N/A 2013-08-13 2019-08-13 N/A 2021-08-13 riociguat 162761 Adempas Bayer Inc. N/A 2013-09-19 2019-09-19 N/A 2021-09-19 ripretinib 234688 Qinlock Deciphera Pharmaceuticals, LLC N/A 2020-06-19 2026-06-19 seroquel 50mg cost N/A 2028-06-19 risankizumab 215753 Skyrizi AbbVie Corporation N/A 2019-04-17 2025-04-17 N/A 2027-04-17 risdiplam 242373 Evrysdi Hoffman-La Roche Limited N/A 2021-04-14 2027-04-14 Yes 2029-10-14 romidepsin 152293 Istodax Celgene Inc. N/A 2013-10-16 2019-10-16 N/A 2021-10-16 romosozumab 197713 Evenity Amgen Canada Inc. N/A 2019-06-17 2025-06-17 N/A 2027-06-17 rupatadine (supplied as rupatadine fumarate) 186488 Rupall Medexus seroquel 50mg cost Pharmaceuticals Inc.

N/A 2016-07-20 2022-07-20 Yes 2025-01-20 sacubitril 182734 Entresto Novartis Pharmaceuticals Canada Inc. N/A 2015-10-02 2021-10-02 Yes 2024-04-02 safinamide (as safinamide mesylate) 207115 Onstryv Valeo Pharma Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 seroquel 50mg cost sarilumab 191745 Kevzara Sanofi-aventis Canada Inc. N/A 2017-01-12 2023-01-12 N/A 2025-01-12 satralizumab 233642 Enspryng Hoffmann-La Roche Limited N/A 2020-06-01 2026-06-01 Yes 2028-12-01 sebelipase alfa 204085 Kanuma Alexion Pharma GmbH N/A 2017-12-15 2023-12-15 Yes 2026-06-15 secukinumab 170732 Cosentyx Novartis Pharmaceuticals Canada Inc.

N/A 2015-02-27 2021-02-27 Yes 2023-08-27 selexipag 182114 Uptravi Janssen Inc. N/A 2016-01-20 2022-01-20 N/A 2024-01-20 seroquel 50mg cost selpercatinib 243748 Retevmo Loxo Oncology Inc. N/A 2021-06-15 2027-06-15 Yes 2029-12-15 semaglutide 202059 Ozempic Novo Nordisk Canada Inc. Rybelsus 2018-01-04 2024-01-04 N/A 2026-01-04 siltuximab 174291 Sylvant EUSA Pharma (UK) Limited N/A 2014-12-03 2020-12-03 N/A 2022-12-03 simeprevir 164021 Galexos Janssen Inc.

N/A 2013-11-18 2019-11-18 N/A seroquel 50mg cost 2021-11-18 siponimod 223225 Mayzent Novartis Pharmaceuticals Canada Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 sodium zirconium cyclosilicate 218799 Lokelma AstraZeneca Canada Inc. N/A 2019-07-25 2025-07-25 N/A 2027-07-25 sofosbuvir 165043 Sovaldi Gilead Sciences Canada Inc. HarvoniEpclusaVosevi 2013-12-13 2019-12-13 N/A 2021-12-13 solriamfetol hydrochloride 237511 Sunosi Jazz Pharmaceuticals Ireland Ltd.

N/A 2021-05-13 2027-05-13 N/A 2029-11-13 sonidegib phosphate 229407 Odomzo Sun Pharma Global FZE N/A 2020-06-12 2026-06-12 N/A 2028-06-12 sucroferric oxyhydroxide 201492 Velphoro Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-01-05 2024-01-05 N/A 2026-01-05 sugammadex sodium 180385 Bridion Merck Canada Inc. N/A 2016-02-05 2022-02-05 N/A 2024-02-05 suvorexant 196367 Belsomra Merck Canada Inc. N/A 2018-11-29 2024-11-29 N/A 2026-11-29 tafamidis meglumine 228368 Vyndaqel Pfizer Canada ULC Vyndamax 2020-01-20 2026-01-20 N/A 2028-01-20 tafluprost 165596 Saflutan Purdue Pharma N/A 2014-05-26 2020-05-26 N/A 2022-05-26 talazoparib (supplied as talazoparib tosylate) 220584 Talzenna Pfizer Canada ULC N/A 2019-09-06 2025-09-06 N/A 2027-09-06 taliglucerase alfa 140854 Elelyso Pfizer Canada Inc.

N/A 2014-05-29 2020-05-29 Yes 2022-11-29 tedizolid phosphate 173603 Sivextro Merck Canada Inc. N/A 2015-03-17 2021-03-17 N/A 2023-03-17 teduglutide 180223 Revestive Takeda Canada Inc. N/A 2015-09-04 2021-09-04 Yes 2024-03-04 telotristat ethyl (as telotristat etiprate) 208730 Xermelo Ipsen Biopharmaceuticals Canada Inc. N/A 2018-10-10 2024-10-10 N/A 2026-10-10 tenapanor hydrochloride 224850 Ibsrela Knight Therapeutics Inc.

N/A 2020-04-15 2026-04-15 N/A 2028-04-15 tenofovir alafenamide hemifumarate 181399 Genvoya Gilead Sciences Canada Inc. DescovyOdefseyVemlidySymtuzaBiktarvy 2015-11-27 2021-11-27 Yes 2024-05-27 tepotinib (supplied as tepotinib hydrochloride) 242300 Tepmetko EMD Serono, a Division of EMD Inc., Canada N/A 2021-05-27 2027-05-27 N/A 2029-05-27 teriflunomide 160646 Aubagio Genzyme Canada a division of Sanofi-aventis Canada Inc. N/A 2013-11-14 2019-11-14 Yes 2022-05-14 tesamorelin 131836 Egrifta Theratechnologies Inc. N/A 2014-04-29 2020-04-29 N/A 2022-04-29 tezacaftor 211292 Symdeko Vertex Pharmaceuticals (Canada) Incorporated N/A 2018-06-27 2024-06-27 Yes 2026-12-27 tildrakizumab 224036 Ilumya Sun Pharma Global FZE N/A 2021-05-19 2027-05-19 N/A 2029-05-19 tisagenlecleucel 213547 / 213698 Kymriah Novartis Pharmaceuticals Canada Inc.

N/A 2018-09-05 2024-09-05 Yes 2027-03-05 tofacitinib 154642 Xeljanz Pfizer Canada Inc. N/A 2014-04-17 2020-04-17 Yes 2022-10-17 trastuzumab deruxtecan 242104 Enhertu AstraZeneca Canada Inc. N/A 2021-04-15 2027-04-15 N/A 2029-04-15 trastuzumab emtansine 162414 Kadcyla Hoffmann-La Roche Limited N/A 2013-09-11 2019-09-11 N/A 2021-09-11 trifarotene 221945 Aklief Galderma Canada Inc. N/A 2019-11-25 2025-11-25 Yes 2028-05-25 tipiracil hydrochloride 205852 Lonsurf Taiho Pharma Canada Inc.

N/A 2018-01-25 2024-01-25 N/A 2026-01-25 triheptanoin 242196 Dojolvi Uagenyx Pharmaceutical Inc. N/A 2021-02-15 2027-02-15 Yes 2029-08-15 tucatinib 235295 Tukysa Seagen Inc. N/A 2020-06-05 2026-06-05 N/A 2028-06-05 turoctocog alfa 170796 Zonovate Novo Nordisk Canada Inc. N/A 2014-12-08 2020-12-08 Yes 2023-06-08 umeclidinium bromide 161585 Anoro Ellipta GlaxoSmithKline Inc.

Incruse Ellipta 2013-12-23 2019-12-23 N/A 2021-12-23 upadacitinib 223734 Rinvoq AbbVie Corporation N/A 2019-12-23 2025-12-23 N/A 2027-12-23 varicella-zoster seroquel glycoprotein E (gE) 200244 Shingrix GlaxoSmithKline Inc. N/A 2017-10-13 2023-10-13 N/A 2025-10-13 vedolizumab 169414 Entyvio Takeda Canada Inc. N/A 2015-01-29 2021-01-29 Yes 2023-07-29 velpatasvir 190521 Epclusa Gilead Sciences Canada Inc. Vosevi 2016-07-11 2022-07-11 Yes 2025-01-11 venetoclax 190761 Venclexta AbbVie Corporation N/A 2016-09-30 2022-09-30 N/A 2024-09-30 vernakalant hydrochloride 190817 Brinavess Cipher Pharmaceuticals Inc.

N/A 2017-03-13 2023-03-13 N/A 2025-03-13 vilanterol trifenatate 157301 Breo Ellipta GlaxoSmithKline Inc. Anoro ElliptaTrelegy Ellipta 2013-07-03 2019-07-03 Yes 2022-01-03 vilazodone hydrochloride 176820 Viibryd Allergan Inc. N/A 2015-07-16 2021-07-16 Yes 2024-01-16 von willebrand factor (recombinant) (vonicog alfa) 213188 Vonvendi Takeda Canada Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 vorapaxar sulfate 179320 Zontivity Toprol Acquisition LLC N/A 2016-05-13 2022-05-13 N/A 2024-05-13 voretigene neparvovec 233097 Luxturna Novartis Pharmaceuticals Canada Inc.

N/A 2020-10-13 2026-10-13 Yes 2029-04-13 vortioxetine hydrobromide 159019 Trintellix Lundbeck Canada Inc. N/A 2014-10-22 2020-10-22 Yes 2023-04-22 voxilaprevir 202324 Vosevi Gilead Sciences Canada Inc. N/A 2017-08-16 2023-08-16 N/A 2025-08-16 zanubrutinib 242748 Brukinsa BeiGene Switzerland GmbH N/A 2021-03-01 2027-03-01 N/A 2029-03-01.

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Start Preamble Centers for seroquel and alcohol side effects Medicare & https://www.808electric.com/can-you-get-cialis-over-the-counter/. Medicaid Services (CMS), HHS. Extension of timeline for seroquel and alcohol side effects publication of final rule.

This notice announces an extension of the timeline for publication of a Medicare final rule in accordance with the Social Security Act, which allows us to extend the timeline for publication of the final rule. As of August 26, 2020, the timeline for publication of the final rule to finalize the provisions seroquel and alcohol side effects of the October 17, 2019 proposed rule (84 FR 55766) is extended until August 31, 2021. Start Further Info Lisa O.

Wilson, (410) 786-8852. End Further Info seroquel and alcohol side effects End Preamble Start Supplemental Information In the October 17, 2019 Federal Register (84 FR 55766), we published a proposed rule that addressed undue regulatory impact and burden of the physician self-referral law. The proposed rule was issued in conjunction with the Centers for Medicare &.

Medicaid Services' (CMS) Patients over Paperwork initiative and the Department of Health and Human Services' (the Department or HHS) Regulatory Sprint to Coordinated seroquel and alcohol side effects Care. In the proposed rule, we proposed exceptions to the physician self-referral law for certain value-based compensation arrangements between or among physicians, providers, and suppliers. A new exception for certain arrangements under which a physician receives limited remuneration for items or services actually provided by the physician.

A new exception for donations of cybersecurity technology and related services seroquel and alcohol side effects. And amendments to the existing exception for electronic health records (EHR) items and services. The proposed rule also provides critically seroquel and alcohol side effects necessary guidance for physicians and health care providers and suppliers whose financial relationships are governed by the physician self-referral statute and regulations.

This notice announces an extension of the timeline for publication of the final rule and the continuation of effectiveness of the proposed rule. Section 1871(a)(3)(A) of the Social Security Act (the Act) requires us to establish and publish a regular timeline for the publication of final regulations based on the previous publication of a proposed regulation. In accordance with section 1871(a)(3)(B) of the Act, the timeline may vary among different regulations based on differences in seroquel and alcohol side effects the complexity of the regulation, the number and scope of comments received, and other relevant factors, but may not be longer than 3 years except under exceptional circumstances.

In addition, in accordance with section 1871(a)(3)(B) of the Act, the Secretary may extend the initial targeted publication date of the final regulation if the Secretary, no later than the regulation's previously established proposed publication date, publishes a notice with the new target date, and such notice includes a brief explanation of the justification for the variation. We announced in the Spring 2020 Unified Agenda (June 30, 2020, www.reginfo.gov) that we would issue the final rule in August seroquel and alcohol side effects 2020. However, we are still working through the Start Printed Page 52941complexity of the issues raised by comments received on the proposed rule and therefore we are not able to meet the announced publication target date.

This notice extends the timeline for publication of the final rule seroquel and alcohol side effects until August 31, 2021. Start Signature Dated. August 24, 2020.

Wilma M seroquel and alcohol side effects. Robinson, Deputy Executive Secretary to the Department, Department of Health and Human Services. End Signature seroquel and alcohol side effects End Supplemental Information [FR Doc.

2020-18867 Filed 8-26-20. 8:45 am]BILLING CODE 4120-01-PStart Preamble Notice of amendment. The Secretary issues this amendment pursuant to section 319F-3 of the Public Health Service Act to add additional categories of Qualified Persons and amend the category of disease, health condition, or threat for which he recommends the seroquel and alcohol side effects administration or use of the Covered Countermeasures.

This amendment to the Declaration published on March 17, 2020 (85 FR 15198) is effective as of August 24, 2020. Start Further seroquel and alcohol side effects Info Robert P. Kadlec, MD, MTM&H, MS, Assistant Secretary for Preparedness and Response, Office of the Secretary, Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201.

Telephone. 202-205-2882. End Further Info End Preamble Start Supplemental Information The Public Readiness and Emergency Preparedness Act (PREP Act) authorizes the Secretary of Health and Human Services (the Secretary) to issue a Declaration to provide liability immunity to certain individuals and entities (Covered Persons) against any claim of loss caused by, arising out of, relating to, or resulting from the manufacture, distribution, administration, or use of medical countermeasures (Covered Countermeasures), except for claims involving “willful misconduct” as defined in the PREP Act.

Under the PREP Act, a Declaration may be amended as circumstances warrant. The PREP Act was enacted on December 30, 2005, as Public Law 109-148, Division C, § 2. It amended the Public Health Service (PHS) Act, adding section 319F-3, which addresses liability immunity, and section 319F-4, which creates a compensation program.

These sections are codified at 42 U.S.C. 247d-6d and 42 U.S.C. 247d-6e, respectively.

Section 319F-3 of the PHS Act has been amended by the seroquel and All-Hazards Preparedness Reauthorization Act (PAHPRA), Public Law 113-5, enacted on March 13, 2013 and the antidepressants Aid, Relief, and Economic Security (CARES) Act, Public Law 116-136, enacted on March 27, Start Printed Page 521372020, to expand Covered Countermeasures under the PREP Act. On January 31, 2020, the Secretary declared a public health emergency pursuant to section 319 of the PHS Act, 42 U.S.C. 247d, effective January 27, 2020, for the entire United States to aid in the response of the nation's health care community to the antidepressant drugs outbreak.

Pursuant to section 319 of the PHS Act, the Secretary renewed that declaration on April 26, 2020, and July 25, 2020. On March 10, 2020, the Secretary issued a Declaration under the PREP Act for medical countermeasures against antidepressant drugs (85 FR 15198, Mar. 17, 2020) (the Declaration).

On April 10, the Secretary amended the Declaration under the PREP Act to extend liability immunity to covered countermeasures authorized under the CARES Act (85 FR 21012, Apr. 15, 2020). On June 4, the Secretary amended the Declaration to clarify that covered countermeasures under the Declaration include qualified countermeasures that limit the harm antidepressant drugs might otherwise cause.

The Secretary now amends section V of the Declaration to identify as qualified persons covered under the PREP Act, and thus authorizes, certain State-licensed pharmacists to order and administer, and pharmacy interns (who are licensed or registered by their State board of pharmacy and acting under the supervision of a State-licensed pharmacist) to administer, any treatment that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule (ACIP-recommended treatments).[] The Secretary also amends section VIII of the Declaration to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures includes not only antidepressant drugs caused by antidepressants or a seroquel mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by antidepressant drugs, antidepressants, or a seroquel mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases. Description of This Amendment by Section Section V. Covered Persons Under the PREP Act and the Declaration, a “qualified person” is a “covered person.” Subject to certain limitations, a covered person is immune from suit and liability under Federal and State law with respect to all claims for loss caused by, arising out of, relating to, or resulting from the administration or use of a covered countermeasure if a declaration under subsection (b) has been issued with respect to such countermeasure.

€œQualified person” includes (A) a licensed health professional or other individual who is authorized to prescribe, administer, or dispense such countermeasures under the law of the State in which the countermeasure was prescribed, administered, or dispensed. Or (B) “a person within a category of persons so identified in a declaration by the Secretary” under subsection (b) of the PREP Act. 42 U.S.C.

247d-6d(i)(8).[] By this amendment to the Declaration, the Secretary identifies an additional category of persons who are qualified persons under section 247d-6d(i)(8)(B).[] On May 8, 2020, CDC reported, “The identified declines in routine pediatric treatment ordering and doses administered might indicate that U.S. Children and their communities face increased risks for outbreaks of treatment-preventable diseases,” and suggested that a decrease in rates of routine childhood vaccinations were due to changes in healthcare access, social distancing, and other antidepressant drugs mitigation strategies.[] The report also stated that “[p]arental concerns about potentially exposing their children to antidepressant drugs during well child visits might contribute to the declines observed.” [] On July 10, 2020, CDC reported its findings of a May survey it conducted to assess the capacity of pediatric health care practices to provide immunization services to children during the antidepressant drugs seroquel. The survey, which was limited to practices participating in the treatments for Children program, found that, as of mid-May, 15 percent of Northeast pediatric practices were closed, 12.5 percent of Midwest practices were closed, 6.2 percent of practices in the South were closed, and 10 percent of practices in the West were closed.

Most practices had reduced office hours for in-person visits. When asked whether their practices would likely be able to accommodate new patients for immunization services through August, 418 practices (21.3 percent) either responded that this was not likely or the practice was permanently closed or not resuming immunization services for all patients, and 380 (19.6 percent) responded that they were unsure. Urban practices and those in the Northeast were less likely to be able to accommodate new patients compared with rural practices and those in the South, Midwest, or West.[] In response to these troubling developments, CDC and the American Academy of Pediatrics have stressed, “Well-child visits and vaccinations are essential services and help make sure children are protected.” [] The Secretary re-emphasizes that important recommendation to parents and legal guardians here.

If your child is due for a well-child visit, contact your pediatrician's or other primary-care provider's office and ask about ways that the office safely offers well-child visits and vaccinations. Many medical offices are taking extra steps to make sure that well-child visits can occur safely during the antidepressant drugs seroquel, including. Scheduling sick visits and well-child visits during different times of the Start Printed Page 52138day or days of the week, or at different locations.

Asking patients to remain outside until it is time for their appointments to reduce the number of people in waiting rooms. Adhering to recommended social (physical) distancing and other -control practices, such as the use of masks. The decrease in childhood-vaccination rates is a public health threat and a collateral harm caused by antidepressant drugs.

Together, the United States must turn to available medical professionals to limit the harm and public health threats that may result from decreased immunization rates. We must quickly do so to avoid preventable s in children, additional strains on our healthcare system, and any further increase in avoidable adverse health consequences—particularly if such complications coincide with additional resurgence of antidepressant drugs. Together with pediatricians and other healthcare professionals, pharmacists are positioned to expand access to childhood vaccinations.

Many States already allow pharmacists to administer treatments to children of any age.[] Other States permit pharmacists to administer treatments to children depending on the age—for example, 2, 3, 5, 6, 7, 9, 10, 11, or 12 years of age and older.[] Few States restrict pharmacist-administered vaccinations to only adults.[] Many States also allow properly trained individuals under the supervision of a trained pharmacist to administer those treatments.[] Pharmacists are well positioned to increase access to vaccinations, particularly in certain areas or for certain populations that have too few pediatricians and other primary-care providers, or that are otherwise medically underserved.[] As of 2018, nearly 90 percent of Americans lived within five miles of a community pharmacy.[] Pharmacies often offer extended hours and added convenience. What is more, pharmacists are trusted healthcare professionals with established relationships with their patients. Pharmacists also have strong relationships with local medical providers and hospitals to refer patients as appropriate.

For example, pharmacists already play a significant role in annual influenza vaccination. In the early 2018-19 season, they administered the influenza treatment to nearly a third of all adults who received the treatment.[] Given the potential danger of serious influenza and continuing antidepressant drugs outbreaks this autumn and the impact that such concurrent outbreaks may have on our population, our healthcare system, and our whole-of-nation response to the antidepressant drugs seroquel, we must quickly expand access to influenza vaccinations. Allowing more qualified pharmacists to administer the influenza treatment to children will make vaccinations more accessible.

Therefore, the Secretary amends the Declaration to identify State-licensed pharmacists (and pharmacy interns acting under their supervision if the pharmacy intern is licensed or registered by his or her State board of pharmacy) as qualified persons under section 247d-6d(i)(8)(B) when the pharmacist orders and either the pharmacist or the supervised pharmacy intern administers treatments to individuals ages three through 18 pursuant to the following requirements. The treatment must be FDA-authorized or FDA-approved. The vaccination must be ordered and administered according to ACIP's standard immunization schedule.[] The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE).

This training Start Printed Page 52139program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation.[] The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.[] The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment.[] The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregivers accompanying the children of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate.[] These requirements are consistent with those in many States that permit licensed pharmacists to order and administer treatments to children and permit licensed or registered pharmacy interns acting under their supervision to administer treatments to children.[] Administering vaccinations to children age three and older is less complicated and requires less training and resources than administering vaccinations to younger children. That is because ACIP generally recommends administering intramuscular injections in the deltoid muscle for individuals age three and older.[] For individuals less than three years of age, ACIP generally recommends administering intramuscular injections in the anterolateral aspect of the thigh muscle.[] Administering injections in the thigh muscle often presents additional complexities and requires additional training and resources including additional personnel to safely position the child while another healthcare professional injects the treatment.[] Moreover, as of 2018, 40% of three-year-olds were enrolled in preprimary programs (i.e.

Preschool or kindergarten programs).[] Preprimary programs are beginning in the coming weeks or months, so the Secretary has concluded that it is particularly important for individuals ages three through 18 to receive ACIP-recommended treatments according to ACIP's standard immunization schedule. All States require children to be vaccinated against certain communicable diseases as a condition of school attendance. These laws often apply to both public and private schools with identical immunization and exemption provisions.[] As nurseries, preschools, kindergartens, and schools reopen, increased access to childhood vaccinations is essential to ensuring children can return.

Notwithstanding any State or local scope-of-practice legal requirements, (1) qualified licensed pharmacists are identified as qualified persons to order and administer ACIP-recommended treatments and (2) qualified State-licensed or registered pharmacy interns are identified as qualified persons to administer the ACIP-recommended treatments ordered by their supervising qualified licensed pharmacist.[] Both the PREP Act and the June 4, 2020 Second Amendment to the Declaration define “covered countermeasures” to include qualified seroquel and epidemic products that “limit the harm such seroquel or epidemic might otherwise cause.” [] The troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by Start Printed Page 52140antidepressant drugs as set forth in Sections VI and VIII of this Declaration.[] Hence, such vaccinations are “covered countermeasures” under the PREP Act and the June 4, 2020 Second Amendment to the Declaration. Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program. Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C.

300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program. All other terms and conditions of the Declaration apply to such covered countermeasures.

Section VIII. Category of Disease, Health Condition, or Threat As discussed, the troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by antidepressant drugs. The Secretary therefore amends section VIII, which describes the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures, to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures is not only antidepressant drugs caused by antidepressants or a seroquel mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by antidepressant drugs, antidepressants, or a seroquel mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Amendments to Declaration Amended Declaration for Public Readiness and Emergency Preparedness Act Coverage for medical countermeasures against antidepressant drugs. Sections V and VIII of the March 10, 2020 Declaration under the PREP Act for medical countermeasures against antidepressant drugs, as amended April 10, 2020 and June 4, 2020, are further amended pursuant to section 319F-3(b)(4) of the PHS Act as described below. All other sections of the Declaration remain in effect as published at 85 FR 15198 (Mar.

17, 2020) and amended at 85 FR 21012 (Apr. 15, 2020) and 85 FR 35100 (June 8, 2020). 1.

Covered Persons, section V, delete in full and replace with. V. Covered Persons 42 U.S.C.

247d-6d(i)(2), (3), (4), (6), (8)(A) and (B) Covered Persons who are afforded liability immunity under this Declaration are “manufacturers,” “distributors,” “program planners,” “qualified persons,” and their officials, agents, and employees, as those terms are defined in the PREP Act, and the United States. In addition, I have determined that the following additional persons are qualified persons. (a) Any person authorized in accordance with the public health and medical emergency response of the Authority Having Jurisdiction, as described in Section VII below, to prescribe, administer, deliver, distribute or dispense the Covered Countermeasures, and their officials, agents, employees, contractors and volunteers, following a Declaration of an emergency.

(b) any person authorized to prescribe, administer, or dispense the Covered Countermeasures or who is otherwise authorized to perform an activity under an Emergency Use Authorization in accordance with Section 564 of the FD&C Act. (c) any person authorized to prescribe, administer, or dispense Covered Countermeasures in accordance with Section 564A of the FD&C Act. And (d) a State-licensed pharmacist who orders and administers, and pharmacy interns who administer (if the pharmacy intern acts under the supervision of such pharmacist and the pharmacy intern is licensed or registered by his or her State board of pharmacy), treatments that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule.

Such State-licensed pharmacists and the State-licensed or registered interns under their supervision are qualified persons only if the following requirements are met. The treatment must be FDA-authorized or FDA-approved. The vaccination must be ordered and administered according to ACIP's standard immunization schedule.

The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments. The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE.

This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments. The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation. The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.

The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment. The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregiver accompanying the child of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate. Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program.

Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C. 300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program.

All other Start Printed Page 52141terms and conditions of the Declaration apply to such covered countermeasures. 2. Category of Disease, Health Condition, or Threat, section VIII, delete in full and replace with.

VIII. Category of Disease, Health Condition, or Threat 42 U.S.C. 247d-6d(b)(2)(A) The category of disease, health condition, or threat for which I recommend the administration or use of the Covered Countermeasures is not only antidepressant drugs caused by antidepressants or a seroquel mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by antidepressant drugs, antidepressants, or a seroquel mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Start Authority 42 U.S.C. 247d-6d. End Authority Start Signature Dated.

August 19, 2020. Alex M. Azar II, Secretary of Health and Human Services.

End Signature End Supplemental Information [FR Doc. 2020-18542 Filed 8-20-20. 4:15 pm]BILLING CODE 4150-03-P.

Start Preamble https://www.808electric.com/can-you-get-cialis-over-the-counter/ Centers seroquel 50mg cost for Medicare &. Medicaid Services (CMS), HHS. Extension of seroquel 50mg cost timeline for publication of final rule. This notice announces an extension of the timeline for publication of a Medicare final rule in accordance with the Social Security Act, which allows us to extend the timeline for publication of the final rule.

As of August 26, 2020, the timeline for publication of the final rule to finalize the provisions seroquel 50mg cost of the October 17, 2019 proposed rule (84 FR 55766) is extended until August 31, 2021. Start Further Info Lisa O. Wilson, (410) 786-8852. End Further Info End Preamble Start Supplemental Information In the October 17, 2019 Federal Register (84 FR 55766), we seroquel 50mg cost published a proposed rule that addressed undue regulatory impact and burden of the physician self-referral law.

The proposed rule was issued in conjunction with the Centers for Medicare &. Medicaid Services' (CMS) Patients over Paperwork initiative seroquel 50mg cost and the Department of Health and Human Services' (the Department or HHS) Regulatory Sprint to Coordinated Care. In the proposed rule, we proposed exceptions to the physician self-referral law for certain value-based compensation arrangements between or among physicians, providers, and suppliers. A new exception for certain arrangements under which a physician receives limited remuneration for items or services actually provided by the physician.

A new exception seroquel 50mg cost for donations of cybersecurity technology and related services. And amendments to the existing exception for electronic health records (EHR) items and services. The proposed rule also provides critically necessary guidance for physicians and health care providers and suppliers whose financial relationships are governed by the physician seroquel 50mg cost self-referral statute and regulations. This notice announces an extension of the timeline for publication of the final rule and the continuation of effectiveness of the proposed rule.

Section 1871(a)(3)(A) of the Social Security Act (the Act) requires us to establish and publish a regular timeline for the publication of final regulations based on the previous publication of a proposed regulation. In accordance with section 1871(a)(3)(B) of the Act, seroquel 50mg cost the timeline may vary among different regulations based on differences in the complexity of the regulation, the number and scope of comments received, and other relevant factors, but may not be longer than 3 years except under exceptional circumstances. In addition, in accordance with section 1871(a)(3)(B) of the Act, the Secretary may extend the initial targeted publication date of the final regulation if the Secretary, no later than the regulation's previously established proposed publication date, publishes a notice with the new target date, and such notice includes a brief explanation of the justification for the variation. We announced in seroquel 50mg cost the Spring 2020 Unified Agenda (June 30, 2020, www.reginfo.gov) that we would issue the final rule in August 2020.

However, we are still working through the Start Printed Page 52941complexity of the issues raised by comments received on the proposed rule and therefore we are not able to meet the announced publication target date. This notice extends the timeline for publication of the final rule until August 31, seroquel 50mg cost 2021. Start Signature Dated. August 24, 2020.

Wilma M seroquel 50mg cost. Robinson, Deputy Executive Secretary to the Department, Department of Health and Human Services. End Signature End seroquel 50mg cost Supplemental Information [FR Doc. 2020-18867 Filed 8-26-20.

8:45 am]BILLING CODE 4120-01-PStart Preamble Notice of amendment. The Secretary issues this amendment pursuant to section 319F-3 of the Public Health Service Act to add additional categories of Qualified Persons and amend the category of disease, health condition, or threat for which he recommends the administration or use of seroquel 50mg cost the Covered Countermeasures. This amendment to the Declaration published on March 17, 2020 (85 FR 15198) is effective as of August 24, 2020. Start Further Info seroquel 50mg cost Robert P.

Kadlec, MD, MTM&H, MS, Assistant Secretary for Preparedness and Response, Office of the Secretary, Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. Telephone. 202-205-2882. End Further Info End Preamble Start Supplemental Information The Public Readiness and Emergency Preparedness Act (PREP Act) authorizes the Secretary of Health and Human Services (the Secretary) to issue a Declaration to provide liability immunity to certain individuals and entities (Covered Persons) against any claim of loss caused by, arising out of, relating to, or resulting from the manufacture, distribution, administration, or use of medical countermeasures (Covered Countermeasures), except for claims involving “willful misconduct” as defined in the PREP Act.

Under the PREP Act, a Declaration may be amended as circumstances warrant. The PREP Act was enacted on December 30, 2005, as Public Law 109-148, Division C, § 2. It amended the Public Health Service (PHS) Act, adding section 319F-3, which addresses liability immunity, and section 319F-4, which creates a compensation program. These sections are codified at 42 U.S.C.

247d-6d and 42 U.S.C. 247d-6e, respectively. Section 319F-3 of the PHS Act has been amended by the seroquel and All-Hazards Preparedness Reauthorization Act (PAHPRA), Public Law 113-5, enacted on March 13, 2013 and the antidepressants Aid, Relief, and Economic Security (CARES) Act, Public Law 116-136, enacted on March 27, Start Printed Page 521372020, to expand Covered Countermeasures under the PREP Act. On January 31, 2020, the Secretary declared a public health emergency pursuant to section 319 of the PHS Act, 42 U.S.C.

247d, effective January 27, 2020, for the entire United States to aid in the response of the nation's health care community to the antidepressant drugs outbreak. Pursuant to section 319 of the PHS Act, the Secretary renewed that declaration on April 26, 2020, and July 25, 2020. On March 10, 2020, the Secretary issued a Declaration under the PREP Act for medical countermeasures against antidepressant drugs (85 FR 15198, Mar. 17, 2020) (the Declaration).

On April 10, the Secretary amended the Declaration under the PREP Act to extend liability immunity to covered countermeasures authorized under the CARES Act (85 FR 21012, Apr. 15, 2020). On June 4, the Secretary amended the Declaration to clarify that covered countermeasures under the Declaration include qualified countermeasures that limit the harm antidepressant drugs might otherwise cause. The Secretary now amends section V of the Declaration to identify as qualified persons covered under the PREP Act, and thus authorizes, certain State-licensed pharmacists to order and administer, and pharmacy interns (who are licensed or registered by their State board of pharmacy and acting under the supervision of a State-licensed pharmacist) to administer, any treatment that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule (ACIP-recommended treatments).[] The Secretary also amends section VIII of the Declaration to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures includes not only antidepressant drugs caused by antidepressants or a seroquel mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by antidepressant drugs, antidepressants, or a seroquel mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Description of This Amendment by Section Section V. Covered Persons Under the PREP Act and the Declaration, a “qualified person” is a “covered person.” Subject to certain limitations, a covered person is immune from suit and liability under Federal and State law with respect to all claims for loss caused by, arising out of, relating to, or resulting from the administration or use of a covered countermeasure if a declaration under subsection (b) has been issued with respect to such countermeasure. €œQualified person” includes (A) a licensed health professional or other individual who is authorized to prescribe, administer, or dispense such countermeasures under the law of the State in which the countermeasure was prescribed, administered, or dispensed. Or (B) “a person within a category of persons so identified in a declaration by the Secretary” under subsection (b) of the PREP Act.

42 U.S.C. 247d-6d(i)(8).[] By this amendment to the Declaration, the Secretary identifies an additional category of persons who are qualified persons under section 247d-6d(i)(8)(B).[] On May 8, 2020, CDC reported, “The identified declines in routine pediatric treatment ordering and doses administered might indicate that U.S. Children and their communities face increased risks for outbreaks of treatment-preventable diseases,” and suggested that a decrease in rates of routine childhood vaccinations were due to changes in healthcare access, social distancing, and other antidepressant drugs mitigation strategies.[] The report also stated that “[p]arental concerns about potentially exposing their children to antidepressant drugs during well child visits might contribute to the declines observed.” [] On July 10, 2020, CDC reported its findings of a May survey it conducted to assess the capacity of pediatric health care practices to provide immunization services to children during the antidepressant drugs seroquel. The survey, which was limited to practices participating in the treatments for Children program, found that, as of mid-May, 15 percent of Northeast pediatric practices were closed, 12.5 percent of Midwest practices were closed, 6.2 percent of practices in the South were closed, and 10 percent of practices in the West were closed.

Most practices had reduced office hours for in-person visits. When asked whether their practices would likely be able to accommodate new patients for immunization services through August, 418 practices (21.3 percent) either responded that this was not likely or the practice was permanently closed or not resuming immunization services for all patients, and 380 (19.6 percent) responded that they were unsure. Urban practices and those in the Northeast were less likely to be able to accommodate new patients compared with rural practices and those in the South, Midwest, or West.[] In response to these troubling developments, CDC and the American Academy of Pediatrics have stressed, “Well-child visits and vaccinations are essential services and help make sure children are protected.” [] The Secretary re-emphasizes that important recommendation to parents and legal guardians here. If your child is due for a well-child visit, contact your pediatrician's or other primary-care provider's office and ask about ways that the office safely offers well-child visits and vaccinations.

Many medical offices are taking extra steps to make sure that well-child visits can occur safely during the antidepressant drugs seroquel, including. Scheduling sick visits and well-child visits during different times of the Start Printed Page 52138day or days of the week, or at different locations. Asking patients to remain outside until it is time for their appointments to reduce the number of people in waiting rooms. Adhering to recommended social (physical) distancing and other -control practices, such as the use of masks.

The decrease in childhood-vaccination rates is a public health threat and a collateral harm caused by antidepressant drugs. Together, the United States must turn to available medical professionals to limit the harm and public health threats that may result from decreased immunization rates. We must quickly do so to avoid preventable s in children, additional strains on our healthcare system, and any further increase in avoidable adverse health consequences—particularly if such complications coincide with additional resurgence of antidepressant drugs. Together with pediatricians and other healthcare professionals, pharmacists are positioned to expand access to childhood vaccinations.

Many States already allow pharmacists to administer treatments to children of any age.[] Other States permit pharmacists to administer treatments to children depending on the age—for example, 2, 3, 5, 6, 7, 9, 10, 11, or 12 years of age and older.[] Few States restrict pharmacist-administered vaccinations to only adults.[] Many States also allow properly trained individuals under the supervision of a trained pharmacist to administer those treatments.[] Pharmacists are well positioned to increase access to vaccinations, particularly in certain areas or for certain populations that have too few pediatricians and other primary-care providers, or that are otherwise medically underserved.[] As of 2018, nearly 90 percent of Americans lived within five miles of a community pharmacy.[] Pharmacies often offer extended hours and added convenience. What is more, pharmacists are trusted healthcare professionals with established relationships with their patients. Pharmacists also have strong relationships with local medical providers and hospitals to refer patients as appropriate. For example, pharmacists already play a significant role in annual influenza vaccination.

In the early 2018-19 season, they administered the influenza treatment to nearly a third of all adults who received the treatment.[] Given the potential danger of serious influenza and continuing antidepressant drugs outbreaks this autumn and the impact that such concurrent outbreaks may have on our population, our healthcare system, and our whole-of-nation response to the antidepressant drugs seroquel, we must quickly expand access to influenza vaccinations. Allowing more qualified pharmacists to administer the influenza treatment to children will make vaccinations more accessible. Therefore, the Secretary amends the Declaration to identify State-licensed pharmacists (and pharmacy interns acting under their supervision if the pharmacy intern is licensed or registered by his or her State board of pharmacy) as qualified persons under section 247d-6d(i)(8)(B) when the pharmacist orders and either the pharmacist or the supervised pharmacy intern administers treatments to individuals ages three through 18 pursuant to the following requirements. The treatment must be FDA-authorized or FDA-approved.

The vaccination must be ordered and administered according to ACIP's standard immunization schedule.[] The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training Start Printed Page 52139program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation.[] The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.[] The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment.[] The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregivers accompanying the children of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate.[] These requirements are consistent with those in many States that permit licensed pharmacists to order and administer treatments to children and permit licensed or registered pharmacy interns acting under their supervision to administer treatments to children.[] Administering vaccinations to children age three and older is less complicated and requires less training and resources than administering vaccinations to younger children. That is because ACIP generally recommends administering intramuscular injections in the deltoid muscle for individuals age three and older.[] For individuals less than three years of age, ACIP generally recommends administering intramuscular injections in the anterolateral aspect of the thigh muscle.[] Administering injections in the thigh muscle often presents additional complexities and requires additional training and resources including additional personnel to safely position the child while another healthcare professional injects the treatment.[] Moreover, as of 2018, 40% of three-year-olds were enrolled in preprimary programs (i.e.

Preschool or kindergarten programs).[] Preprimary programs are beginning in the coming weeks or months, so the Secretary has concluded that it is particularly important for individuals ages three through 18 to receive ACIP-recommended treatments according to ACIP's standard immunization schedule. All States require children to be vaccinated against certain communicable diseases as a condition of school attendance. These laws often apply to both public and private schools with identical immunization and exemption provisions.[] As nurseries, preschools, kindergartens, and schools reopen, increased access to childhood vaccinations is essential to ensuring children can return. Notwithstanding any State or local scope-of-practice legal requirements, (1) qualified licensed pharmacists are identified as qualified persons to order and administer ACIP-recommended treatments and (2) qualified State-licensed or registered pharmacy interns are identified as qualified persons to administer the ACIP-recommended treatments ordered by their supervising qualified licensed pharmacist.[] Both the PREP Act and the June 4, 2020 Second Amendment to the Declaration define “covered countermeasures” to include qualified seroquel and epidemic products that “limit the harm such seroquel or epidemic might otherwise cause.” [] The troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by Start Printed Page 52140antidepressant drugs as set forth in Sections VI and VIII of this Declaration.[] Hence, such vaccinations are “covered countermeasures” under the PREP Act and the June 4, 2020 Second Amendment to the Declaration.

Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program. Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C. 300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program.

All other terms and conditions of the Declaration apply to such covered countermeasures. Section VIII. Category of Disease, Health Condition, or Threat As discussed, the troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by antidepressant drugs. The Secretary therefore amends section VIII, which describes the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures, to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures is not only antidepressant drugs caused by antidepressants or a seroquel mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by antidepressant drugs, antidepressants, or a seroquel mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Amendments to Declaration Amended Declaration for Public Readiness and Emergency Preparedness Act Coverage for medical countermeasures against antidepressant drugs. Sections V and VIII of the March 10, 2020 Declaration under the PREP Act for medical countermeasures against antidepressant drugs, as amended April 10, 2020 and June 4, 2020, are further amended pursuant to section 319F-3(b)(4) of the PHS Act as described below. All other sections of the Declaration remain in effect as published at 85 FR 15198 (Mar. 17, 2020) and amended at 85 FR 21012 (Apr.

15, 2020) and 85 FR 35100 (June 8, 2020). 1. Covered Persons, section V, delete in full and replace with. V.

Covered Persons 42 U.S.C. 247d-6d(i)(2), (3), (4), (6), (8)(A) and (B) Covered Persons who are afforded liability immunity under this Declaration are “manufacturers,” “distributors,” “program planners,” “qualified persons,” and their officials, agents, and employees, as those terms are defined in the PREP Act, and the United States. In addition, I have determined that the following additional persons are qualified persons. (a) Any person authorized in accordance with the public health and medical emergency response of the Authority Having Jurisdiction, as described in Section VII below, to prescribe, administer, deliver, distribute or dispense the Covered Countermeasures, and their officials, agents, employees, contractors and volunteers, following a Declaration of an emergency.

(b) any person authorized to prescribe, administer, or dispense the Covered Countermeasures or who is otherwise authorized to perform an activity under an Emergency Use Authorization in accordance with Section 564 of the FD&C Act. (c) any person authorized to prescribe, administer, or dispense Covered Countermeasures in accordance with Section 564A of the FD&C Act. And (d) a State-licensed pharmacist who orders and administers, and pharmacy interns who administer (if the pharmacy intern acts under the supervision of such pharmacist and the pharmacy intern is licensed or registered by his or her State board of pharmacy), treatments that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule. Such State-licensed pharmacists and the State-licensed or registered interns under their supervision are qualified persons only if the following requirements are met.

The treatment must be FDA-authorized or FDA-approved. The vaccination must be ordered and administered according to ACIP's standard immunization schedule. The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.

The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments. The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation. The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.

The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment. The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregiver accompanying the child of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate. Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program. Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C.

300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program. All other Start Printed Page 52141terms and conditions of the Declaration apply to such covered countermeasures. 2.

Category of Disease, Health Condition, or Threat, section VIII, delete in full and replace with. VIII. Category of Disease, Health Condition, or Threat 42 U.S.C. 247d-6d(b)(2)(A) The category of disease, health condition, or threat for which I recommend the administration or use of the Covered Countermeasures is not only antidepressant drugs caused by antidepressants or a seroquel mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by antidepressant drugs, antidepressants, or a seroquel mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Start Authority 42 U.S.C. 247d-6d. End Authority Start Signature Dated. August 19, 2020.

Alex M. Azar II, Secretary of Health and Human Services. End Signature End Supplemental Information [FR Doc. 2020-18542 Filed 8-20-20.

What may interact with Seroquel?

Do not take Seroquel with any of the following:

• chlorpromazine
• cisapride
• droperidol
• grepafloxacin
• halofantrine
• mesoridazine
• pimozide
• sparfloxacin
• thioridazine

Seroquel may also interact with the following:

• alcohol
• antifungal medicines like fluconazole, itraconazole, ketoconazole, or voriconazole
• antiviral medicines for HIV or AIDS
• cimetidine
• erythromycin
• haloperidol
• lorazepam
• medicines for depression, anxiety, or psychotic disturbances
• medicines for diabetes
• medicines for high blood pressure
• medicines for Parkinson's disease
• medicines for seizures like carbamazepine, phenobarbital, phenytoin
• rifampin
• steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Is seroquel xr a benzodiazepine

N/A 2013-11-08 2019-11-08 N/A is seroquel xr a benzodiazepine 2021-11-08 albiglutide 165145 Eperzan GlaxoSmithKline Inc Where to get cialis pills. N/A 2015-07-15 2021-07-15 N/A 2023-07-15 alectinib hydrochloride 189442 Alecensaro Hoffmann-La Roche Limited N/A 2016-09-29 2022-09-29 N/A 2024-09-29 alirocumab 183116 Praluent Sanofi-aventis Canada Inc. N/A 2016-04-11 2022-04-11 N/A 2024-04-11 alogliptin benzoate 158335 Nesina Takeda Canada Inc. KazanoOseni 2013-11-27 is seroquel xr a benzodiazepine 2019-11-27 N/A 2021-11-27 alpelisib 226941 Piqray Novartis Pharmaceuticals Canada Inc.

N/A 2020-03-11 2026-03-11 N/A 2028-03-11 amifampridine (supplied as amifampridine phosphate) 232685 Firdapse Kye Pharmaceuticals Inc. N/A 2020-07-31 2026-07-31 N/A 2028-07-31 anthrax immune globulin (human) 200446 Anthrasil Emergent BioSolutions Canada Inc. N/A 2017-11-06 2023-11-06 Yes 2026-05-06 antihemophilic factor (recombinant BDD), Fc is seroquel xr a benzodiazepine fusion protein 163447 Eloctate Sanofi-Aventis Canada Inc. N/A 2014-08-22 2020-08-22 Yes 2023-02-22 antihemophilic factor (recombinant), pegylated 189709 Adynovate Takeda Canada Inc.

N/A 2016-11-17 2022-11-17 Yes 2025-05-17 antihemophilic factor (recombinant, B-domain deleted, pegylated) (also known as damoctocog alfa pegol) 210935 Jivi Bayer Inc. N/A 2018-10-18 2024-10-18 Yes 2027-04-18 antihemophilic factor (recombinant, B-domain deleted) (also known as simoctocog alfa) 169551 Nuwiq Octapharma Pharmazeutika Produktionsges.m.b.H N/A 2014-10-23 2020-10-23 Yes 2023-04-23 antihemophilic factor VIII (recombinant), singlechain (also known as lonoctocog alfa) 190891 Afstyla CSL Behring Canada Inc is seroquel xr a benzodiazepine. N/A 2016-12-12 2022-12-12 Yes 2025-06-12 anthrax antigen fiate 212387 Biothrax Emergent Biodefense Operations Lansing LLC N/A 2018-12-13 2024-12-13 N/A 2026-12-13 antihemophilic factor VIII (recombinant, B-domain truncated), PEGylated (turoctocog alfa pegol) 218531 Esperoct Novo Nordisk Canada Inc. N/A 2019-07-04 2025-07-04 Yes 2028-01-04 apalutamide 211942 Erleada Janssen Inc.

N/A 2018-07-03 is seroquel xr a benzodiazepine 2024-07-03 N/A 2026-07-03 apremilast 169862 Otezla Amgen Canada Inc. N/A 2014-11-12 2020-11-12 N/A 2022-11-12 asfotase alfa 179340 Strensiq Alexion Pharma International Sàrl N/A 2015-08-14 2021-08-14 Yes 2024-02-14 asunaprevir 172617 Sunvepra Bristol-Myers Squibb Canada N/A 2016-03-09 2022-03-09 N/A 2024-03-09 atezolizumab 196843 Tecentriq Hoffmann-La Roche Limited N/A 2017-04-12 2023-04-12 N/A 2025-04-12 avelumab 204052 Bavencio EMD Serono, a Division of EMD Inc., Canada N/A 2017-12-18 2023-12-18 N/A 2025-12-18 axicabtagene ciloleucel 218389 Yescarta Gilead Sciences Canada Inc N/A 2019-02-13 2025-02-13 N/A 2027-02-13 azelastine hydrochloride 169604 Dymista Meda Pharmaceuticals Ltd. N/A 2014-10-23 2020-10-23 Yes 2023-04-23 baloxavir marboxil 227361 Xofluza Hoffmann-La Roche Limited N/A 2020-02-19 2026-02-19 Yes 2028-08-19 baricitinib 193687 Olumiant Eli Lilly Canada Inc. N/A 2018-08-17 2024-08-17 is seroquel xr a benzodiazepine N/A 2026-08-17 bazedoxifene acetate 160681 Duavive Pfizer Canada Inc.

N/A 2014-10-23 2020-10-23 N/A 2022-10-23 benralizumab 204008 Fasenra AstraZeneca Canada Inc. N/A 2018-02-22 2024-02-22 Yes 2026-08-22 bepotastine besilate 179294 Bepreve Bausch and Lomb Incorporated N/A 2016-07-27 2022-07-27 Yes 2025-01-27 bictegravir 203718 Biktarvy Gilead Sciences Canada, Inc. N/A 2018-07-10 2024-07-10 Yes 2027-01-10 bilastine 184231 Blexten Aralez Pharmaceutials Canada is seroquel xr a benzodiazepine Inc. N/A 2016-04-21 2022-04-21 Yes 2024-10-21 binimetinib 237410 Mektovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 blinatumomab 181723 Blincyto Amgen Canada Incorporated N/A 2015-12-22 2021-12-22 Yes 2024-06-22 bosutinib 152211 Bosulif Pfizer Canada Inc.

N/A 2014-03-07 2020-03-07 N/A 2022-03-07 botulism antitoxin heptavalen C/ D/ F/ G - (equine) 190645 Bat Emergent BioSolutions Inc. N/A 2016-12-08 2022-12-08 Yes 2025-06-08 brexpiprazole 192684 Rexulti Otsuka Pharmaceutical is seroquel xr a benzodiazepine Co. Ltd. N/A 2017-02-16 2023-02-16 Yes 2025-08-16 brexucabtagene autoleucel 246355 Tecartus Gilead Sciences Canada, Inc.

N/A 2021-06-08 2027-06-08 N/A is seroquel xr a benzodiazepine 2029-06-08 brigatinib 210369 Alunbrig Takeda Canada Incorporated N/A 2018-07-26 2024-07-26 N/A 2026-07-26 brivaracetam 183355 Brivlera UCB Canada Incorporated N/A 2016-03-09 2022-03-09 Yes 2024-09-09 brodalumab 195317 Siliq Bausch Health, Canada Inc. N/A 2018-03-06 2024-03-06 N/A 2026-03-06 brolucizumab 226224 Beovu Novartis Pharmaceuticals Canada Inc. N/A 2020-03-12 2026-03-12 N/A 2028-03-12 bromfenac sodium sesquihydrate 171657 Prolensa Bausch &. Lomb Incorporated N/A 2015-03-26 2021-03-26 N/A 2023-03-26 burosumab 216239 Crysvita Kyowa Kirin Limited N/A 2018-12-05 2024-12-05 Yes 2027-06-05 cabotegravir sodium 227315 Vocabria is seroquel xr a benzodiazepine ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabotegravir 227315 Cabenuva ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabozantinib (supplied as cabozantinib (S)-malate) 206230 Cabometyx Ipsen Biopharmaceuticals Canada Inc.

N/A 2018-09-14 2024-09-14 N/A 2026-09-14 calcifediol 205392 Rayaldee Vifor Fresenius Medical Care Renal Pharma Ltd N/A 2018-07-10 2024-07-10 N/A 2026-07-10 canagliflozin 157505 Invokana Janssen Inc. InvokametInvokamet XR 2014-05-23 2020-05-23 N/A 2022-05-23 caplacizumab 230001 Cablivi Sanofi-Aventis Canada Inc. N/A 2020-02-28 is seroquel xr a benzodiazepine 2026-02-28 N/A 2028-02-28 carfilzomib 184479 Kyprolis Amgen Canada Inc. N/A 2016-01-15 2022-01-15 N/A 2024-01-15 carglumic acid 171358 Carbaglu Recordati Rare Diseases N/A 2015-04-10 2021-04-10 Yes 2023-10-10 cedazuridine 234610 Inqovi Otsuka Pharmaceutical Co., Ltd.

N/A 2020-07-07 2026-07-07 N/A 2028-07-07 ceftolozane 178006 Zerbaxa Merck Canada Inc. N/A 2015-09-30 2021-09-30 N/A 2023-09-30 cemiplimab 218718 Libtayo is seroquel xr a benzodiazepine Sanofi-Aventis Canada Inc. N/A 2019-04-10 2025-04-10 N/A 2027-04-10 cenegermin 218145 Oxervate Dompé farmaceutici S.p.A. N/A 2019-02-08 2025-02-08 N/A 2027-02-08 ceritinib 175702 Zykadia Novartis Pharmaceuticals Canada Inc.

N/A 2015-03-27 2021-03-27 N/A 2023-03-27 cerliponase alfa 216539 Brineura Biomarin International Limited N/A 2018-12-19 2024-12-19 Yes 2027-06-19 coagulation factor IX (recombinant), albumin fusion protein (rIX-FP) is seroquel xr a benzodiazepine 180793 Idelvion CSL Behring Canada Inc. N/A 2016-01-26 2022-01-26 Yes 2024-07-26 coagulation factor IX (recombinant), pegylated (nonacog beta pegol) 201114 Rebinyn Novo Nordisk Canada Inc. N/A 2017-11-29 2023-11-29 Yes 2026-05-29 coagulation factor IX, Fc fusion protein 163614 Alprolix Sanofi-Aventis Canada Inc. N/A 2014-03-20 2020-03-20 Yes 2022-09-20 cobimetinib 182788 Cotellic Hoffmann-La Roche Limited N/A 2016-02-22 2022-02-22 N/A 2024-02-22 crisaborole 206906 is seroquel xr a benzodiazepine Eucrisa Pfizer Canada Inc.

N/A 2018-06-07 2024-06-07 Yes 2026-12-07 cysteamine bitartrate 191347 Procysbi Horizon Pharma Ireland Ltd. N/A 2017-06-13 2023-06-13 Yes 2025-12-13 daclatasvir 172616 Daklinza Bristol-Myers Squibb Canada N/A 2015-08-13 2021-08-13 N/A 2023-08-13 daclizumab beta 190458 Zinbryta Biogen Canada Inc. N/A 2016-12-08 2022-12-08 N/A 2024-12-08 is seroquel xr a benzodiazepine dacomitinib 214572 Vizimpro Pfizer Canada Inc. N/A 2019-02-26 2025-02-26 N/A 2027-02-26 dalbavancin (supplied as dalbavancin hydrochloride) 212390 Xydalba Cipher Pharmaceuticals Inc.

N/A 2018-09-04 2024-09-04 N/A 2026-09-04 dapagliflozin propanediol 160877 Forxiga AstraZeneca Canada Inc. XigduoQtern 2014-12-12 is seroquel xr a benzodiazepine 2020-12-12 N/A 2022-12-12 daratumumab 187648 Darzalex Janssen Inc. Darzalex SC 2016-06-29 2022-06-29 N/A 2024-06-29 darolutamide 226146 Nubeqa Bayer Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 deferiprone 162924 Ferriprox Chiesi Canada Corp.

N/A 2015-02-13 2021-02-13 Yes 2023-08-13 defibrotide sodium 200808 Defitelio Jazz Pharmaceuticals Ireland Limited N/A 2017-07-10 2023-07-10 Yes 2026-01-10 difluprednate 154517 is seroquel xr a benzodiazepine Durezol Novartis Pharmaceuticals Canada Inc. N/A 2013-11-04 2019-11-04 Yes 2022-05-04 dimethyl fumarate 154776 Tecfidera Biogen Idec Canada Inc. N/A 2013-04-03 2019-04-03 Yes 2021-10-03 dinutuximab 212066 Unituxin United Therapeutics Corporation N/A 2018-11-28 2024-11-28 Yes 2027-05-28 dolutegravir sodium 161084 Tivicay ViiV Healthcare ULC TriumeqJulucaDovato 2013-10-31 2019-10-31 Yes 2022-05-01 doravirine 211293 Pifeo Merck Canada Inc. Delstrigo 2018-10-12 2024-10-12 N/A 2026-10-12 dulaglutide 168671 is seroquel xr a benzodiazepine Trulicity Eli Lilly Canada Inc.

N/A 2015-11-10 2021-11-10 N/A 2023-11-10 dupilumab 201285 Dupixent Sanofi-Aventis Canada Inc. N/A 2017-11-30 2023-11-30 Yes 2026-05-30 durvalumab 202953 Imfinzi AstraZeneca Canada Inc. N/A 2017-11-03 2023-11-03 N/A 2025-11-03 edaravone 214391 Radicava Mitsubishi Tanabe is seroquel xr a benzodiazepine Pharma Corporation N/A 2018-10-03 2024-10-03 N/A 2026-10-03 edoxaban 187363 Lixiana Servier Canada Inc. N/A 2016-11-04 2022-11-04 N/A 2024-11-04 efinaconazole 159416 Jublia Bausch Health, Canada Inc.

N/A 2013-10-02 2019-10-02 N/A 2021-10-02 elagolix 209513 Orilissa AbbVie Corporation N/A 2018-10-05 2024-10-05 N/A 2026-10-05 elexacaftor 246955 Trikafta Vertex Pharmaceuticals (Canada) Incorporated N/A 2021-06-18 2027-06-18 Yes 2029-12-18 eliglustat tartrate 183050 Cerdelga Genzyme Canada, A division of Sanofi-aventis Canada Inc. N/A 2017-04-21 2023-04-21 N/A 2025-04-21 elosulfase alfa 170340 Vimizim Biomarin International Limited N/A 2014-07-02 2020-07-02 Yes 2023-01-02 elotuzumab 188144 Empliciti Bristol-Myers Squibb Canada N/A 2016-06-21 is seroquel xr a benzodiazepine 2022-06-21 N/A 2024-06-21 eluxadoline 190162 Viberzi Allergan inc. N/A 2017-01-26 2023-01-26 N/A 2025-01-26 emicizumab 212635 Hemlibra Hoffmann-La Roche Limited N/A 2018-08-02 2024-08-02 Yes 2027-02-02 empagliflozin 162552 Jardiance Boehringer Ingelheim (Canada) Ltd. SynjardyGlyxambi 2015-07-23 2021-07-23 N/A 2023-07-23 enasidenib mesylate 217033 Idhifa Celgene Inc.

N/A 2019-02-06 2025-02-06 N/A 2027-02-06 encorafenib is seroquel xr a benzodiazepine 237413 Braftovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 entrectinib 227517 Rozlytrek Hoffmann-La Roche Limited N/A 2020-02-10 2026-02-10 Yes 2028-08-10 eptinezumab 233288 Vyepti Lundbeck Canada Inc. N/A 2021-01-11 2027-01-11 N/A 2029-01-11 erdafitinib 224529 Balversa Janssen Inc. N/A 2019-10-25 2025-10-25 N/A 2027-10-25 erenumab 208607 Aimovig Novartis Pharmaceuticals Canada Inc. N/A 2018-08-01 2024-08-01 N/A 2026-08-01 ertugliflozin 204724 Steglatro Merck Canada Inc is seroquel xr a benzodiazepine.

SteglujanSegluromet 2018-05-09 2024-05-09 N/A 2026-05-09 eslicarbazepine acetate 165665 Aptiom Sunovion Pharmaceuticals Canada Inc. N/A 2014-07-08 2020-07-08 Yes 2023-01-08 estetrol monohydrate 236197 Nextstellis Searchlight Pharma Inc. N/A 2021-03-05 is seroquel xr a benzodiazepine 2027-03-05 N/A 2029-03-05 evolocumab 178234 Repatha Amgen Canada Inc. N/A 2015-09-10 2021-09-10 Yes 2024-03-10 fedratinib (supplied as fedratinib hydrochloride) 229866 Inrebic Celgene Inc.

N/A 2020-07-27 2026-07-27 N/A 2028-07-27 ferric pyrophosphate citrate 239850 Triferic Avnu Rockwell Medical Inc. N/A 2021-04-22 is seroquel xr a benzodiazepine 2027-04-22 Yes 2029-10-22 finafloxacin 172450 Xtoro MerLion Pharmaceuticals GmbH N/A 2016-03-11 2022-03-11 Yes 2024-09-11 flibanserin 189352 Addyi Searchlight Pharma Inc. N/A 2018-02-27 2024-02-27 N/A 2026-02-27 florbetaben (18F) 193105 Neuraceq Isologic Innovative Radiopharmaceuticals Ltd. N/A 2017-02-22 2023-02-22 N/A 2025-02-22 follitropin delta 188743 Rekovelle Ferring Inc.

N/A 2018-03-22 2024-03-22 N/A 2026-03-22 fostamatinib (supplied as fostamatinib disodium) 232078 Tavalisse Rigel Pharmaceuticals is seroquel xr a benzodiazepine Inc. N/A 2020-11-19 2026-11-19 N/A 2028-11-19 fremanezumab 226828 Ajovy Teva Canada Limited N/A 2020-04-09 2026-04-09 N/A 2028-04-09 gadoterate meglumine 186333 Dotarem Guerbet N/A 2016-11-26 2022-11-26 Yes 2025-05-26 galcanezumab 219521 Emgality Eli Lilly Canada Inc. N/A 2019-07-30 2025-07-30 N/A 2027-07-30 galsulfase 159020 Naglazyme BioMarin Pharmaceutical Inc. N/A 2013-09-16 2019-09-16 Yes 2022-03-16 gemtuzumab ozogamicin 223091 Mylotarg Pfizer Canada ULC N/A 2019-11-28 2025-11-28 Yes 2028-05-28 gilteritinib is seroquel xr a benzodiazepine fumarate 227918 Xospata Astellas Pharma Canada Inc.

N/A 2019-12-23 2025-12-23 N/A 2027-12-23 givosiran (supplied as givosiran sodium) 237194 Givlaari Alnylam Netherlands B.V.. N/A 2020-10-09 2026-10-09 N/A 2028-10-09 glasdegib 225793 Daurismo Pfizer Canada ULC N/A 2020-04-28 2026-04-28 N/A 2028-04-28 glecaprevir, pibrentasvir 202233 Maviret AbbVie Corporation N/A 2017-08-16 2023-08-16 Yes 2026-02-16 glycerol phenylbutyrate 174219 Ravicti Horizon Pharma Ireland Ltd. N/A 2016-03-18 2022-03-18 Yes 2024-09-18 grazoprevir, elbasvir 185866 Zepatier Merck Canada Inc is seroquel xr a benzodiazepine. N/A 2016-01-19 2022-01-19 N/A 2024-01-19 guanfacine hydrochloride 150741 Intuniv XR Takeda Canada Inc.

N/A 2013-07-05 2019-07-05 Yes 2022-01-05 guselkumab 200590 Tremfya Janssen Inc. N/A 2017-11-10 2023-11-10 N/A 2025-11-10 haemagglutinin strain A (H5N1) 115398 Arepanrix H5N1 ID Biomedical Corporation of Quebec N/A 2013-02-13 2019-02-13 Yes 2021-08-13 hemin is seroquel xr a benzodiazepine 212276 Panhematin Recordati Rare Diseases Canada Inc. N/A 2018-07-13 2024-07-13 N/A 2026-07-13 ibrutinib 174029 Imbruvica Janssen Inc. N/A 2014-11-17 2020-11-17 Yes 2023-05-17 icatibant acetate 162918 Firazyr Takeda Canada Inc.

N/A 2014-06-04 2020-06-04 Yes 2022-12-04 icosapent ethyl 227235 is seroquel xr a benzodiazepine Vascepa HLS Therapeutics Inc. N/A 2019-12-30 2025-12-30 N/A 2027-12-30 idarucizumab 182503 Praxbind Boehringer Ingelheim (Canada) Ltd N/A 2016-04-29 2022-04-29 N/A 2024-04-29 idecabtagene vicleucel 244266 Abecma Celgene Inc. N/A 2021-05-26 2027-05-26 N/A 2029-05-26 idelalisib 172652 Zydelig Gilead Sciences Canada Inc. N/A 2015-03-27 is seroquel xr a benzodiazepine 2021-03-27 N/A 2023-03-27 inotersen sodium 214274 Tegsedi Akcea Therapeutics Inc.

N/A 2018-10-03 2024-10-03 N/A 2026-10-03 inotuzumab ozogamicin 204077 Besponsa Pfizer Canada Inc. N/A 2018-03-15 2024-03-15 N/A 2026-03-15 insulin degludec 198124 Tresiba Novo Nordisk Canada Inc. Xultophy 2017-08-25 2023-08-25 Yes 2026-02-25 ioflupane (123I) 201481 Datscan GE Healthcare Canada Inc is seroquel xr a benzodiazepine. N/A 2017-12-07 2023-12-07 N/A 2025-12-07 iron isomaltoside 1000 193890 Monoferric Pharmacosmos A/S N/A 2018-06-22 2024-06-22 N/A 2026-06-22 isatuximab 229245 Sarclisa Sanofi-Aventis Canada Inc.

N/A 2020-04-29 2026-04-29 N/A 2028-04-29 isavuconazole (supplied as isavuconazonium sulfate) 208919 Cresemba Avir Pharma Inc. N/A 2018-12-19 2024-12-19 N/A 2026-12-19 ivabradine hydrochloride 166949 Lancora Servier is seroquel xr a benzodiazepine Canada Inc. N/A 2016-12-23 2022-12-23 Yes 2025-06-23 ivermectin 172733 Rosiver Galderma Canada Inc. N/A 2015-04-22 2021-04-22 N/A 2023-04-22 ixazomib (supplied as ixazomib citrate) 190498 Ninlaro Takeda Canada Inc.

N/A 2016-08-04 is seroquel xr a benzodiazepine 2022-08-04 N/A 2024-08-04 ixekizumab 184993 Taltz Eli Lilly Canada Inc. N/A 2016-05-25 2022-05-25 Yes 2024-11-25 lanadelumab 213920 Takhzyro Takeda Canada Inc. N/A 2018-09-19 2024-09-19 Yes 2027-03-19 larotrectinib (supplied as larotrectinib sulfate) 219998 Vitrakvi Bayer Inc. N/A 2019-07-10 2025-07-10 Yes 2028-01-10 latanoprostene bunod 211732 is seroquel xr a benzodiazepine Vyzulta Bausch &.

Lomb Incorporated N/A 2018-12-27 2024-12-27 N/A 2026-12-27 ledipasvir 173180 Harvoni Gilead Sciences Canada Inc. N/A 2014-10-15 2020-10-15 Yes 2023-04-15 lefamulin acetate 233292 Xenleta Sunovion Pharmaceuticals Canada Inc. N/A 2020-07-10 2026-07-10 N/A 2028-07-10 lemborexant 231286 Dayvigo Eisai Limited N/A 2020-11-04 2026-11-04 N/A 2028-11-04 is seroquel xr a benzodiazepine lenvatinib mesylate 180877 Lenvima Eisai Limited N/A 2015-12-22 2021-12-22 N/A 2023-12-22 letermovir 204165 Prevymis Merck Canada Inc. N/A 2017-11-01 2023-11-01 N/A 2025-11-01 levomilnacipran hydrochloride 167319 Fetzima Allergan Inc.

N/A 2015-05-08 2021-05-08 N/A 2023-05-08 lifitegrast 199810 Xiidra Novartis Pharmaceuticals Canada Inc. N/A 2017-12-22 is seroquel xr a benzodiazepine 2023-12-22 N/A 2025-12-22 linaclotide 161056 Constella Forest Laboratories Canada Inc. N/A 2013-12-02 2019-12-02 N/A 2021-12-02 lixisenatide 193862 Adlyxine Sanofi-aventis Canada Inc. Soliqua 2017-05-25 2023-05-25 N/A 2025-05-25 lomitapide mesylate 160385 Juxtapid Aegerion Pharmaceuticals Canada Ltd.

N/A 2014-02-04 2020-02-04 N/A 2022-02-04 lorlatinib 215733 Lorbrena is seroquel xr a benzodiazepine Pfizer Canada ULC N/A 2019-02-22 2025-02-22 N/A 2027-02-22 lubiprostone 179333 Amitiza Sucampo Pharma Americas LLC N/A 2015-10-14 2021-10-14 N/A 2023-10-14 lumacaftor 181715 Orkambi Vertex Pharmaceuticals (Canada) Incorporated N/A 2016-01-26 2022-01-26 Yes 2024-07-26 luspatercept 236441 Reblozyl Celgene Inc. N/A 2020-09-25 2026-09-25 N/A 2028-09-25 lutetium177 Lu oxodotreotide 217184 Lutathera Advanced Accelerator Applications USA, Inc. N/A 2019-01-09 2025-01-09 N/A 2027-01-09 macitentan 161372 Opsumit Janssen Inc. N/A 2013-11-06 2019-11-06 Yes 2022-05-06 mecasermin 235023 Increlex Ipsen Biopharmaceuticals Canada is seroquel xr a benzodiazepine Inc.

N/A 2020-12-17 2026-12-17 Yes 2029-06-17 mepolizumab 179850 Nucala GlaxoSmithKline Inc. N/A 2015-12-03 2021-12-03 Yes 2024-06-03 midostaurin 201101 Rydapt Novartis Pharmaceuticals Canada Inc. N/A 2017-07-21 2023-07-21 Yes 2026-01-21 mifepristone 160063 Mifegymiso Linepharma International is seroquel xr a benzodiazepine Limited N/A 2015-07-29 2021-07-29 Yes 2024-01-29 migalastat hydrochloride 196956 Galafold Amicus Therapeutics UK LTD N/A 2017-09-05 2023-09-05 N/A 2025-09-05 modified vaccinia seroquel (ankara-bavarian nordic) 144762 Imvamune Bavarian Nordic A/S N/A 2013-11-21 2019-11-21 N/A 2021-11-21 naloxegol oxalate 167790 Movantik Knight Therapeutics Inc. N/A 2015-06-02 2021-06-02 N/A 2023-06-02 necitumumab 193689 Portrazza Eli Lilly Canada Inc.

N/A 2017-03-16 2023-03-16 N/A 2025-03-16 neisseria meningitidis serogroup A polysaccharide, neisseria meningitidis serogroup C polysaccharide, neisseria meningitidis serogroup W-135 polysaccharide, neisseria meningitidis serogroup Y polysaccharide, conjugated to tetanus toxoid carrier protein 154290 Nimenrix Pfizer Canada Inc. N/A 2013-03-05 2019-03-05 Yes 2021-09-05 neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily A and Neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) is seroquel xr a benzodiazepine subfamily B 195550 Trumenba Pfizer Canada Inc. N/A 2017-10-05 2023-10-05 Yes 2026-04-05 neratinib maleate 218224 Nerlynx Knight Therapeutics Inc. N/A 2019-07-16 2025-07-16 N/A 2027-07-16 netupitant 196495 Akynzeo Elvium Life Sciences N/A 2017-09-28 2023-09-28 N/A 2025-09-28 nintedanib (supplied as nintedanib esilate) 176043 Ofev Boehringer Ingelheim (Canada) Ltd N/A 2015-06-25 2021-06-25 N/A 2023-06-25 niraparib 216792 Zejula GlaxoSmithKline Inc.

N/A 2019-06-27 2025-06-27 N/A 2027-06-27 nivolumab 180828 Opdivo Bristol-Myers-Squibb Canada N/A 2015-09-25 2021-09-25 is seroquel xr a benzodiazepine Yes 2024-03-25 nusinersen 200070 Spinraza Biogen Canada Inc. N/A 2017-06-29 2023-06-29 Yes 2025-12-29 obeticholic acid 198418 Ocaliva Intercept Pharmaceuticals Inc. N/A 2017-05-24 2023-05-24 N/A 2025-05-24 obiltoxaximab 230825 Anthim Elusys Therapeutics, Inc. N/A 2020-07-30 2026-07-30 N/A 2028-07-30 obinutuzumab 168227 Gazyva Hoffmann-La Roche Limited N/A 2014-11-25 is seroquel xr a benzodiazepine 2020-11-25 N/A 2022-11-25 ocrelizumab 198094 Ocrevus Hoffmann-La Roche Limited N/A 2017-08-14 2023-08-14 N/A 2025-08-14 ocriplasmin 161356 Jetrea ThromboGenics N.V.

N/A 2013-08-13 2019-08-13 N/A 2021-08-13 olaparib 182823 Lynparza AstraZeneca Canada Inc. N/A 2016-04-29 2022-04-29 N/A 2024-04-29 olaratumab 203478 Lartruvo Eli Lilly Canada Inc. N/A 2017-11-23 2023-11-23 N/A 2025-11-23 ombitasvir, paritaprevir, dasabuvir sodium 174739 Holkira Pak Abbvie Corporation Technivie 2014-12-22 2020-12-22 N/A 2022-12-22 onasemnogene abeparvovec is seroquel xr a benzodiazepine 239719 Zolgensma Novartis Pharmaceuticals Canada Inc. N/A 2020-12-15 2026-12-15 Yes 2029-06-15 osimertinib mesylate 188171 Tagrisso AstraZeneca Canada Inc.

N/A 2016-07-05 2022-07-05 N/A 2024-07-05 ozanimod (supplied as ozanimod hydrochloride) 232761 Zeposia Celgene Inc. N/A 2020-10-02 2026-10-02 N/A 2028-10-02 is seroquel xr a benzodiazepine ozenoxacin 192925 Ozanex Ferrer Internacional, S.A. N/A 2017-05-01 2023-05-01 Yes 2025-11-01 palbociclib 182048 Ibrance Pfizer Canada Inc. N/A 2016-03-16 2022-03-16 N/A 2024-03-16 pasireotide diaspartate 145005 Signifor Novartis Pharmaceuticals Canada Inc.

Signifor Lar 2013-09-23 2019-09-23 N/A 2021-09-23 patiromer sorbitex calcium 210368 Veltassa Vifor Fresenius Medical Care is seroquel xr a benzodiazepine Renal Pharma Ltd. N/A 2018-10-03 2024-10-03 N/A 2026-10-03 patisiran (as patisiran sodium) 221896 Onpattro Alnylam Netherlands B.V. N/A 2019-06-07 2025-06-07 N/A 2027-06-07 peginterferon beta-1a 166974 Plegridy Biogen Idec Canada Inc. N/A 2015-08-10 2021-08-10 N/A 2023-08-10 pembrolizumab is seroquel xr a benzodiazepine 175884 Keytruda Merck Canada Inc.

N/A 2015-05-19 2021-05-19 Yes 2023-11-19 peramivir 191280 Rapivab BioCryst Pharmaceuticals Inc. N/A 2017-01-05 2023-01-05 N/A 2025-01-05 perampanel 153747 Fycompa Eisai Limited N/A 2013-04-04 2019-04-04 Yes 2021-10-04 pitolisant hydrochloride 238175 Wakik Endo Ventures Ltd. N/A 2021-05-25 2027-05-25 N/A 2029-05-25 plecanatide 215288 Trulance Bausch Health, Canada is seroquel xr a benzodiazepine Inc. N/A 2019-10-10 2025-10-10 N/A 2027-10-10 polatuzumab vedotin 232303 Polivy Hoffmann-La Roche Limited N/A 2020-07-09 2026-07-09 N/A 2028-07-09 polidocanol 177359 Varithena Provensis Ltd.

N/A 2015-08-04 2021-08-04 N/A 2023-08-04 pomalidomide 165891 Pomalyst Celgene Inc. N/A 2014-01-20 2020-01-20 Yes 2022-07-20 pralatrexate 207545 Folotyn Servier Canada is seroquel xr a benzodiazepine Inc. N/A 2018-10-26 2024-10-26 N/A 2026-10-26 pralsetinib 243731 Gavreto Hoffmann-La Roche Limited N/A 2021-06-30 2027-06-30 N/A 2029-06-30 prasterone 198822 Intrarosa Endoceutics Inc. N/A 2019-11-01 2025-11-01 N/A 2027-11-01 ponatinib hydrochloride 165121 Iclusig Ariad Pharmaceuticals Inc.

N/A 2015-04-02 2021-04-02 N/A is seroquel xr a benzodiazepine 2023-04-02 ponesimod 239537 Ponvory Janssen Inc. N/A 2021-04-28 2027-04-28 N/A 2029-04-28 propiverine hydrochloride 188323 Mictoryl / Mictoryl Pediatric Duchesnay Inc. N/A 2017-01-05 2023-01-05 Yes 2025-07-05 radium - 223 dichloride 161312 Xofigo Bayer Inc. N/A 2013-12-12 is seroquel xr a benzodiazepine 2019-12-12 N/A 2021-12-12 ramucirumab 176810 Cyramza Eli Lilly Canada Inc.

N/A 2015-07-16 2021-07-16 N/A 2023-07-16 ravulizumab 217955 Ultomiris Alexion Pharma GmbH N/A 2019-08-28 2025-08-28 N/A 2027-08-28 recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) 235672 Supemtek Sanofi Pasteur Limited N/A 2021-01-14 2027-01-14 N/A 2029-01-14 recombinant human papillomaseroquel types 31, 33, 45, 52 and 58 170006 Gardasil 9 Merck Canada Inc. N/A 2015-02-05 2021-02-05 Yes 2023-08-05 recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) 147275 Bexsero GlaxoSmithKline Inc. N/A 2013-12-06 2019-12-06 Yes 2022-06-06 is seroquel xr a benzodiazepine recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) 177290 Obizur Takeda Canada Inc. N/A 2015-10-14 2021-10-14 N/A 2023-10-14 regorafenib monohydrate 157970 Stivarga Bayer Inc.

N/A 2013-03-11 2019-03-11 Yes 2021-09-11 remdesivir 240551 Veklury Gilead Sciences Canada, Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 reslizumab 185873 Cinqair Teva Canada Limited N/A 2016-07-20 2022-07-20 Yes 2025-01-20 ribociclib (supplied as ribociclib succinate) 203884 Kisqali Novartis is seroquel xr a benzodiazepine Pharmaceuticals Canada Inc. N/A 2018-03-02 2024-03-02 N/A 2026-03-02 rifaximin 161256 Zaxine Salix Pharmaceuticals Inc. N/A 2013-08-13 2019-08-13 N/A 2021-08-13 riociguat 162761 Adempas Bayer Inc.

N/A 2013-09-19 2019-09-19 N/A 2021-09-19 ripretinib 234688 Qinlock Deciphera Pharmaceuticals, LLC N/A 2020-06-19 2026-06-19 N/A 2028-06-19 risankizumab 215753 Skyrizi AbbVie Corporation N/A 2019-04-17 2025-04-17 N/A 2027-04-17 risdiplam 242373 Evrysdi Hoffman-La Roche Limited is seroquel xr a benzodiazepine N/A 2021-04-14 2027-04-14 Yes 2029-10-14 romidepsin 152293 Istodax Celgene Inc. N/A 2013-10-16 2019-10-16 N/A 2021-10-16 romosozumab 197713 Evenity Amgen Canada Inc. N/A 2019-06-17 2025-06-17 N/A 2027-06-17 rupatadine (supplied as rupatadine fumarate) 186488 Rupall Medexus Pharmaceuticals Inc. N/A 2016-07-20 2022-07-20 Yes 2025-01-20 sacubitril 182734 Entresto Novartis Pharmaceuticals Canada Inc is seroquel xr a benzodiazepine.

N/A 2015-10-02 2021-10-02 N/A 2023-10-02 safinamide (as safinamide mesylate) 207115 Onstryv Valeo Pharma Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 sarilumab 191745 Kevzara Sanofi-aventis Canada Inc. N/A 2017-01-12 2023-01-12 N/A 2025-01-12 satralizumab 233642 Enspryng Hoffmann-La Roche Limited N/A 2020-06-01 2026-06-01 Yes 2028-12-01 sebelipase alfa 204085 Kanuma Alexion Pharma GmbH N/A 2017-12-15 2023-12-15 Yes is seroquel xr a benzodiazepine 2026-06-15 secukinumab 170732 Cosentyx Novartis Pharmaceuticals Canada Inc. N/A 2015-02-27 2021-02-27 Yes 2023-08-27 selexipag 182114 Uptravi Janssen Inc.

N/A 2016-01-20 2022-01-20 N/A 2024-01-20 selpercatinib 243748 Retevmo Loxo Oncology Inc. N/A 2021-06-15 2027-06-15 Yes 2029-12-15 semaglutide 202059 is seroquel xr a benzodiazepine Ozempic Novo Nordisk Canada Inc. Rybelsus 2018-01-04 2024-01-04 N/A 2026-01-04 siltuximab 174291 Sylvant EUSA Pharma (UK) Limited N/A 2014-12-03 2020-12-03 N/A 2022-12-03 simeprevir 164021 Galexos Janssen Inc. N/A 2013-11-18 2019-11-18 N/A 2021-11-18 siponimod 223225 Mayzent Novartis Pharmaceuticals Canada Inc.

N/A 2020-02-20 2026-02-20 N/A 2028-02-20 sodium zirconium cyclosilicate 218799 is seroquel xr a benzodiazepine Lokelma AstraZeneca Canada Inc. N/A 2019-07-25 2025-07-25 N/A 2027-07-25 sofosbuvir 165043 Sovaldi Gilead Sciences Canada Inc. HarvoniEpclusaVosevi 2013-12-13 2019-12-13 N/A 2021-12-13 solriamfetol hydrochloride 237511 Sunosi Jazz Pharmaceuticals Ireland Ltd. N/A 2021-05-13 2027-05-13 N/A 2029-11-13 sonidegib phosphate 229407 Odomzo Sun Pharma Global FZE N/A 2020-06-12 2026-06-12 N/A 2028-06-12 sucroferric oxyhydroxide 201492 Velphoro Vifor is seroquel xr a benzodiazepine Fresenius Medical Care Renal Pharma Ltd.

N/A 2018-01-05 2024-01-05 N/A 2026-01-05 sugammadex sodium 180385 Bridion Merck Canada Inc. N/A 2016-02-05 2022-02-05 N/A 2024-02-05 suvorexant 196367 Belsomra Merck Canada Inc. N/A 2018-11-29 2024-11-29 N/A 2026-11-29 tafamidis meglumine 228368 Vyndaqel Pfizer Canada ULC Vyndamax 2020-01-20 2026-01-20 N/A 2028-01-20 tafluprost 165596 Saflutan Purdue Pharma N/A 2014-05-26 2020-05-26 N/A 2022-05-26 talazoparib is seroquel xr a benzodiazepine (supplied as talazoparib tosylate) 220584 Talzenna Pfizer Canada ULC N/A 2019-09-06 2025-09-06 N/A 2027-09-06 taliglucerase alfa 140854 Elelyso Pfizer Canada Inc. N/A 2014-05-29 2020-05-29 Yes 2022-11-29 tedizolid phosphate 173603 Sivextro Merck Canada Inc.

N/A 2015-03-17 2021-03-17 N/A 2023-03-17 teduglutide 180223 Revestive Takeda Canada Inc. N/A 2015-09-04 2021-09-04 Yes 2024-03-04 telotristat ethyl (as is seroquel xr a benzodiazepine telotristat etiprate) 208730 Xermelo Ipsen Biopharmaceuticals Canada Inc. N/A 2018-10-10 2024-10-10 N/A 2026-10-10 tenapanor hydrochloride 224850 Ibsrela Knight Therapeutics Inc. N/A 2020-04-15 2026-04-15 N/A 2028-04-15 tenofovir alafenamide hemifumarate 181399 Genvoya Gilead Sciences Canada Inc.

DescovyOdefseyVemlidySymtuzaBiktarvy 2015-11-27 2021-11-27 Yes 2024-05-27 tepotinib (supplied as tepotinib hydrochloride) 242300 Tepmetko EMD Serono, a Division of EMD Inc., Canada N/A 2021-05-27 2027-05-27 N/A 2029-05-27 teriflunomide 160646 Aubagio Genzyme Canada a division of is seroquel xr a benzodiazepine Sanofi-aventis Canada Inc. N/A 2013-11-14 2019-11-14 Yes 2022-05-14 tesamorelin 131836 Egrifta Theratechnologies Inc. N/A 2014-04-29 2020-04-29 N/A 2022-04-29 tezacaftor 211292 Symdeko Vertex Pharmaceuticals (Canada) Incorporated N/A 2018-06-27 2024-06-27 Yes 2026-12-27 tildrakizumab 224036 Ilumya Sun Pharma Global FZE N/A 2021-05-19 2027-05-19 N/A 2029-05-19 tisagenlecleucel 213547 / 213698 Kymriah Novartis Pharmaceuticals Canada Inc. N/A 2018-09-05 2024-09-05 Yes 2027-03-05 is seroquel xr a benzodiazepine tofacitinib 154642 Xeljanz Pfizer Canada Inc.

N/A 2014-04-17 2020-04-17 Yes 2022-10-17 trametinib 157665 Mekinist Novartis Pharmaceuticals Canada Inc. N/A 2013-07-18 2019-07-18 N/A 2021-07-18 trastuzumab deruxtecan 242104 Enhertu AstraZeneca Canada Inc. N/A 2021-04-15 2027-04-15 N/A 2029-04-15 trastuzumab emtansine 162414 Kadcyla Hoffmann-La Roche Limited N/A 2013-09-11 2019-09-11 N/A 2021-09-11 trifarotene 221945 Aklief Galderma Canada is seroquel xr a benzodiazepine Inc. N/A 2019-11-25 2025-11-25 Yes 2028-05-25 tipiracil hydrochloride 205852 Lonsurf Taiho Pharma Canada Inc.

N/A 2018-01-25 2024-01-25 N/A 2026-01-25 triheptanoin 242196 Dojolvi Uagenyx Pharmaceutical Inc. N/A 2021-02-15 2027-02-15 Yes 2029-08-15 tucatinib 235295 Tukysa Seagen Inc is seroquel xr a benzodiazepine. N/A 2020-06-05 2026-06-05 N/A 2028-06-05 turoctocog alfa 170796 Zonovate Novo Nordisk Canada Inc. N/A 2014-12-08 2020-12-08 Yes 2023-06-08 umeclidinium bromide 161585 Anoro Ellipta GlaxoSmithKline Inc.

Incruse Ellipta 2013-12-23 2019-12-23 N/A 2021-12-23 upadacitinib 223734 Rinvoq AbbVie Corporation N/A 2019-12-23 is seroquel xr a benzodiazepine 2025-12-23 N/A 2027-12-23 varicella-zoster seroquel glycoprotein E (gE) 200244 Shingrix GlaxoSmithKline Inc. N/A 2017-10-13 2023-10-13 N/A 2025-10-13 vedolizumab 169414 Entyvio Takeda Canada Inc. N/A 2015-01-29 2021-01-29 Yes 2023-07-29 velpatasvir 190521 Epclusa Gilead Sciences Canada Inc. Vosevi 2016-07-11 2022-07-11 Yes 2025-01-11 venetoclax 190761 Venclexta AbbVie Corporation N/A 2016-09-30 2022-09-30 N/A 2024-09-30 vernakalant hydrochloride is seroquel xr a benzodiazepine 190817 Brinavess Cipher Pharmaceuticals Inc.

N/A 2017-03-13 2023-03-13 N/A 2025-03-13 vilanterol trifenatate 157301 Breo Ellipta GlaxoSmithKline Inc. Anoro ElliptaTrelegy Ellipta 2013-07-03 2019-07-03 Yes 2022-01-03 vilazodone hydrochloride 176820 Viibryd Allergan Inc. N/A 2015-07-16 2021-07-16 is seroquel xr a benzodiazepine Yes 2024-01-16 von willebrand factor (recombinant) (vonicog alfa) 213188 Vonvendi Takeda Canada Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 vorapaxar sulfate 179320 Zontivity Toprol Acquisition LLC N/A 2016-05-13 2022-05-13 N/A 2024-05-13 voretigene neparvovec 233097 Luxturna Novartis Pharmaceuticals Canada Inc.

N/A 2020-10-13 2026-10-13 Yes 2029-04-13 vortioxetine hydrobromide 159019 Trintellix Lundbeck Canada Inc. N/A 2014-10-22 2020-10-22 Yes is seroquel xr a benzodiazepine 2023-04-22 voxilaprevir 202324 Vosevi Gilead Sciences Canada Inc. N/A 2017-08-16 2023-08-16 N/A 2025-08-16 zanubrutinib 242748 Brukinsa BeiGene Switzerland GmbH N/A 2021-03-01 2027-03-01 N/A 2029-03-01On this page June 2021Product Monograph Brand Safety Updates June 2021(PDF, 101 KB, 4 pages) June 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &.

Precautions Adverse Reactions is seroquel xr a benzodiazepine Drug Interactions Dosage &. Administration Overdosage Consumer Information Altace HCT 246597 Hydrochlorothiazide, Ramipril Bausch Health, Canada Inc No Yes No Yes No No No Yes Aspirin 81 mg, Aspirin 81 mg Quick Chews, Aspirin Regular Strength, Aspirin Extra Strength 248124 Acetylsalicylic Acid Bayer Inc No Yes No Yes Yes No No No Bricanyl Turbuhaler 239089 Terbutaline Sulfate AstraZeneca Canada Inc Yes Yes No No No No No Yes Cellcept, Cellcept I.V. 248429 Mycophenolate Mofetil Hoffmann-La Roche Limited No Yes No No No No No Yes Cipro XL 248371 Ciprofloxacin Hydrochloride Bayer Inc Yes No No No No Yes No Yes Cipro, Cipro Oral Suspension 248370 Ciprofloxacin Hydrochloride Bayer Inc Yes No No No No Yes No Yes Clozaril 247538 Clozapine HLS Therapeutics Inc No Yes Yes No No Yes No Yes Combogesic 248697 Ibuprofen, Acetaminophen Biosyent Pharma Inc No No No Yes No Yes No No Efudex 246337 Fluorouracil Bausch Health, Canada Inc Yes Yes Yes Yes Yes Yes Yes Yes Epclusa 247195 Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Erleada 241210 Apalutamide Janssen Inc No Yes No Yes No Yes No Yes Harvoni 247194 Ledipasvir, Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Hemangiol 247151 Propranolol Hcl Pierre Fabre Dermo-Cosmetique Canada Inc No Yes No Yes No No No Yes Idamycin PFS 249085 Idarubicin Hcl Pfizer Canada ULC No No No Yes No No No Yes Imbruvica 248172 Ibrutinib Janssen Inc No Yes No Yes No No No Yes Inderal-LA 248972 Propranolol Hcl Pfizer Canada ULC No No No Yes No No No Yes Jakavi 247787 Ruxolitinib Phosphate Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Lorbrena 247174 Lorlatinib Pfizer Canada ULC No Yes No Yes No Yes No Yes Lynparza 249369 Olaparib AstraZeneca Canada Inc No No No Yes No No No Yes Manerix 246047 Moclobemide Bausch Health, Canada Inc Yes Yes No Yes Yes Yes Yes Yes Maxidol Liquid Gels 248432 Naproxen Sodium Bayer Inc No No No Yes No No No Yes Nerlynx 242449 Neratinib Maleate Knight Therapeutics Inc No Yes No Yes Yes Yes No Yes Ofev 241747 Nintedanib Boehringer Ingelheim (Canada) Ltd Ltee No Yes No No Yes No No Yes Orgalutran 248614 Ganirelix Acetate Organon Canada Inc Yes Yes No Yes No Yes No Yes Pat-Galantamine ER 248978 Galantamine Hydrobromide Janssen Inc No Yes No Yes No Yes No Yes Piqray 248616 Alpelisib Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Ralivia 246159 Tramadol Hcl Bausch Health, Canada Inc No Yes No Yes No No Yes Yes Retrovir (AZT) 249459 Zidovudine ViiV Healthcare ULC No Yes Yes No Yes Yes Yes Yes Rinvoq 241253 Upadacitinib Abbvie Corporation No Yes No Yes No Yes No Yes Rivotril 245341 Clonazepam Hoffmann-La Roche Limited No Yes Yes Yes Yes Yes No Yes Rydapt 247829 Midostaurin Novartis Pharmaceuticals Canada Inc No No No Yes No No No Yes Sandoz Zopiclone Tablet 247527 Zopiclone Sandoz Canada Incorporated No Yes Yes Yes No Yes No Yes Sovaldi 247196 Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Synalar 247002 Fluocinolone Acetonide Bausch Health, Canada Inc No Yes No Yes No No No Yes Tapazole 246350 Methimazole Paladin Labs Inc No Yes No No No No Yes Yes Toviaz 248542 Fesoterodine Fumarate Pfizer Canada ULC Yes Yes No Yes Yes Yes No No Trileptal 247670 Oxcarbazepine Novartis Pharmaceuticals Canada Inc No Yes No No No Yes No Yes Valium 245343 Diazepam Hoffmann-La Roche Limited No Yes Yes Yes Yes Yes No Yes Vaseretic 247516 Enalapril Maleate, Hydrochlorothiazide Organon Canada Inc No Yes No No Yes No No Yes Vasotec 247519 Enalapril Maleate Organon Canada Inc No Yes No No Yes No No Yes Wellbutrin XL 247849 Bupropion Hcl Bausch Health, Canada Inc Yes Yes No Yes Yes Yes Yes Yes Zyban 247564 Bupropion Hcl Bausch Health, Canada Inc Yes Yes No Yes Yes Yes Yes Yes Zyvoxam 248930 Linezolid Pfizer Canada ULC No Yes No Yes No Yes No Yes May 2021Product Monograph Brand Safety Updates May 2021(PDF, 90 KB, 2 pages) May 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings is seroquel xr a benzodiazepine &.

Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Afinitor, Afinitor Disperz 247570 Everolimus Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Androcur, Androcur Depot 245903 Cyproterone Acetate Bayer Inc No Yes No Yes No No No Yes Apo-Clobazam 245505 Clobazam Apotex Inc No Yes Yes Yes Yes Yes No Yes Ativan 245317 Lorazepam Pfizer Canada ULC No Yes Yes Yes Yes Yes No Yes Aubagio 247354 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No No No Yes No No No Yes Biktarvy 240953 Emtricitabine, Bictegravir Sodium, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc No Yes No Yes No Yes No Yes Ceftriaxone Sodium for Injection 246728 Ceftriaxone Sodium Teva Canada Limited No No No Yes No No No Yes Depakene 247699 Valproic Acid BGP Pharma ULC No Yes No Yes No No No Yes Diastat 245322 Diazepam Valeant Pharmaceuticals North America Llc No Yes Yes Yes Yes Yes No Yes Diazepam Injection USP 245324 Diazepam Sandoz Canada Incorporated Yes Yes Yes Yes Yes Yes No Yes Epival 247581 Divalproex Sodium BGP Pharma ULC No Yes No Yes No No No Yes Eucrisa 240171 Crisaborole Pfizer Canada ULC No No No No Yes No No Yes Lorazepam Injection USP 245339 Lorazepam Sandoz Canada Incorporated No Yes Yes Yes Yes Yes No Yes Mayzent 245078 Siponimod Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Ofev 247352 Nintedanib Boehringer Ingelheim (Canada) Ltd Ltee No Yes No Yes Yes Yes Yes Yes Prinivil 247696 Lisinopril Merck Canada Inc No Yes No No Yes No No Yes Sevorane AF 246821 Sevoflurane Abbvie Corporation No Yes No Yes No No No Yes Soliqua 247226 Lixisenatide, Insulin Glargine Sanofi-Aventis Canada Inc No Yes No Yes No Yes No Yes Tegretol 247229 Carbamazepine Novartis Pharmaceuticals Canada Inc Yes Yes Yes Yes Yes Yes Yes Yes Toloxin 246803 Digoxin Pendopharm Division of Pharmascience Inc No No No No No Yes No Yes Topamax 247698 Topiramate Janssen Inc Yes Yes No No Yes Yes Yes Yes Trelegy Ellipta 240101 Umeclidinium Bromide, Fluticasone Furoate, Vilanterol Trifenatate GlaxoSmithKline Inc Yes Yes No Yes Yes Yes Yes Yes Vitrakvi 241249 Larotrectinib Sulfate Bayer Inc No Yes No Yes Yes Yes No No Vosevi 247191 Voxilaprevir, Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Xanax,Xanax TS 245344 Alprazolam Upjohn Canada ULC No Yes Yes Yes Yes Yes No Yes Xylocard 246218 Lidocaine Hcl Aspen Pharmacare Canada Inc. Yes Yes No is seroquel xr a benzodiazepine No No Yes Yes Yes April 2021Product Monograph Brand Safety Updates April 2021(PDF, 84.6 KB, 2 pages) April 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &.

Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Avalide 246609 Hydrochlorothiazide, Irbesartan Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Avapro 246866 Irbesartan Sanofi-Aventis Canada Inc No No No Yes No No No Yes Docetaxel Injection USP 246984 Docetaxel Pfizer Canada ULC No Yes Yes Yes No No No Yes Duodopa 245733 Levodopa, Carbidopa Monohydrate AbbVie Corporation No Yes No No No Yes No Yes Hydromorphone Hydrochloride Injection USP 237401 Hydromorphone Hcl Sandoz Canada Incorporated No No No No No Yes Yes No Iressa 246584 Gefitinib AstraZeneca Canada Inc No No No Yes No No No Yes Kazano 243901 Metformin Hcl, Alogliptin Benzoate Takeda Canada Inc No No No Yes No No No Yes Naproxen Capsules200 Mg 245549 Naproxen Catalent Ontario Limited No Yes No Yes Yes No No Yes Nesina 243900 Alogliptin is seroquel xr a benzodiazepine Benzoate Takeda Canada Inc No Yes No Yes No No No Yes Nexplanon 247049 Etonogestrel Organon Canada Inc. No Yes No No No No No Yes Opsumit 246750 Macitentan Janssen Inc No No No No Yes No No Yes Reactine Fast Melt Junior 246339 Cetirizine Hydrochloride McNeil Consumer Healthcare Division of Johnson &. Johnson Inc No No No No No No No Yes Sandostatin, Sandostatin LAR 247160 Octreotide Novartis Pharmaceuticals Canada Inc No No No Yes No No Yes No Seroquel, Seroquel XR >246849 Quetiapine Fumarate AstraZeneca Canada Inc No Yes Yes Yes Yes Yes No Yes Sinemet 246915 Carbidopa Monohydrate, Levodopa Organon Canada Inc.

No No No No No Yes No Yes Vosevi >245142 Voxilaprevir, Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc is seroquel xr a benzodiazepine No Yes No Yes No No No Yes Xeloda 247293 Capecitabine Hoffmann La Roche Limited No No No Yes No No No Yes Zenhale 239493 Formoterol Fumarate Dihydrate, Mometasone Furoate Organon Canada Inc. No Yes No Yes No Yes No Yes March 2021Product Monograph Brand Safety Updates March 2021(PDF, 108 KB, 3 pages) March 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions is seroquel xr a benzodiazepine Dosage &.

Administration Overdosage Consumer Information Abilify Maintena 237149 Aripiprazole Otsuka Pharmaceutical Co Ltd No Yes No No No Yes No Yes Accuretic 244863 Hydrochlorothiazide, Quinapril Hcl Pfizer Canada ULC No Yes No Yes No No No Yes Aldactazide 25, Aldactazide 50 244911 Hydrochlorothiazide, Spironolactone Pfizer Canada ULC No Yes No Yes No No No Yes Alunbrig 237680 Brigatinib Takeda Canada Inc No Yes No Yes No No No Yes Asacol 245536 Mesalazine Allergan Inc No Yes No Yes Yes No No Yes Asacol 800 245722 Mesalazine Allergan Inc No Yes No Yes Yes No No Yes Balversa 245919 Erdafitinib Janssen Inc No No No No Yes No No No Belsomra 244781 Suvorexant Merck Canada Inc No Yes No Yes No No No Yes Buscopan 245198 Hyoscine Butylbromide Sanofi Consumer Health Inc Yes Yes No No No No Yes Yes Cellcept 245034 Mycophenolate Mofetil Hydrochloride, Mycophenolate Mofetil Hoffmann La Roche Limited No No No Yes No No No Yes Children's Advil 244560 Ibuprofen GlaxoSmithkKine Consumer Healthcare ULC No Yes No No No Yes No Yes Cymbalta 245810 Duloxetine Hcl Eli Lilly Canada Inc No Yes No No No No No Yes Flovent HFA, Flovent Diskus 243742 Fluticasone Propionate GlaxoSmithkKine Inc No Yes No Yes No Yes Yes Yes Gemcitabine Injection 245820 Gemcitabine Hcl Pfizer Canada ULC No Yes No Yes No No No No Glatect 244549 Glatiramer Acetate Pharmascience Inc No Yes No Yes No No No Yes Glyxambi 243907 Linagliptin, Empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee No No No Yes No No No Yes Imbruvica 238064 Ibrutinib Janssen Inc No Yes No Yes Yes No No Yes Invanz 245199 Ertapenem Sodium Merck Canada Inc No No No Yes No No No Yes Jentadueto 243906 Metformin Hcl, Linagliptin Boehringer Ingelheim (Canada) Ltd Ltee No No No Yes No No No Yes Jorveza 238101 Budesonide Avir Pharma Inc No No No Yes No Yes No Yes Lynparza 246316 Olaparib AstraZeneca Canada Inc No Yes No Yes No No No Yes Maviret 245141 Pibrentasvir, Glecaprevir Abbvie Corporation Yes Yes No Yes No No No Yes Mekinist 245843 Trametinib Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Motrin Liquid Gels 200 Mg, Motrin Liquid Gels 400 Mg 244305 Ibuprofen McNeil Consumer Healthcare Division of Johnson &. Johnson Inc No Yes No No No No No Yes Neupro 245289 Rotigotine UCB Canada Inc No Yes No Yes No No No Yes Nolvadex-D 243317 Tamoxifen Citrate AstraZeneca Canada Inc Yes Yes No Yes Yes No No No Octostim 244562 Desmopressin Acetate Ferring Inc Yes Yes No Yes Yes Yes Yes Yes Onbrez Breezhaler 245077 Indacaterol Maleate Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes No No Yes Onpattro 245256 Patisiran Sodium Alnylam Netherlands B.V. No Yes No Yes No No No Yes PMS-Methadone 241778 Methadone Hydrochloride Paladin Labs Inc Yes Yes Yes Yes Yes Yes Yes Yes Prevacid, Prevacid Fastab 241989 Lansoprazole Takeda Pharmaceuticals America Inc No Yes No Yes No No No No Radicava 245593 Edaravone Mitsubishi Tanabe Pharma Corporation No No No No No Yes No No Sandoz Methylphenidate SR 244991 Methylphenidate Hcl Sandoz Canada Incorporated No Yes No Yes No Yes No Yes Sandoz Perindopril Erbumine/Indapamide LD, Sandoz is seroquel xr a benzodiazepine Perindopril Erbumine/Indapamide, Sandoz Perindopril Erbumine/Indapamide HD 244537 Indapamide, Perindopril Erbumine Sandoz Canada Incorporated Yes Yes No Yes Yes No No Yes Septra Injection 245929 Trimethoprim, Sulfamethoxazole Aspen Pharmacare Canada Inc. No Yes Yes Yes No No No Yes Serevent Diskus 243734 Salmeterol Xinafoate GlaxoSmithKline Inc Yes Yes No Yes Yes Yes No Yes Solu-Medrol, Solu-Medrol Act-O-Vials 245362 Methylprednisolone Pfizer Canada ULC No Yes No No No No No No Somatuline Autogel 245315 Lanreotide Ipsen Biopharmaceuticals Canada Inc Yes Yes Yes Yes Yes Yes No Yes Tafinlar 245834 Dabrafenib Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Thalomid 244994 Thalidomide Celgene Inc No Yes No Yes No No No Yes Trintellix 237793 Vortioxetine Hydrobromide Lundbeck Canada Inc No Yes No Yes No No No Yes Viibryd 237588 Vilazodone Hydrochloride Allergan Inc No Yes No Yes No Yes No No Vocabria, Cabenuva 238803 Rilpivirine, Cabotegravir ViiV Healthcare ULC Yes Yes No Yes Yes Yes No Yes Zepatier 245140 Grazoprevir, Elbasvir Merck Canada Inc No Yes No Yes No No No Yes February 2021Product Monograph Brand Safety Updates February 2021(PDF, 83 KB, 2 pages) February 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &.

Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage is seroquel xr a benzodiazepine &. Administration Overdosage Consumer Information Abilify 242200 Aripiprazole Otsuka Pharmaceutical Co Ltd No Yes No Yes No No No Yes Aleve Caplets 243112 Naproxen Sodium Bayer Inc No No No No No Yes No Yes Aubagio 243821 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Belkyra 242465 Deoxycholic Acid Kythera Biopharmaceuticals Inc No Yes No Yes No No No Yes Biktarvy 237235 Emtricitabine, Bictegravir Sodium, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc No No No Yes No No No Yes Bridion 237151 Sugammadex Merck Canada Inc No Yes No Yes No No No No Clobex Spray 244309 Clobetasol Propionate Galderma Canada Inc Yes Yes No Yes No Yes Yes Yes Definity 242706 Perflutren Lantheus MI Canada Inc No Yes No No No No No No Depo-Medrol 245381 Methylprednisolone Acetate Pfizer Canada ULC No No No No No Yes No No Diflucan One 244031 Fluconazole Pfizer Canada ULC No No No No Yes No No Yes Metadol 241772 Methadone Hydrochloride Paladin Labs Inc No Yes No Yes Yes Yes No Yes Metadol-D 241773 Methadone Hydrochloride Paladin Labs Inc No Yes No Yes Yes Yes No Yes Mycobutin 244143 Rifabutin Pfizer Canada ULC No Yes No Yes No No No Yes Myleran 243043 Busulfan Aspen Pharmacare Canada Inc. No Yes No Yes No No No Yes Ninlaro 244191 Ixazomib Citrate Takeda Canada Inc No No No No No No Yes Yes Pomalyst 243491 Pomalidomide Celgene Inc No Yes Yes Yes Yes Yes Yes Yes Revatio 237407 Sildenafil Citrate Upjohn Canada ULC No No No Yes No No No No Sabril 244467 Vigabatrin Lundbeck Pharmaceuticals LLC No Yes No No No Yes No No Salofalk 242059 Mesalazine Aptalis Pharma Canada ULC No Yes No Yes Yes Yes No Yes Salofalk 242468 Mesalazine Aptalis Pharma Canada ULC No Yes No Yes Yes No No Yes Salofalk 242774 Mesalazine Aptalis Pharma Canada ULC No Yes No Yes Yes No No Yes Seasonale 245618 Levonorgestrel, Ethinyl Estradiol Teva Canada Limited Yes Yes Yes No No No No Yes Seasonique 245619 Levonorgestrel, Ethinyl Estradiol Teva Canada Limited Yes Yes Yes No No No No Yes Stieva-A 244142 Tretinoin GlaxoSmithKline Inc No Yes No No No Yes No Yes Symbicort Turbuhaler 244507 Formoterol Fumarate Dihydrate, Budesonide AstraZeneca Canada Inc No Yes No Yes Yes Yes Yes Yes Teveten Plus 244660 Hydrochlorothiazide, Eprosartan Mesylate BGP Pharma ULC No Yes No Yes No No No Yes Trajenta 243905 Linagliptin Boehringer Ingelheim (Canada) Ltd Ltee No No No Yes No No No Yes Trintellix 243819 Vortioxetine Hydrobromide Lundbeck Canada Inc No Yes No Yes Yes No No Yes Vfend 243931 Voriconazole Pfizer Canada ULC Yes No No No Yes No No Yes January 2021Product Monograph Brand Safety Updates January 2021(PDF, 83 KB, 2 pages) January 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &.

Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Addyi 229727 Flibanserin Searchlight Pharma Inc Yes Yes Yes Yes Yes Yes No Yes Aptivus 242983 Tipranavir Boehringer Ingelheim (Canada) Ltd Ltee No No No No Yes Yes No Yes Entocort Enema 242607 Budesonide Tillotts Pharma GmbH Yes Yes No No Yes Yes Yes Yes Fycompa 235549 Perampanel Eisai Limited No Yes No No Yes No No No Kyleena 243730 Levonorgestrel Bayer Inc No Yes No No No Yes No Yes Kyprolis 237196 Carfilzomib Amgen Canada Inc No Yes No Yes No Yes No Yes Micardis Plus 242123 Telmisartan, Hydrochlorothiazide Boehringer Ingelheim (Canada) Ltd Ltee Yes No No Yes Yes No No No Monistat Derm Cream 242581 Miconazole Nitrate Insight Pharmaceuticals LLC No Yes Yes No No No Yes Yes Omnipaque 180, Omnipaque 240, Omnipaque 300, Omnipaque 350 242219 Iohexol GE Healthcare Canada Inc No No No No No Yes No Yes Retin-A 235656 Tretinoin Bausch Health, Canada Inc. Yes Yes No Yes No Yes No Yes Rozlytrek 242028 Entrectinib Hoffmann La Roche Limited No No No Yes No Yes No Yes Sinemet 240018 Carbidopa, Levodopa Merck Canada Inc No No No No No Yes No No Tagrisso 243288 Osimertinib Mesylate AstraZeneca Canada Inc No Yes No Yes No Yes No Yes Tivicay 235583 Dolutegravir Sodium ViiV Healthcare ULC No Yes No Yes Yes Yes No Yes Trelstar 239594 Triptorelin Pamoate Knight Therapeutics Inc.

No No No No No No No Yes Venclexta 243474 Venetoclax Abbvie Corporation No Yes No No No Yes No Yes Xarelto 234756 Rivaroxaban Bayer Inc Yes Yes No Yes Yes Yes Yes Yes Xylac 243159 Loxapine Succinate Pendopharm Division of Pharmascience Inc No Yes Yes Yes Yes Yes No Yes Ziagen 243476 Abacavir Sulfate ViiV Healthcare ULC No No No No Yes No No Yes Zytiga 244273 Abiraterone Acetate Janssen Inc No Yes No Yes No No No Yes December 2020Product Monograph Brand Safety Updates December 2020(PDF, 103 KB, 3 pages) December 2020 Brand Name Submission Number Ingredient(S) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Abilify Maintena 242346 Aripiprazole Otsuka Pharmaceutical Co Ltd No Yes No Yes No No No No Accel-Sevelamer 239213 Sevelamer Carbonate Accel Pharma Inc No Yes No No No Yes Yes Yes Adderall XR 241496 Amphetamine Aspartate, Dextroamphetamine Saccharate, Amphetamine Sulfate, Dextroamphetamine Sulfate Takeda Canada Inc No Yes No No Yes No No Yes Advagraf 241431 Tacrolimus Astellas Pharma Canada Inc No No No No Yes No No Yes Asmanex Twisthaler 241482 Mometasone Furoate Merck Canada Inc No Yes No No No Yes Yes Yes Biktarvy 242750 Emtricitabine, Bictegravir Sodium, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc No No No Yes No No No Yes Caduet 241827 Atorvastatin Calcium, Amlodipine Besylate Upjohn Canada ULC Yes Yes No No Yes No No Yes Caripul 241742 Epoprostenol Sodium Janssen Inc No Yes No No No No No Yes Dexilant 241999 Dexlansoprazole Takeda Canada Inc No Yes No Yes No No No No Duotrav PQ 242431 Travoprost, Timolol Maleate Novartis Pharmaceuticals Canada Inc No No No Yes No No No Yes Erythrocin I.V.

241362 Erythromycin Lactobionate Amdipharm Limited Yes Yes Yes Yes Yes No No Yes Gilenya 242144 Fingolimod Hydrochloride Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes Yes No Yes Idhifa 242218 Enasidenib Mesylate Celgene Inc No No No No Yes No No No Imbruvica 235706 Ibrutinib Janssen Inc No Yes No Yes No Yes No Yes Invanz 238455 Ertapenem Sodium Merck Canada Inc No Yes No No No No No Yes Invega 241812 Paliperidone Janssen Inc No Yes No Yes No No No Yes Invega Sustenna 241862 Paliperidone Palmitate Janssen Inc No Yes No Yes No No No Yes Invega Trinza 241830 Paliperidone Palmitate Janssen Inc No Yes No Yes No No No Yes Keppra 242697 Levetiracetam UCB Canada Inc No Yes No Yes No No No Yes Kisqali 237555 Ribociclib Succinate Novartis Pharmaceuticals Canada Inc No No No Yes No No No No Lenvima 242453 Lenvatinib Mesylate Eisai Limited No Yes No Yes Yes Yes No Yes Lipitor 241951 Atorvastatin Calcium Upjohn Canada ULC Yes Yes No No Yes No No Yes Luvox 238347 Fluvoxamine Maleate BGP Pharma ULC No Yes No No No No No No Mavenclad 238626 Cladribine EMD Serono a Division of EMD Inc Canada Yes Yes No No No No No Yes Moviprep 238575 Polyethylene Glycol 3350, Sodium Chloride, Potassium Chloride, Ascorbic Acid, Sodium Ascorbate, Sodium Sulfate Anhydrous Aralez Pharmaceuticals Canada Inc No Yes No No No No No Yes Olmetec 241065 Olmesartan Medoxomil Merck Canada Inc Yes Yes No Yes Yes No No Yes Olmetec Plus 241145 Hydrochlorothiazide, Olmesartan Medoxomil Merck Canada Inc Yes Yes No No Yes No Yes Yes Onivyde 243509 Irinotecan Sucrose Octasulfate Servier Canada Inc No Yes No No No No No Yes Onstryv 242236 Safinamide Valeo Pharma Inc No No No Yes No No No Yes Pantoloc 242003 Pantoprazole Takeda Canada Inc No Yes No Yes No No No No Pediapred 243283 Prednisolone Sodium Phosphate Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Prograf 241489 Tacrolimus Astellas Pharma Canada Inc No No No No Yes Yes No Yes Prolensa 238790 Bromfenac Sodium Sesquihydrate Bausch &. Lomb Inc No Yes No Yes No No No Yes Remeron 242352 Mirtazapine Merck Canada Inc No Yes No Yes No No No Yes Remeron RD 242354 Mirtazapine Merck Canada Inc No Yes No Yes No No No Yes Rexulti 242419 Brexpiprazole Otsuka Pharmaceutical Co Ltd No Yes No Yes No No No Yes Rifadin 241843 Rifampin Sanofi-Aventis Canada Inc No No No No Yes No No Yes Risperdal 241861 Risperidone Janssen Inc No Yes No Yes No No No Yes Risperdal Consta 241839 Risperidone Janssen Inc No Yes No Yes No No No Yes Stribild 238174 Emtricitabine, Tenofovir Disoproxil Fumarate, Cobicistat, Elvitegravir Gilead Sciences Canada Inc Yes No No No No No No Yes Tecta 242002 Pantoprazole Magnesium Takeda Canada Inc No Yes No Yes No No No No Teva-Loperamide 240985 Loperamide Hcl Teva Canada Limited No Yes No No No No Yes Yes Uam 241841 Tramadol Hcl Janssen Inc No Yes No Yes No No No Yes November 2020Product Monograph Brand Safety Updates November 2020(PDF, 91 KB, 2 pages) November 2020 Brand Name Submission Number Ingredient(S) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Administration Overdosage Consumer Information Adlyxine 240740 Lixisenatide Sanofi-Aventis Canada Inc No No No No No Yes No Yes Advil Cold &. Sinus Convenience Pack 240564 Ibuprofen, Pseudoephedrine Hcl, Chlorpheniramine Maleate GlaxoSmithKline Consumer Healthcare Inc Yes Yes No No Yes No No Yes Advil Day/Night Convenience Pack 240575 Ibuprofen, Diphenhydramine Hcl GlaxoSmithKline Consumer Healthcare Inc Yes Yes No Yes Yes No Yes Yes Auro-Cefixime 239750 Cefixime Auro Pharma Inc No Yes No No No No No Yes Avalide 241361 Hydrochlorothiazide, Irbesartan Sanofi-Aventis Canada Inc No Yes No Yes Yes No No Yes Avapro 241360 Irbesartan Sanofi-Aventis Canada Inc No Yes No Yes Yes No No Yes Azarga 242484 Timolol Maleate, Brinzolamide Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Carbaglu 227936 Carglumic Acid Recordati Rare Diseases No Yes No Yes Yes Yes Yes Yes Claritin Kids Rapid Dissolve 228699 Loratadine Bayer Inc No No No No No Yes No Yes Cold + Sinus Daytime Cold + Sinus Nighttime 239435 Ibuprofen, Pseudoephedrine Hcl Vita Health Products Inc Yes Yes Yes No Yes No No Yes Depakene 242654 Valproic Acid BGP Pharma ULC No Yes No No No No No Yes Descovy 234525 Emtricitabine, Tenofovir Alafenamide Gilead Sciences Canada Inc No Yes Yes Yes No Yes No Yes Epclusa 233923 Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No Yes No Yes No Yes No Yes Epival 242651 Divalproex Sodium BGP Pharma ULC No Yes No No No No No Yes Erleada 241921 Apalutamide Janssen Inc No No No Yes No No No Yes Genvoya 238172 Emtricitabine, Tenofovir Alafenamide Hemifumarate, Cobicistat, Elvitegravir Gilead Sciences Canada Inc Yes No No No Yes No No Yes Jakavi 241484 Ruxolitinib Phosphate Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes No No Yes Lolo 238799 Ethinyl Estradiol, Norethindrone Acetate Allergan Inc No No No No No Yes No Yes Lonsurf 235999 Tipiracil Hydrochloride, Trifluridine Taiho Pharma Canada, Inc. No Yes No Yes No Yes No Yes Lupron, Lupron Depot 241744 Leuprolide Acetate Abbvie Corporation Yes Yes Yes Yes Yes Yes Yes Yes Micro+6 Concentrate 237994 Manganese Sulfate, Chromic Chloride, Cupric Sulfate, Selenious Acid, Zinc Sulfate Heptahydrate, Sodium Iodide Sandoz Canada Incorporated No Yes No No No Yes Yes No Mirena 243721 Levonorgestrel Bayer Inc No Yes No No No Yes No Yes PMS-Fluticasone Propionate/Salmeterol DPI 242762 Fluticasone Propionate, Salmeterol Xinafoate Pharmascience Inc No No No No No No No Yes Ravicti 241398 Glycerol Phenylbutyrate Horizon Therapeutics Ireland DAC No No No No No No No Yes Rydapt 241284 Midostaurin Novartis Pharmaceuticals Canada Inc No Yes No No No Yes No No Sandostatin LAR, Sandostatin 240998 Octreotide, Octreotide Acetate Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes Yes No Yes Sandoz Metoprolol SR 240568 Metoprolol Tartrate Sandoz Canada Incorporated No No No No Yes No No Yes Sofracort 240569 Dexamethasone Sodium Metasulphobenzoate, Gramicidin, Framycetin Sulfate Sanofi-Aventis Canada Inc Yes Yes No Yes Yes No Yes Yes Tagrisso 242157 Osimertinib Mesylate AstraZeneca Canada Inc No No No Yes No No No Yes Tasigna 242015 Nilotinib Hydrochloride Monohydrate Novartis Pharmaceuticals Canada Inc No No No Yes No No No Yes Tiazac XC 238542 Diltiazem Hcl Valeant Canada LP Valeant Canada S.E.C. Yes Yes No Yes No No Yes Yes Xarelto 233166 Rivaroxaban Bayer Inc No Yes No Yes No Yes No Yes Zytiga 241627 Abiraterone Acetate Janssen Inc No Yes No Yes Yes No No Yes October 2020Product Monograph Brand Safety Updates October 2020(PDF, 70KB, 1 page) October 2020 Brand Name Submission Number Ingredient(S) Manufacturer Contraindications Warnings &.

Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Aubagio 239626 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No Yes No Yes Yes No No Yes Elmiron 239842 Pentosan Polysulfate Sodium Janssen Inc Yes Yes Yes Yes No No No Yes Ibuprofen Liquid Filled Capsules, Extra Strength Ibuprofen Liquid Filled Capsules 240415 Ibuprofen Apotex Inc Yes Yes No No Yes No No Yes Imovane 240565 Zopiclone Sanofi-Aventis Canada Inc Yes Yes Yes Yes Yes No No Yes Ketalar 238402 Ketamine Hydrochloride ERFA Canada 2012 Inc Yes Yes No Yes No Yes No No Kisqali 233623 Ribociclib Succinate Novartis Pharmaceuticals Canada Inc No Yes No Yes No Yes No No Maviret 234362 Pibrentasvir, Glecaprevir Abbvie Corporation No No No No No Yes No No Plavix 239831 Clopidogrel Bisulfate Sanofi-Aventis Canada Inc No Yes No No Yes No No Yes Prezcobix 240107 Darunavir Ethanolate, Cobicistat Janssen Inc No No No No Yes No No Yes Prezista 240039 Darunavir Ethanolate Janssen Inc No No No No Yes No No Yes Renagel 238457 Sevelamer Hydrochloride Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Renvela 238461 Sevelamer Carbonate Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Salazopyrin, Salazopyrin En-Tabs 239257 Sulfasalazine Pfizer Canada ULC No No No Yes No No No No Symtuza 240432 Darunavir Ethanolate, Emtricitabine, Cobicistat, Tenofovir Alafenamide Hemifumarate Janssen Inc No No No No Yes No No Yes Tagrisso 234607 Osimertinib Mesylate AstraZeneca Canada Inc No Yes No Yes No Yes No No Talzenna 234108 Talazoparib Pfizer Canada ULC No Yes No Yes Yes Yes No No Tenormin 239845 Atenolol AstraZeneca Canada Inc No Yes No No No No No No Teva-Mexiletine 238065 Mexiletine Hcl Teva Canada Limited No Yes No No No No No No Twynsta 239007 Telmisartan, Amlodipine Besylate Boehringer Ingelheim (Canada) Ltd Ltee Yes Yes No Yes Yes No Yes Yes Zejula 237670 Niraparib GlaxoSmithKline Inc No Yes No Yes Yes Yes No Yes Zerbaxa 238477 Ceftolozane Sulfate, Tazobactam Sodium Merck Canada Inc No Yes No No No No No Yes Zofran, Zofran ODT 240200 Ondansetron Hydrochloride Dihydrate Novartis Pharmaceuticals Canada Inc No Yes No No No No No Yes September 2020Product Monograph Brand Safety Updates September 2020(PDF, 72 KB, 1 page) September 2020 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &.

Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Aubagio 231739 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Dovato 233469 Dolutegravir, Lamivudine ViiV Healthcare ULC No No No Yes No No No No Heartburn Control 238026 Omeprazole Apotex Inc Yes Yes No Yes Yes Yes Yes Yes Imbruvica 233164 Ibrutinib Janssen Inc No Yes No No No Yes No No Incruse Ellipta 222505 Umeclidinium Bromide GlaxoSmithKline Inc No No No No No No No Yes Narcan Nasal Spray 234832 Naloxone Hcl Adapt Pharma Operations Limited No No No No No No No Yes Plaquenil 238801 Hydroxychloroquine Sulfate Sanofi-Aventis Canada Inc Yes Yes No Yes Yes Yes Yes Yes Saphris 238694 Asenapine Merck Canada Inc No Yes No No No No No No Soliqua 232504 Lixisenatide, Insulin Glargine Sanofi-Aventis Canada Inc No No No Yes No Yes No Yes Synthroid 238350 Levothyroxine Sodium BGP Pharma ULC Yes Yes No No Yes Yes No Yes Targin 237753 Naloxone Hcl, Oxycodone Hcl Purdue Pharma Yes Yes Yes Yes Yes Yes Yes Yes Venclexta 234504 Venetoclax Abbvie Corporation No No No Yes No Yes No No Zytiga 236834 Abiraterone Acetate Janssen Inc No No No Yes No No No No August 2020Product Monograph Brand Safety Updates August 2020(PDF, 82 KB, 2 pages) August 2020 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Abemaciclib 215268 my blog Verzenio Eli Lilly Canada Inc seroquel 50mg cost. N/A 2019-04-08 2025-04-08 N/A 2027-04-08 acalabrutinib 214504 Calquence AstraZeneca Canada Inc. N/A 2019-08-23 2025-08-23 N/A 2027-08-23 aclidinium bromide 157598 Tudorza Genuair AstraZeneca Canada Inc. Duaklir Genuair 2013-07-29 2019-07-29 N/A 2021-07-29 afatinib seroquel 50mg cost dimaleate 158730 Giotrif Boehringer Ingelheim (Canada) Ltd. N/A 2013-11-01 2019-11-01 N/A 2021-11-01 aflibercept 149321 Eylea Bayer Inc.

N/A 2013-11-08 2019-11-08 N/A 2021-11-08 albiglutide 165145 Eperzan GlaxoSmithKline Inc. N/A 2015-07-15 2021-07-15 N/A 2023-07-15 alectinib hydrochloride 189442 Alecensaro Hoffmann-La Roche Limited N/A 2016-09-29 2022-09-29 N/A 2024-09-29 alirocumab 183116 Praluent seroquel 50mg cost Sanofi-aventis Canada Inc. N/A 2016-04-11 2022-04-11 N/A 2024-04-11 alogliptin benzoate 158335 Nesina Takeda Canada Inc. KazanoOseni 2013-11-27 2019-11-27 N/A 2021-11-27 alpelisib 226941 Piqray Novartis Pharmaceuticals Canada Inc. N/A 2020-03-11 2026-03-11 N/A 2028-03-11 amifampridine (supplied seroquel 50mg cost as amifampridine phosphate) 232685 Firdapse Kye Pharmaceuticals Inc.

N/A 2020-07-31 2026-07-31 N/A 2028-07-31 anthrax immune globulin (human) 200446 Anthrasil Emergent BioSolutions Canada Inc. N/A 2017-11-06 2023-11-06 Yes 2026-05-06 antihemophilic factor (recombinant BDD), Fc fusion protein 163447 Eloctate Sanofi-Aventis Canada Inc. N/A 2014-08-22 2020-08-22 Yes 2023-02-22 antihemophilic seroquel 50mg cost factor (recombinant), pegylated 189709 Adynovate Takeda Canada Inc. N/A 2016-11-17 2022-11-17 Yes 2025-05-17 antihemophilic factor (recombinant, B-domain deleted, pegylated) (also known as damoctocog alfa pegol) 210935 Jivi Bayer Inc. N/A 2018-10-18 2024-10-18 Yes 2027-04-18 antihemophilic factor (recombinant, B-domain deleted) (also known as simoctocog alfa) 169551 Nuwiq Octapharma Pharmazeutika Produktionsges.m.b.H N/A 2014-10-23 2020-10-23 Yes 2023-04-23 antihemophilic factor VIII (recombinant), singlechain (also known as lonoctocog alfa) 190891 Afstyla CSL Behring Canada Inc.

N/A 2016-12-12 2022-12-12 Yes 2025-06-12 anthrax antigen fiate 212387 Biothrax Emergent Biodefense Operations Lansing LLC N/A 2018-12-13 2024-12-13 N/A seroquel 50mg cost 2026-12-13 antihemophilic factor VIII (recombinant, B-domain truncated), PEGylated (turoctocog alfa pegol) 218531 Esperoct Novo Nordisk Canada Inc. N/A 2019-07-04 2025-07-04 Yes 2028-01-04 apalutamide 211942 Erleada Janssen Inc. N/A 2018-07-03 2024-07-03 N/A 2026-07-03 apremilast 169862 Otezla Amgen Canada Inc. N/A 2014-11-12 2020-11-12 N/A 2022-11-12 asfotase alfa 179340 Strensiq Alexion Pharma International Sàrl N/A 2015-08-14 2021-08-14 Yes 2024-02-14 asunaprevir 172617 Sunvepra Bristol-Myers Squibb Canada N/A 2016-03-09 2022-03-09 N/A 2024-03-09 atezolizumab 196843 Tecentriq Hoffmann-La Roche Limited N/A 2017-04-12 2023-04-12 N/A seroquel 50mg cost 2025-04-12 avelumab 204052 Bavencio EMD Serono, a Division of EMD Inc., Canada N/A 2017-12-18 2023-12-18 N/A 2025-12-18 axicabtagene ciloleucel 218389 Yescarta Gilead Sciences Canada Inc N/A 2019-02-13 2025-02-13 N/A 2027-02-13 azelastine hydrochloride 169604 Dymista Meda Pharmaceuticals Ltd. N/A 2014-10-23 2020-10-23 Yes 2023-04-23 baloxavir marboxil 227361 Xofluza Hoffmann-La Roche Limited N/A 2020-02-19 2026-02-19 Yes 2028-08-19 baricitinib 193687 Olumiant Eli Lilly Canada Inc.

N/A 2018-08-17 2024-08-17 N/A 2026-08-17 bazedoxifene acetate 160681 Duavive Pfizer Canada Inc. N/A 2014-10-23 2020-10-23 N/A 2022-10-23 benralizumab 204008 Fasenra AstraZeneca Canada seroquel 50mg cost Inc. N/A 2018-02-22 2024-02-22 Yes 2026-08-22 bepotastine besilate 179294 Bepreve Bausch and Lomb Incorporated N/A 2016-07-27 2022-07-27 Yes 2025-01-27 bictegravir 203718 Biktarvy Gilead Sciences Canada, Inc. N/A 2018-07-10 2024-07-10 Yes 2027-01-10 bilastine 184231 Blexten Aralez Pharmaceutials Canada Inc. N/A 2016-04-21 2022-04-21 Yes 2024-10-21 binimetinib 237410 Mektovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 seroquel 50mg cost N/A 2029-03-02 blinatumomab 181723 Blincyto Amgen Canada Incorporated N/A 2015-12-22 2021-12-22 Yes 2024-06-22 bosutinib 152211 Bosulif Pfizer Canada Inc.

N/A 2014-03-07 2020-03-07 N/A 2022-03-07 botulism antitoxin heptavalen C/ D/ F/ G - (equine) 190645 Bat Emergent BioSolutions Inc. N/A 2016-12-08 2022-12-08 Yes 2025-06-08 brexpiprazole 192684 Rexulti Otsuka Pharmaceutical Co. Ltd. N/A 2017-02-16 2023-02-16 Yes 2025-08-16 brexucabtagene autoleucel 246355 Tecartus Gilead Sciences Canada, Inc. N/A 2021-06-08 2027-06-08 N/A 2029-06-08 brigatinib 210369 Alunbrig Takeda Canada Incorporated N/A 2018-07-26 2024-07-26 N/A 2026-07-26 brivaracetam 183355 Brivlera UCB Canada Incorporated N/A 2016-03-09 2022-03-09 Yes 2024-09-09 brodalumab 195317 Siliq Bausch Health, Canada Inc.

N/A 2018-03-06 2024-03-06 N/A 2026-03-06 brolucizumab 226224 Beovu Novartis Pharmaceuticals Canada Inc. N/A 2020-03-12 2026-03-12 N/A 2028-03-12 bromfenac sodium sesquihydrate 171657 Prolensa Bausch &. Lomb Incorporated N/A 2015-03-26 2021-03-26 N/A 2023-03-26 burosumab 216239 Crysvita Kyowa Kirin Limited N/A 2018-12-05 2024-12-05 Yes 2027-06-05 cabotegravir sodium 227315 Vocabria ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabotegravir 227315 Cabenuva ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabozantinib (supplied as cabozantinib (S)-malate) 206230 Cabometyx Ipsen Biopharmaceuticals Canada Inc. N/A 2018-09-14 2024-09-14 N/A 2026-09-14 calcifediol 205392 Rayaldee Vifor Fresenius Medical Care Renal Pharma Ltd N/A 2018-07-10 2024-07-10 N/A 2026-07-10 canagliflozin 157505 Invokana Janssen Inc. InvokametInvokamet XR 2014-05-23 2020-05-23 N/A 2022-05-23 caplacizumab 230001 Cablivi Sanofi-Aventis Canada Inc.

N/A 2020-02-28 2026-02-28 N/A 2028-02-28 carfilzomib 184479 Kyprolis Amgen Canada Inc. N/A 2016-01-15 2022-01-15 N/A 2024-01-15 carglumic acid 171358 Carbaglu Recordati Rare Diseases N/A 2015-04-10 2021-04-10 Yes 2023-10-10 cedazuridine 234610 Inqovi Otsuka Pharmaceutical Co., Ltd. N/A 2020-07-07 2026-07-07 N/A 2028-07-07 ceftolozane 178006 Zerbaxa Merck Canada Inc. N/A 2015-09-30 2021-09-30 N/A 2023-09-30 cemiplimab 218718 Libtayo Sanofi-Aventis Canada Inc. N/A 2019-04-10 2025-04-10 N/A 2027-04-10 cenegermin 218145 Oxervate Dompé farmaceutici S.p.A.

N/A 2019-02-08 2025-02-08 N/A 2027-02-08 ceritinib 175702 Zykadia Novartis Pharmaceuticals Canada Inc. N/A 2015-03-27 2021-03-27 N/A 2023-03-27 cerliponase alfa 216539 Brineura Biomarin International Limited N/A 2018-12-19 2024-12-19 Yes 2027-06-19 coagulation factor IX (recombinant), albumin fusion protein (rIX-FP) 180793 Idelvion CSL Behring Canada Inc. N/A 2016-01-26 2022-01-26 Yes 2024-07-26 coagulation factor IX (recombinant), pegylated (nonacog beta pegol) 201114 Rebinyn Novo Nordisk Canada Inc. N/A 2017-11-29 2023-11-29 Yes 2026-05-29 coagulation factor IX, Fc fusion protein 163614 Alprolix Sanofi-Aventis Canada Inc. N/A 2014-03-20 2020-03-20 Yes 2022-09-20 cobimetinib 182788 Cotellic Hoffmann-La Roche Limited N/A 2016-02-22 2022-02-22 N/A 2024-02-22 crisaborole 206906 Eucrisa Pfizer Canada Inc.

N/A 2018-06-07 2024-06-07 Yes 2026-12-07 cysteamine bitartrate 191347 Procysbi Horizon Pharma Ireland Ltd. N/A 2017-06-13 2023-06-13 Yes 2025-12-13 daclatasvir 172616 Daklinza Bristol-Myers Squibb Canada N/A 2015-08-13 2021-08-13 N/A 2023-08-13 daclizumab beta 190458 Zinbryta Biogen Canada Inc. N/A 2016-12-08 2022-12-08 N/A 2024-12-08 dacomitinib 214572 Vizimpro Pfizer Canada Inc. N/A 2019-02-26 2025-02-26 N/A 2027-02-26 dalbavancin (supplied as dalbavancin hydrochloride) 212390 Xydalba Cipher Pharmaceuticals Inc. N/A 2018-09-04 2024-09-04 N/A 2026-09-04 dapagliflozin propanediol 160877 Forxiga AstraZeneca Canada Inc.

XigduoQtern 2014-12-12 2020-12-12 N/A 2022-12-12 daratumumab 187648 Darzalex Janssen Inc. Darzalex SC 2016-06-29 2022-06-29 N/A 2024-06-29 darolutamide 226146 Nubeqa Bayer Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 deferiprone 162924 Ferriprox Chiesi Canada Corp. N/A 2015-02-13 2021-02-13 Yes 2023-08-13 defibrotide sodium 200808 Defitelio Jazz Pharmaceuticals Ireland Limited N/A 2017-07-10 2023-07-10 Yes 2026-01-10 difluprednate 154517 Durezol Novartis Pharmaceuticals Canada Inc. N/A 2013-11-04 2019-11-04 Yes 2022-05-04 dimethyl fumarate 154776 Tecfidera Biogen Idec Canada Inc.

N/A 2013-04-03 2019-04-03 Yes 2021-10-03 dinutuximab 212066 Unituxin United Therapeutics Corporation N/A 2018-11-28 2024-11-28 Yes 2027-05-28 dolutegravir sodium 161084 Tivicay ViiV Healthcare ULC TriumeqJulucaDovato 2013-10-31 2019-10-31 Yes 2022-05-01 doravirine 211293 Pifeo Merck Canada Inc. Delstrigo 2018-10-12 2024-10-12 N/A 2026-10-12 dulaglutide 168671 Trulicity Eli Lilly Canada Inc. N/A 2015-11-10 2021-11-10 N/A 2023-11-10 dupilumab 201285 Dupixent Sanofi-Aventis Canada Inc. N/A 2017-11-30 2023-11-30 Yes 2026-05-30 durvalumab 202953 Imfinzi AstraZeneca Canada Inc. N/A 2017-11-03 2023-11-03 N/A 2025-11-03 edaravone 214391 Radicava Mitsubishi Tanabe Pharma Corporation N/A 2018-10-03 2024-10-03 N/A 2026-10-03 edoxaban 187363 Lixiana Servier Canada Inc.

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N/A 2019-02-06 2025-02-06 N/A 2027-02-06 encorafenib 237413 Braftovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 entrectinib 227517 Rozlytrek Hoffmann-La Roche Limited N/A 2020-02-10 2026-02-10 Yes 2028-08-10 eptinezumab 233288 Vyepti Lundbeck Canada Inc. N/A 2021-01-11 2027-01-11 N/A 2029-01-11 erdafitinib 224529 Balversa Janssen Inc. N/A 2019-10-25 2025-10-25 N/A 2027-10-25 erenumab 208607 Aimovig Novartis Pharmaceuticals Canada Inc. N/A 2018-08-01 2024-08-01 N/A 2026-08-01 ertugliflozin 204724 Steglatro Merck Canada Inc. SteglujanSegluromet 2018-05-09 2024-05-09 N/A 2026-05-09 eslicarbazepine acetate 165665 Aptiom Sunovion Pharmaceuticals Canada Inc.

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N/A 2013-09-16 2019-09-16 Yes 2022-03-16 gemtuzumab ozogamicin 223091 Mylotarg Pfizer Canada ULC N/A 2019-11-28 2025-11-28 Yes 2028-05-28 gilteritinib fumarate 227918 Xospata Astellas Pharma Canada Inc. N/A 2019-12-23 2025-12-23 N/A 2027-12-23 givosiran (supplied as givosiran sodium) 237194 Givlaari Alnylam Netherlands B.V.. N/A 2020-10-09 2026-10-09 N/A 2028-10-09 glasdegib 225793 Daurismo Pfizer Canada ULC N/A 2020-04-28 2026-04-28 N/A 2028-04-28 glecaprevir, pibrentasvir 202233 Maviret AbbVie Corporation N/A 2017-08-16 2023-08-16 Yes 2026-02-16 glycerol phenylbutyrate 174219 Ravicti Horizon Pharma Ireland Ltd. N/A 2016-03-18 2022-03-18 Yes 2024-09-18 grazoprevir, elbasvir 185866 Zepatier Merck Canada Inc. N/A 2016-01-19 2022-01-19 N/A 2024-01-19 guanfacine hydrochloride 150741 Intuniv XR Takeda Canada Inc.

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N/A 2019-12-30 2025-12-30 N/A 2027-12-30 idarucizumab 182503 Praxbind Boehringer Ingelheim (Canada) Ltd N/A 2016-04-29 2022-04-29 N/A 2024-04-29 idecabtagene vicleucel 244266 Abecma Celgene Inc. N/A 2021-05-26 2027-05-26 N/A 2029-05-26 idelalisib 172652 Zydelig Gilead Sciences Canada Inc. N/A 2015-03-27 2021-03-27 N/A 2023-03-27 inotersen sodium 214274 Tegsedi Akcea Therapeutics Inc. N/A 2018-10-03 2024-10-03 N/A 2026-10-03 inotuzumab ozogamicin 204077 Besponsa Pfizer Canada Inc. N/A 2018-03-15 2024-03-15 N/A 2026-03-15 insulin degludec 198124 Tresiba Novo Nordisk Canada Inc.

Xultophy 2017-08-25 2023-08-25 Yes 2026-02-25 ioflupane (123I) 201481 Datscan GE Healthcare Canada Inc. N/A 2017-12-07 2023-12-07 N/A 2025-12-07 iron isomaltoside 1000 193890 Monoferric Pharmacosmos A/S N/A 2018-06-22 2024-06-22 N/A 2026-06-22 isatuximab 229245 Sarclisa Sanofi-Aventis Canada Inc. N/A 2020-04-29 2026-04-29 N/A 2028-04-29 isavuconazole (supplied as isavuconazonium sulfate) 208919 Cresemba Avir Pharma Inc. N/A 2018-12-19 2024-12-19 N/A 2026-12-19 ivabradine hydrochloride 166949 Lancora Servier Canada Inc. N/A 2016-12-23 2022-12-23 Yes 2025-06-23 ivermectin 172733 Rosiver Galderma Canada Inc.

N/A 2015-04-22 2021-04-22 N/A 2023-04-22 ixazomib (supplied as ixazomib citrate) 190498 Ninlaro Takeda Canada Inc. N/A 2016-08-04 2022-08-04 N/A 2024-08-04 ixekizumab 184993 Taltz Eli Lilly Canada Inc. N/A 2016-05-25 2022-05-25 Yes 2024-11-25 lanadelumab 213920 Takhzyro Takeda Canada Inc. N/A 2018-09-19 2024-09-19 Yes 2027-03-19 larotrectinib (supplied as larotrectinib sulfate) 219998 Vitrakvi Bayer Inc. N/A 2019-07-10 2025-07-10 Yes 2028-01-10 latanoprostene bunod 211732 Vyzulta Bausch &.

Lomb Incorporated N/A 2018-12-27 2024-12-27 N/A 2026-12-27 ledipasvir 173180 Harvoni Gilead Sciences Canada Inc. N/A 2014-10-15 2020-10-15 Yes 2023-04-15 lefamulin acetate 233292 Xenleta Sunovion Pharmaceuticals Canada Inc. N/A 2020-07-10 2026-07-10 N/A 2028-07-10 lemborexant 231286 Dayvigo Eisai Limited N/A 2020-11-04 2026-11-04 N/A 2028-11-04 lenvatinib mesylate 180877 Lenvima Eisai Limited N/A 2015-12-22 2021-12-22 N/A 2023-12-22 letermovir 204165 Prevymis Merck Canada Inc. N/A 2017-11-01 2023-11-01 N/A 2025-11-01 levomilnacipran hydrochloride 167319 Fetzima Allergan Inc. N/A 2015-05-08 2021-05-08 N/A 2023-05-08 lifitegrast 199810 Xiidra Novartis Pharmaceuticals Canada Inc.

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N/A 2016-04-29 2022-04-29 N/A 2024-04-29 olaratumab 203478 Lartruvo Eli Lilly Canada Inc. N/A 2017-11-23 2023-11-23 N/A 2025-11-23 ombitasvir, paritaprevir, dasabuvir sodium 174739 Holkira Pak Abbvie Corporation Technivie 2014-12-22 2020-12-22 N/A 2022-12-22 onasemnogene abeparvovec 239719 Zolgensma Novartis Pharmaceuticals Canada Inc. N/A 2020-12-15 2026-12-15 Yes 2029-06-15 osimertinib mesylate 188171 Tagrisso AstraZeneca Canada Inc. N/A 2016-07-05 2022-07-05 N/A 2024-07-05 ozanimod (supplied as ozanimod hydrochloride) 232761 Zeposia Celgene Inc. N/A 2020-10-02 2026-10-02 N/A 2028-10-02 ozenoxacin 192925 Ozanex Ferrer Internacional, S.A.

N/A 2017-05-01 2023-05-01 Yes 2025-11-01 palbociclib 182048 Ibrance Pfizer Canada Inc. N/A 2016-03-16 2022-03-16 N/A 2024-03-16 pasireotide diaspartate 145005 Signifor Novartis Pharmaceuticals Canada Inc. Signifor Lar 2013-09-23 2019-09-23 N/A 2021-09-23 patiromer sorbitex calcium 210368 Veltassa Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-10-03 2024-10-03 N/A 2026-10-03 patisiran (as patisiran sodium) 221896 Onpattro Alnylam Netherlands B.V. N/A 2019-06-07 2025-06-07 N/A 2027-06-07 peginterferon beta-1a 166974 Plegridy Biogen Idec Canada Inc.

N/A 2015-08-10 2021-08-10 N/A 2023-08-10 pembrolizumab 175884 Keytruda Merck Canada Inc. N/A 2015-05-19 2021-05-19 Yes 2023-11-19 peramivir 191280 Rapivab BioCryst Pharmaceuticals Inc. N/A 2017-01-05 2023-01-05 N/A 2025-01-05 perampanel 153747 Fycompa Eisai Limited N/A 2013-04-04 2019-04-04 Yes 2021-10-04 pitolisant hydrochloride 238175 Wakik Endo Ventures Ltd. N/A 2021-05-25 2027-05-25 N/A 2029-05-25 plecanatide 215288 Trulance Bausch Health, Canada Inc. N/A 2019-10-10 2025-10-10 N/A 2027-10-10 polatuzumab vedotin 232303 Polivy Hoffmann-La Roche Limited N/A 2020-07-09 2026-07-09 N/A 2028-07-09 polidocanol 177359 Varithena Provensis Ltd.

N/A 2015-08-04 2021-08-04 N/A 2023-08-04 pomalidomide 165891 Pomalyst Celgene Inc. N/A 2014-01-20 2020-01-20 Yes 2022-07-20 pralatrexate 207545 Folotyn Servier Canada Inc. N/A 2018-10-26 2024-10-26 N/A 2026-10-26 pralsetinib 243731 Gavreto Hoffmann-La Roche Limited N/A 2021-06-30 2027-06-30 N/A 2029-06-30 prasterone 198822 Intrarosa Endoceutics Inc. N/A 2019-11-01 2025-11-01 N/A 2027-11-01 ponatinib hydrochloride 165121 Iclusig Ariad Pharmaceuticals Inc. N/A 2015-04-02 2021-04-02 N/A 2023-04-02 ponesimod 239537 Ponvory Janssen Inc.

N/A 2021-04-28 2027-04-28 N/A 2029-04-28 propiverine hydrochloride 188323 Mictoryl / Mictoryl Pediatric Duchesnay Inc. N/A 2017-01-05 2023-01-05 Yes 2025-07-05 radium - 223 dichloride 161312 Xofigo Bayer Inc. N/A 2013-12-12 2019-12-12 N/A 2021-12-12 ramucirumab 176810 Cyramza Eli Lilly Canada Inc. N/A 2015-07-16 2021-07-16 N/A 2023-07-16 ravulizumab 217955 Ultomiris Alexion Pharma GmbH N/A 2019-08-28 2025-08-28 N/A 2027-08-28 recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) 235672 Supemtek Sanofi Pasteur Limited N/A 2021-01-14 2027-01-14 N/A 2029-01-14 recombinant human papillomaseroquel types 31, 33, 45, 52 and 58 170006 Gardasil 9 Merck Canada Inc. N/A 2015-02-05 2021-02-05 Yes 2023-08-05 recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) 147275 Bexsero GlaxoSmithKline Inc.

N/A 2013-12-06 2019-12-06 Yes 2022-06-06 recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) 177290 Obizur Takeda Canada Inc. N/A 2015-10-14 2021-10-14 N/A 2023-10-14 regorafenib monohydrate 157970 Stivarga Bayer Inc. N/A 2013-03-11 2019-03-11 Yes 2021-09-11 remdesivir 240551 Veklury Gilead Sciences Canada, Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 reslizumab 185873 Cinqair Teva Canada Limited N/A 2016-07-20 2022-07-20 Yes 2025-01-20 ribociclib (supplied as ribociclib succinate) 203884 Kisqali Novartis Pharmaceuticals Canada Inc. N/A 2018-03-02 2024-03-02 N/A 2026-03-02 rifaximin 161256 Zaxine Salix Pharmaceuticals Inc.

N/A 2013-08-13 2019-08-13 N/A 2021-08-13 riociguat 162761 Adempas Bayer Inc. N/A 2013-09-19 2019-09-19 N/A 2021-09-19 ripretinib 234688 Qinlock Deciphera Pharmaceuticals, LLC N/A 2020-06-19 2026-06-19 N/A 2028-06-19 risankizumab 215753 Skyrizi AbbVie Corporation N/A 2019-04-17 2025-04-17 N/A 2027-04-17 risdiplam 242373 Evrysdi Hoffman-La Roche Limited N/A 2021-04-14 2027-04-14 Yes 2029-10-14 romidepsin 152293 Istodax Celgene Inc. N/A 2013-10-16 2019-10-16 N/A 2021-10-16 romosozumab 197713 Evenity Amgen Canada Inc. N/A 2019-06-17 2025-06-17 N/A 2027-06-17 rupatadine (supplied as rupatadine fumarate) 186488 Rupall Medexus Pharmaceuticals Inc. N/A 2016-07-20 2022-07-20 Yes 2025-01-20 sacubitril 182734 Entresto Novartis Pharmaceuticals Canada Inc.

N/A 2015-10-02 2021-10-02 N/A 2023-10-02 safinamide (as safinamide mesylate) 207115 Onstryv Valeo Pharma Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 sarilumab 191745 Kevzara Sanofi-aventis Canada Inc. N/A 2017-01-12 2023-01-12 N/A 2025-01-12 satralizumab 233642 Enspryng Hoffmann-La Roche Limited N/A 2020-06-01 2026-06-01 Yes 2028-12-01 sebelipase alfa 204085 Kanuma Alexion Pharma GmbH N/A 2017-12-15 2023-12-15 Yes 2026-06-15 secukinumab 170732 Cosentyx Novartis Pharmaceuticals Canada Inc. N/A 2015-02-27 2021-02-27 Yes 2023-08-27 selexipag 182114 Uptravi Janssen Inc. N/A 2016-01-20 2022-01-20 N/A 2024-01-20 selpercatinib 243748 Retevmo Loxo Oncology Inc.

N/A 2021-06-15 2027-06-15 Yes 2029-12-15 semaglutide 202059 Ozempic Novo Nordisk Canada Inc. Rybelsus 2018-01-04 2024-01-04 N/A 2026-01-04 siltuximab 174291 Sylvant EUSA Pharma (UK) Limited N/A 2014-12-03 2020-12-03 N/A 2022-12-03 simeprevir 164021 Galexos Janssen Inc. N/A 2013-11-18 2019-11-18 N/A 2021-11-18 siponimod 223225 Mayzent Novartis Pharmaceuticals Canada Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 sodium zirconium cyclosilicate 218799 Lokelma AstraZeneca Canada Inc. N/A 2019-07-25 2025-07-25 N/A 2027-07-25 sofosbuvir 165043 Sovaldi Gilead Sciences Canada Inc.

HarvoniEpclusaVosevi 2013-12-13 2019-12-13 N/A 2021-12-13 solriamfetol hydrochloride 237511 Sunosi Jazz Pharmaceuticals Ireland Ltd. N/A 2021-05-13 2027-05-13 N/A 2029-11-13 sonidegib phosphate 229407 Odomzo Sun Pharma Global FZE N/A 2020-06-12 2026-06-12 N/A 2028-06-12 sucroferric oxyhydroxide 201492 Velphoro Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-01-05 2024-01-05 N/A 2026-01-05 sugammadex sodium 180385 Bridion Merck Canada Inc. N/A 2016-02-05 2022-02-05 N/A 2024-02-05 suvorexant 196367 Belsomra Merck Canada Inc. N/A 2018-11-29 2024-11-29 N/A 2026-11-29 tafamidis meglumine 228368 Vyndaqel Pfizer Canada ULC Vyndamax 2020-01-20 2026-01-20 N/A 2028-01-20 tafluprost 165596 Saflutan Purdue Pharma N/A 2014-05-26 2020-05-26 N/A 2022-05-26 talazoparib (supplied as talazoparib tosylate) 220584 Talzenna Pfizer Canada ULC N/A 2019-09-06 2025-09-06 N/A 2027-09-06 taliglucerase alfa 140854 Elelyso Pfizer Canada Inc.

N/A 2014-05-29 2020-05-29 Yes 2022-11-29 tedizolid phosphate 173603 Sivextro Merck Canada Inc. N/A 2015-03-17 2021-03-17 N/A 2023-03-17 teduglutide 180223 Revestive Takeda Canada Inc. N/A 2015-09-04 2021-09-04 Yes 2024-03-04 telotristat ethyl (as telotristat etiprate) 208730 Xermelo Ipsen Biopharmaceuticals Canada Inc. N/A 2018-10-10 2024-10-10 N/A 2026-10-10 tenapanor hydrochloride 224850 Ibsrela Knight Therapeutics Inc. N/A 2020-04-15 2026-04-15 N/A 2028-04-15 tenofovir alafenamide hemifumarate 181399 Genvoya Gilead Sciences Canada Inc.

DescovyOdefseyVemlidySymtuzaBiktarvy 2015-11-27 2021-11-27 Yes 2024-05-27 tepotinib (supplied as tepotinib hydrochloride) 242300 Tepmetko EMD Serono, a Division of EMD Inc., Canada N/A 2021-05-27 2027-05-27 N/A 2029-05-27 teriflunomide 160646 Aubagio Genzyme Canada a division of Sanofi-aventis Canada Inc. N/A 2013-11-14 2019-11-14 Yes 2022-05-14 tesamorelin 131836 Egrifta Theratechnologies Inc. N/A 2014-04-29 2020-04-29 N/A 2022-04-29 tezacaftor 211292 Symdeko Vertex Pharmaceuticals (Canada) Incorporated N/A 2018-06-27 2024-06-27 Yes 2026-12-27 tildrakizumab 224036 Ilumya Sun Pharma Global FZE N/A 2021-05-19 2027-05-19 N/A 2029-05-19 tisagenlecleucel 213547 / 213698 Kymriah Novartis Pharmaceuticals Canada Inc. N/A 2018-09-05 2024-09-05 Yes 2027-03-05 tofacitinib 154642 Xeljanz Pfizer Canada Inc. N/A 2014-04-17 2020-04-17 Yes 2022-10-17 trametinib 157665 Mekinist Novartis Pharmaceuticals Canada Inc.

N/A 2013-07-18 2019-07-18 N/A 2021-07-18 trastuzumab deruxtecan 242104 Enhertu AstraZeneca Canada Inc. N/A 2021-04-15 2027-04-15 N/A 2029-04-15 trastuzumab emtansine 162414 Kadcyla Hoffmann-La Roche Limited N/A 2013-09-11 2019-09-11 N/A 2021-09-11 trifarotene 221945 Aklief Galderma Canada Inc. N/A 2019-11-25 2025-11-25 Yes 2028-05-25 tipiracil hydrochloride 205852 Lonsurf Taiho Pharma Canada Inc. N/A 2018-01-25 2024-01-25 N/A 2026-01-25 triheptanoin 242196 Dojolvi Uagenyx Pharmaceutical Inc. N/A 2021-02-15 2027-02-15 Yes 2029-08-15 tucatinib 235295 Tukysa Seagen Inc.

N/A 2020-06-05 2026-06-05 N/A 2028-06-05 turoctocog alfa 170796 Zonovate Novo Nordisk Canada Inc. N/A 2014-12-08 2020-12-08 Yes 2023-06-08 umeclidinium bromide 161585 Anoro Ellipta GlaxoSmithKline Inc. Incruse Ellipta 2013-12-23 2019-12-23 N/A 2021-12-23 upadacitinib 223734 Rinvoq AbbVie Corporation N/A 2019-12-23 2025-12-23 N/A 2027-12-23 varicella-zoster seroquel glycoprotein E (gE) 200244 Shingrix GlaxoSmithKline Inc. N/A 2017-10-13 2023-10-13 N/A 2025-10-13 vedolizumab 169414 Entyvio Takeda Canada Inc. N/A 2015-01-29 2021-01-29 Yes 2023-07-29 velpatasvir 190521 Epclusa Gilead Sciences Canada Inc.

Vosevi 2016-07-11 2022-07-11 Yes 2025-01-11 venetoclax 190761 Venclexta AbbVie Corporation N/A 2016-09-30 2022-09-30 N/A 2024-09-30 vernakalant hydrochloride 190817 Brinavess Cipher Pharmaceuticals Inc. N/A 2017-03-13 2023-03-13 N/A 2025-03-13 vilanterol trifenatate 157301 Breo Ellipta GlaxoSmithKline Inc. Anoro ElliptaTrelegy Ellipta 2013-07-03 2019-07-03 Yes 2022-01-03 vilazodone hydrochloride 176820 Viibryd Allergan Inc. N/A 2015-07-16 2021-07-16 Yes 2024-01-16 von willebrand factor (recombinant) (vonicog alfa) 213188 Vonvendi Takeda Canada Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 vorapaxar sulfate 179320 Zontivity Toprol Acquisition LLC N/A 2016-05-13 2022-05-13 N/A 2024-05-13 voretigene neparvovec 233097 Luxturna Novartis Pharmaceuticals Canada Inc.

N/A 2020-10-13 2026-10-13 Yes 2029-04-13 vortioxetine hydrobromide 159019 Trintellix Lundbeck Canada Inc. N/A 2014-10-22 2020-10-22 Yes 2023-04-22 voxilaprevir 202324 Vosevi Gilead Sciences Canada Inc. N/A 2017-08-16 2023-08-16 N/A 2025-08-16 zanubrutinib 242748 Brukinsa BeiGene Switzerland GmbH N/A 2021-03-01 2027-03-01 N/A 2029-03-01On this page June 2021Product Monograph Brand Safety Updates June 2021(PDF, 101 KB, 4 pages) June 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Administration Overdosage Consumer Information Altace HCT 246597 Hydrochlorothiazide, Ramipril Bausch Health, Canada Inc No Yes No Yes No No No Yes Aspirin 81 mg, Aspirin 81 mg Quick Chews, Aspirin Regular Strength, Aspirin Extra Strength 248124 Acetylsalicylic Acid Bayer Inc No Yes No Yes Yes No No No Bricanyl Turbuhaler 239089 Terbutaline Sulfate AstraZeneca Canada Inc Yes Yes No No No No No Yes Cellcept, Cellcept I.V. 248429 Mycophenolate Mofetil Hoffmann-La Roche Limited No Yes No No No No No Yes Cipro XL 248371 Ciprofloxacin Hydrochloride Bayer Inc Yes No No No No Yes No Yes Cipro, Cipro Oral Suspension 248370 Ciprofloxacin Hydrochloride Bayer Inc Yes No No No No Yes No Yes Clozaril 247538 Clozapine HLS Therapeutics Inc No Yes Yes No No Yes No Yes Combogesic 248697 Ibuprofen, Acetaminophen Biosyent Pharma Inc No No No Yes No Yes No No Efudex 246337 Fluorouracil Bausch Health, Canada Inc Yes Yes Yes Yes Yes Yes Yes Yes Epclusa 247195 Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Erleada 241210 Apalutamide Janssen Inc No Yes No Yes No Yes No Yes Harvoni 247194 Ledipasvir, Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Hemangiol 247151 Propranolol Hcl Pierre Fabre Dermo-Cosmetique Canada Inc No Yes No Yes No No No Yes Idamycin PFS 249085 Idarubicin Hcl Pfizer Canada ULC No No No Yes No No No Yes Imbruvica 248172 Ibrutinib Janssen Inc No Yes No Yes No No No Yes Inderal-LA 248972 Propranolol Hcl Pfizer Canada ULC No No No Yes No No No Yes Jakavi 247787 Ruxolitinib Phosphate Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Lorbrena 247174 Lorlatinib Pfizer Canada ULC No Yes No Yes No Yes No Yes Lynparza 249369 Olaparib AstraZeneca Canada Inc No No No Yes No No No Yes Manerix 246047 Moclobemide Bausch Health, Canada Inc Yes Yes No Yes Yes Yes Yes Yes Maxidol Liquid Gels 248432 Naproxen Sodium Bayer Inc No No No Yes No No No Yes Nerlynx 242449 Neratinib Maleate Knight Therapeutics Inc No Yes No Yes Yes Yes No Yes Ofev 241747 Nintedanib Boehringer Ingelheim (Canada) Ltd Ltee No Yes No No Yes No No Yes Orgalutran 248614 Ganirelix Acetate Organon Canada Inc Yes Yes No Yes No Yes No Yes Pat-Galantamine ER 248978 Galantamine Hydrobromide Janssen Inc No Yes No Yes No Yes No Yes Piqray 248616 Alpelisib Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Ralivia 246159 Tramadol Hcl Bausch Health, Canada Inc No Yes No Yes No No Yes Yes Retrovir (AZT) 249459 Zidovudine ViiV Healthcare ULC No Yes Yes No Yes Yes Yes Yes Rinvoq 241253 Upadacitinib Abbvie Corporation No Yes No Yes No Yes No Yes Rivotril 245341 Clonazepam Hoffmann-La Roche Limited No Yes Yes Yes Yes Yes No Yes Rydapt 247829 Midostaurin Novartis Pharmaceuticals Canada Inc No No No Yes No No No Yes Sandoz Zopiclone Tablet 247527 Zopiclone Sandoz Canada Incorporated No Yes Yes Yes No Yes No Yes Sovaldi 247196 Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Synalar 247002 Fluocinolone Acetonide Bausch Health, Canada Inc No Yes No Yes No No No Yes Tapazole 246350 Methimazole Paladin Labs Inc No Yes No No No No Yes Yes Toviaz 248542 Fesoterodine Fumarate Pfizer Canada ULC Yes Yes No Yes Yes Yes No No Trileptal 247670 Oxcarbazepine Novartis Pharmaceuticals Canada Inc No Yes No No No Yes No Yes Valium 245343 Diazepam Hoffmann-La Roche Limited No Yes Yes Yes Yes Yes No Yes Vaseretic 247516 Enalapril Maleate, Hydrochlorothiazide Organon Canada Inc No Yes No No Yes No No Yes Vasotec 247519 Enalapril Maleate Organon Canada Inc No Yes No No Yes No No Yes Wellbutrin XL 247849 Bupropion Hcl Bausch Health, Canada Inc Yes Yes No Yes Yes Yes Yes Yes Zyban 247564 Bupropion Hcl Bausch Health, Canada Inc Yes Yes No Yes Yes Yes Yes Yes Zyvoxam 248930 Linezolid Pfizer Canada ULC No Yes No Yes No Yes No Yes May 2021Product Monograph Brand Safety Updates May 2021(PDF, 90 KB, 2 pages) May 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Afinitor, Afinitor Disperz 247570 Everolimus Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Androcur, Androcur Depot 245903 Cyproterone Acetate Bayer Inc No Yes No Yes No No No Yes Apo-Clobazam 245505 Clobazam Apotex Inc No Yes Yes Yes Yes Yes No Yes Ativan 245317 Lorazepam Pfizer Canada ULC No Yes Yes Yes Yes Yes No Yes Aubagio 247354 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No No No Yes No No No Yes Biktarvy 240953 Emtricitabine, Bictegravir Sodium, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc No Yes No Yes No Yes No Yes Ceftriaxone Sodium for Injection 246728 Ceftriaxone Sodium Teva Canada Limited No No No Yes No No No Yes Depakene 247699 Valproic Acid BGP Pharma ULC No Yes No Yes No No No Yes Diastat 245322 Diazepam Valeant Pharmaceuticals North America Llc No Yes Yes Yes Yes Yes No Yes Diazepam Injection USP 245324 Diazepam Sandoz Canada Incorporated Yes Yes Yes Yes Yes Yes No Yes Epival 247581 Divalproex Sodium BGP Pharma ULC No Yes No Yes No No No Yes Eucrisa 240171 Crisaborole Pfizer Canada ULC No No No No Yes No No Yes Lorazepam Injection USP 245339 Lorazepam Sandoz Canada Incorporated No Yes Yes Yes Yes Yes No Yes Mayzent 245078 Siponimod Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Ofev 247352 Nintedanib Boehringer Ingelheim (Canada) Ltd Ltee No Yes No Yes Yes Yes Yes Yes Prinivil 247696 Lisinopril Merck Canada Inc No Yes No No Yes No No Yes Sevorane AF 246821 Sevoflurane Abbvie Corporation No Yes No Yes No No No Yes Soliqua 247226 Lixisenatide, Insulin Glargine Sanofi-Aventis Canada Inc No Yes No Yes No Yes No Yes Tegretol 247229 Carbamazepine Novartis Pharmaceuticals Canada Inc Yes Yes Yes Yes Yes Yes Yes Yes Toloxin 246803 Digoxin Pendopharm Division of Pharmascience Inc No No No No No Yes No Yes Topamax 247698 Topiramate Janssen Inc Yes Yes No No Yes Yes Yes Yes Trelegy Ellipta 240101 Umeclidinium Bromide, Fluticasone Furoate, Vilanterol Trifenatate GlaxoSmithKline Inc Yes Yes No Yes Yes Yes Yes Yes Vitrakvi 241249 Larotrectinib Sulfate Bayer Inc No Yes No Yes Yes Yes No No Vosevi 247191 Voxilaprevir, Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No No No Yes No No No Yes Xanax,Xanax TS 245344 Alprazolam Upjohn Canada ULC No Yes Yes Yes Yes Yes No Yes Xylocard 246218 Lidocaine Hcl Aspen Pharmacare Canada Inc.

Yes Yes No No No Yes Yes Yes April 2021Product Monograph Brand Safety Updates April 2021(PDF, 84.6 KB, 2 pages) April 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Avalide 246609 Hydrochlorothiazide, Irbesartan Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Avapro 246866 Irbesartan Sanofi-Aventis Canada Inc No No No Yes No No No Yes Docetaxel Injection USP 246984 Docetaxel Pfizer Canada ULC No Yes Yes Yes No No No Yes Duodopa 245733 Levodopa, Carbidopa Monohydrate AbbVie Corporation No Yes No No No Yes No Yes Hydromorphone Hydrochloride Injection USP 237401 Hydromorphone Hcl Sandoz Canada Incorporated No No No No No Yes Yes No Iressa 246584 Gefitinib AstraZeneca Canada Inc No No No Yes No No No Yes Kazano 243901 Metformin Hcl, Alogliptin Benzoate Takeda Canada Inc No No No Yes No No No Yes Naproxen Capsules200 Mg 245549 Naproxen Catalent Ontario Limited No Yes No Yes Yes No No Yes Nesina 243900 Alogliptin Benzoate Takeda Canada Inc No Yes No Yes No No No Yes Nexplanon 247049 Etonogestrel Organon Canada Inc. No Yes No No No No No Yes Opsumit 246750 Macitentan Janssen Inc No No No No Yes No No Yes Reactine Fast Melt Junior 246339 Cetirizine Hydrochloride McNeil Consumer Healthcare Division of Johnson &.

Johnson Inc No No No No No No No Yes Sandostatin, Sandostatin LAR 247160 Octreotide Novartis Pharmaceuticals Canada Inc No No No Yes No No Yes No Seroquel, Seroquel XR >246849 Quetiapine Fumarate AstraZeneca Canada Inc No Yes Yes Yes Yes Yes No Yes Sinemet 246915 Carbidopa Monohydrate, Levodopa Organon Canada Inc. No No No No No Yes No Yes Vosevi >245142 Voxilaprevir, Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No Yes No Yes No No No Yes Xeloda 247293 Capecitabine Hoffmann La Roche Limited No No No Yes No No No Yes Zenhale 239493 Formoterol Fumarate Dihydrate, Mometasone Furoate Organon Canada Inc. No Yes No Yes No Yes No Yes March 2021Product Monograph Brand Safety Updates March 2021(PDF, 108 KB, 3 pages) March 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Administration Overdosage Consumer Information Abilify Maintena 237149 Aripiprazole Otsuka Pharmaceutical Co Ltd No Yes No No No Yes No Yes Accuretic 244863 Hydrochlorothiazide, Quinapril Hcl Pfizer Canada ULC No Yes No Yes No No No Yes Aldactazide 25, Aldactazide 50 244911 Hydrochlorothiazide, Spironolactone Pfizer Canada ULC No Yes No Yes No No No Yes Alunbrig 237680 Brigatinib Takeda Canada Inc No Yes No Yes No No No Yes Asacol 245536 Mesalazine Allergan Inc No Yes No Yes Yes No No Yes Asacol 800 245722 Mesalazine Allergan Inc No Yes No Yes Yes No No Yes Balversa 245919 Erdafitinib Janssen Inc No No No No Yes No No No Belsomra 244781 Suvorexant Merck Canada Inc No Yes No Yes No No No Yes Buscopan 245198 Hyoscine Butylbromide Sanofi Consumer Health Inc Yes Yes No No No No Yes Yes Cellcept 245034 Mycophenolate Mofetil Hydrochloride, Mycophenolate Mofetil Hoffmann La Roche Limited No No No Yes No No No Yes Children's Advil 244560 Ibuprofen GlaxoSmithkKine Consumer Healthcare ULC No Yes No No No Yes No Yes Cymbalta 245810 Duloxetine Hcl Eli Lilly Canada Inc No Yes No No No No No Yes Flovent HFA, Flovent Diskus 243742 Fluticasone Propionate GlaxoSmithkKine Inc No Yes No Yes No Yes Yes Yes Gemcitabine Injection 245820 Gemcitabine Hcl Pfizer Canada ULC No Yes No Yes No No No No Glatect 244549 Glatiramer Acetate Pharmascience Inc No Yes No Yes No No No Yes Glyxambi 243907 Linagliptin, Empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee No No No Yes No No No Yes Imbruvica 238064 Ibrutinib Janssen Inc No Yes No Yes Yes No No Yes Invanz 245199 Ertapenem Sodium Merck Canada Inc No No No Yes No No No Yes Jentadueto 243906 Metformin Hcl, Linagliptin Boehringer Ingelheim (Canada) Ltd Ltee No No No Yes No No No Yes Jorveza 238101 Budesonide Avir Pharma Inc No No No Yes No Yes No Yes Lynparza 246316 Olaparib AstraZeneca Canada Inc No Yes No Yes No No No Yes Maviret 245141 Pibrentasvir, Glecaprevir Abbvie Corporation Yes Yes No Yes No No No Yes Mekinist 245843 Trametinib Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Motrin Liquid Gels 200 Mg, Motrin Liquid Gels 400 Mg 244305 Ibuprofen McNeil Consumer Healthcare Division of Johnson &. Johnson Inc No Yes No No No No No Yes Neupro 245289 Rotigotine UCB Canada Inc No Yes No Yes No No No Yes Nolvadex-D 243317 Tamoxifen Citrate AstraZeneca Canada Inc Yes Yes No Yes Yes No No No Octostim 244562 Desmopressin Acetate Ferring Inc Yes Yes No Yes Yes Yes Yes Yes Onbrez Breezhaler 245077 Indacaterol Maleate Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes No No Yes Onpattro 245256 Patisiran Sodium Alnylam Netherlands B.V. No Yes No Yes No No No Yes PMS-Methadone 241778 Methadone Hydrochloride Paladin Labs Inc Yes Yes Yes Yes Yes Yes Yes Yes Prevacid, Prevacid Fastab 241989 Lansoprazole Takeda Pharmaceuticals America Inc No Yes No Yes No No No No Radicava 245593 Edaravone Mitsubishi Tanabe Pharma Corporation No No No No No Yes No No Sandoz Methylphenidate SR 244991 Methylphenidate Hcl Sandoz Canada Incorporated No Yes No Yes No Yes No Yes Sandoz Perindopril Erbumine/Indapamide LD, Sandoz Perindopril Erbumine/Indapamide, Sandoz Perindopril Erbumine/Indapamide HD 244537 Indapamide, Perindopril Erbumine Sandoz Canada Incorporated Yes Yes No Yes Yes No No Yes Septra Injection 245929 Trimethoprim, Sulfamethoxazole Aspen Pharmacare Canada Inc. No Yes Yes Yes No No No Yes Serevent Diskus 243734 Salmeterol Xinafoate GlaxoSmithKline Inc Yes Yes No Yes Yes Yes No Yes Solu-Medrol, Solu-Medrol Act-O-Vials 245362 Methylprednisolone Pfizer Canada ULC No Yes No No No No No No Somatuline Autogel 245315 Lanreotide Ipsen Biopharmaceuticals Canada Inc Yes Yes Yes Yes Yes Yes No Yes Tafinlar 245834 Dabrafenib Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Thalomid 244994 Thalidomide Celgene Inc No Yes No Yes No No No Yes Trintellix 237793 Vortioxetine Hydrobromide Lundbeck Canada Inc No Yes No Yes No No No Yes Viibryd 237588 Vilazodone Hydrochloride Allergan Inc No Yes No Yes No Yes No No Vocabria, Cabenuva 238803 Rilpivirine, Cabotegravir ViiV Healthcare ULC Yes Yes No Yes Yes Yes No Yes Zepatier 245140 Grazoprevir, Elbasvir Merck Canada Inc No Yes No Yes No No No Yes February 2021Product Monograph Brand Safety Updates February 2021(PDF, 83 KB, 2 pages) February 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &.

Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Abilify 242200 Aripiprazole Otsuka Pharmaceutical Co Ltd No Yes No Yes No No No Yes Aleve Caplets 243112 Naproxen Sodium Bayer Inc No No No No No Yes No Yes Aubagio 243821 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Belkyra 242465 Deoxycholic Acid Kythera Biopharmaceuticals Inc No Yes No Yes No No No Yes Biktarvy 237235 Emtricitabine, Bictegravir Sodium, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc No No No Yes No No No Yes Bridion 237151 Sugammadex Merck Canada Inc No Yes No Yes No No No No Clobex Spray 244309 Clobetasol Propionate Galderma Canada Inc Yes Yes No Yes No Yes Yes Yes Definity 242706 Perflutren Lantheus MI Canada Inc No Yes No No No No No No Depo-Medrol 245381 Methylprednisolone Acetate Pfizer Canada ULC No No No No No Yes No No Diflucan One 244031 Fluconazole Pfizer Canada ULC No No No No Yes No No Yes Metadol 241772 Methadone Hydrochloride Paladin Labs Inc No Yes No Yes Yes Yes No Yes Metadol-D 241773 Methadone Hydrochloride Paladin Labs Inc No Yes No Yes Yes Yes No Yes Mycobutin 244143 Rifabutin Pfizer Canada ULC No Yes No Yes No No No Yes Myleran 243043 Busulfan Aspen Pharmacare Canada Inc. No Yes No Yes No No No Yes Ninlaro 244191 Ixazomib Citrate Takeda Canada Inc No No No No No No Yes Yes Pomalyst 243491 Pomalidomide Celgene Inc No Yes Yes Yes Yes Yes Yes Yes Revatio 237407 Sildenafil Citrate Upjohn Canada ULC No No No Yes No No No No Sabril 244467 Vigabatrin Lundbeck Pharmaceuticals LLC No Yes No No No Yes No No Salofalk 242059 Mesalazine Aptalis Pharma Canada ULC No Yes No Yes Yes Yes No Yes Salofalk 242468 Mesalazine Aptalis Pharma Canada ULC No Yes No Yes Yes No No Yes Salofalk 242774 Mesalazine Aptalis Pharma Canada ULC No Yes No Yes Yes No No Yes Seasonale 245618 Levonorgestrel, Ethinyl Estradiol Teva Canada Limited Yes Yes Yes No No No No Yes Seasonique 245619 Levonorgestrel, Ethinyl Estradiol Teva Canada Limited Yes Yes Yes No No No No Yes Stieva-A 244142 Tretinoin GlaxoSmithKline Inc No Yes No No No Yes No Yes Symbicort Turbuhaler 244507 Formoterol Fumarate Dihydrate, Budesonide AstraZeneca Canada Inc No Yes No Yes Yes Yes Yes Yes Teveten Plus 244660 Hydrochlorothiazide, Eprosartan Mesylate BGP Pharma ULC No Yes No Yes No No No Yes Trajenta 243905 Linagliptin Boehringer Ingelheim (Canada) Ltd Ltee No No No Yes No No No Yes Trintellix 243819 Vortioxetine Hydrobromide Lundbeck Canada Inc No Yes No Yes Yes No No Yes Vfend 243931 Voriconazole Pfizer Canada ULC Yes No No No Yes No No Yes January 2021Product Monograph Brand Safety Updates January 2021(PDF, 83 KB, 2 pages) January 2021 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Administration Overdosage Consumer Information Addyi 229727 Flibanserin Searchlight Pharma Inc Yes Yes Yes Yes Yes Yes No Yes Aptivus 242983 Tipranavir Boehringer Ingelheim (Canada) Ltd Ltee No No No No Yes Yes No Yes Entocort Enema 242607 Budesonide Tillotts Pharma GmbH Yes Yes No No Yes Yes Yes Yes Fycompa 235549 Perampanel Eisai Limited No Yes No No Yes No No No Kyleena 243730 Levonorgestrel Bayer Inc No Yes No No No Yes No Yes Kyprolis 237196 Carfilzomib Amgen Canada Inc No Yes No Yes No Yes No Yes Micardis Plus 242123 Telmisartan, Hydrochlorothiazide Boehringer Ingelheim (Canada) Ltd Ltee Yes No No Yes Yes No No No Monistat Derm Cream 242581 Miconazole Nitrate Insight Pharmaceuticals LLC No Yes Yes No No No Yes Yes Omnipaque 180, Omnipaque 240, Omnipaque 300, Omnipaque 350 242219 Iohexol GE Healthcare Canada Inc No No No No No Yes No Yes Retin-A 235656 Tretinoin Bausch Health, Canada Inc. Yes Yes No Yes No Yes No Yes Rozlytrek 242028 Entrectinib Hoffmann La Roche Limited No No No Yes No Yes No Yes Sinemet 240018 Carbidopa, Levodopa Merck Canada Inc No No No No No Yes No No Tagrisso 243288 Osimertinib Mesylate AstraZeneca Canada Inc No Yes No Yes No Yes No Yes Tivicay 235583 Dolutegravir Sodium ViiV Healthcare ULC No Yes No Yes Yes Yes No Yes Trelstar 239594 Triptorelin Pamoate Knight Therapeutics Inc. No No No No No No No Yes Venclexta 243474 Venetoclax Abbvie Corporation No Yes No No No Yes No Yes Xarelto 234756 Rivaroxaban Bayer Inc Yes Yes No Yes Yes Yes Yes Yes Xylac 243159 Loxapine Succinate Pendopharm Division of Pharmascience Inc No Yes Yes Yes Yes Yes No Yes Ziagen 243476 Abacavir Sulfate ViiV Healthcare ULC No No No No Yes No No Yes Zytiga 244273 Abiraterone Acetate Janssen Inc No Yes No Yes No No No Yes December 2020Product Monograph Brand Safety Updates December 2020(PDF, 103 KB, 3 pages) December 2020 Brand Name Submission Number Ingredient(S) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Administration Overdosage Consumer Information Abilify Maintena 242346 Aripiprazole Otsuka Pharmaceutical Co Ltd No Yes No Yes No No No No Accel-Sevelamer 239213 Sevelamer Carbonate Accel Pharma Inc No Yes No No No Yes Yes Yes Adderall XR 241496 Amphetamine Aspartate, Dextroamphetamine Saccharate, Amphetamine Sulfate, Dextroamphetamine Sulfate Takeda Canada Inc No Yes No No Yes No No Yes Advagraf 241431 Tacrolimus Astellas Pharma Canada Inc No No No No Yes No No Yes Asmanex Twisthaler 241482 Mometasone Furoate Merck Canada Inc No Yes No No No Yes Yes Yes Biktarvy 242750 Emtricitabine, Bictegravir Sodium, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc No No No Yes No No No Yes Caduet 241827 Atorvastatin Calcium, Amlodipine Besylate Upjohn Canada ULC Yes Yes No No Yes No No Yes Caripul 241742 Epoprostenol Sodium Janssen Inc No Yes No No No No No Yes Dexilant 241999 Dexlansoprazole Takeda Canada Inc No Yes No Yes No No No No Duotrav PQ 242431 Travoprost, Timolol Maleate Novartis Pharmaceuticals Canada Inc No No No Yes No No No Yes Erythrocin I.V. 241362 Erythromycin Lactobionate Amdipharm Limited Yes Yes Yes Yes Yes No No Yes Gilenya 242144 Fingolimod Hydrochloride Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes Yes No Yes Idhifa 242218 Enasidenib Mesylate Celgene Inc No No No No Yes No No No Imbruvica 235706 Ibrutinib Janssen Inc No Yes No Yes No Yes No Yes Invanz 238455 Ertapenem Sodium Merck Canada Inc No Yes No No No No No Yes Invega 241812 Paliperidone Janssen Inc No Yes No Yes No No No Yes Invega Sustenna 241862 Paliperidone Palmitate Janssen Inc No Yes No Yes No No No Yes Invega Trinza 241830 Paliperidone Palmitate Janssen Inc No Yes No Yes No No No Yes Keppra 242697 Levetiracetam UCB Canada Inc No Yes No Yes No No No Yes Kisqali 237555 Ribociclib Succinate Novartis Pharmaceuticals Canada Inc No No No Yes No No No No Lenvima 242453 Lenvatinib Mesylate Eisai Limited No Yes No Yes Yes Yes No Yes Lipitor 241951 Atorvastatin Calcium Upjohn Canada ULC Yes Yes No No Yes No No Yes Luvox 238347 Fluvoxamine Maleate BGP Pharma ULC No Yes No No No No No No Mavenclad 238626 Cladribine EMD Serono a Division of EMD Inc Canada Yes Yes No No No No No Yes Moviprep 238575 Polyethylene Glycol 3350, Sodium Chloride, Potassium Chloride, Ascorbic Acid, Sodium Ascorbate, Sodium Sulfate Anhydrous Aralez Pharmaceuticals Canada Inc No Yes No No No No No Yes Olmetec 241065 Olmesartan Medoxomil Merck Canada Inc Yes Yes No Yes Yes No No Yes Olmetec Plus 241145 Hydrochlorothiazide, Olmesartan Medoxomil Merck Canada Inc Yes Yes No No Yes No Yes Yes Onivyde 243509 Irinotecan Sucrose Octasulfate Servier Canada Inc No Yes No No No No No Yes Onstryv 242236 Safinamide Valeo Pharma Inc No No No Yes No No No Yes Pantoloc 242003 Pantoprazole Takeda Canada Inc No Yes No Yes No No No No Pediapred 243283 Prednisolone Sodium Phosphate Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Prograf 241489 Tacrolimus Astellas Pharma Canada Inc No No No No Yes Yes No Yes Prolensa 238790 Bromfenac Sodium Sesquihydrate Bausch &. Lomb Inc No Yes No Yes No No No Yes Remeron 242352 Mirtazapine Merck Canada Inc No Yes No Yes No No No Yes Remeron RD 242354 Mirtazapine Merck Canada Inc No Yes No Yes No No No Yes Rexulti 242419 Brexpiprazole Otsuka Pharmaceutical Co Ltd No Yes No Yes No No No Yes Rifadin 241843 Rifampin Sanofi-Aventis Canada Inc No No No No Yes No No Yes Risperdal 241861 Risperidone Janssen Inc No Yes No Yes No No No Yes Risperdal Consta 241839 Risperidone Janssen Inc No Yes No Yes No No No Yes Stribild 238174 Emtricitabine, Tenofovir Disoproxil Fumarate, Cobicistat, Elvitegravir Gilead Sciences Canada Inc Yes No No No No No No Yes Tecta 242002 Pantoprazole Magnesium Takeda Canada Inc No Yes No Yes No No No No Teva-Loperamide 240985 Loperamide Hcl Teva Canada Limited No Yes No No No No Yes Yes Uam 241841 Tramadol Hcl Janssen Inc No Yes No Yes No No No Yes November 2020Product Monograph Brand Safety Updates November 2020(PDF, 91 KB, 2 pages) November 2020 Brand Name Submission Number Ingredient(S) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &. Precautions Adverse Reactions Drug Interactions Dosage &.

Administration Overdosage Consumer Information Adlyxine 240740 Lixisenatide Sanofi-Aventis Canada Inc No No No No No Yes No Yes Advil Cold &. Sinus Convenience Pack 240564 Ibuprofen, Pseudoephedrine Hcl, Chlorpheniramine Maleate GlaxoSmithKline Consumer Healthcare Inc Yes Yes No No Yes No No Yes Advil Day/Night Convenience Pack 240575 Ibuprofen, Diphenhydramine Hcl GlaxoSmithKline Consumer Healthcare Inc Yes Yes No Yes Yes No Yes Yes Auro-Cefixime 239750 Cefixime Auro Pharma Inc No Yes No No No No No Yes Avalide 241361 Hydrochlorothiazide, Irbesartan Sanofi-Aventis Canada Inc No Yes No Yes Yes No No Yes Avapro 241360 Irbesartan Sanofi-Aventis Canada Inc No Yes No Yes Yes No No Yes Azarga 242484 Timolol Maleate, Brinzolamide Novartis Pharmaceuticals Canada Inc No Yes No Yes No No No Yes Carbaglu 227936 Carglumic Acid Recordati Rare Diseases No Yes No Yes Yes Yes Yes Yes Claritin Kids Rapid Dissolve 228699 Loratadine Bayer Inc No No No No No Yes No Yes Cold + Sinus Daytime Cold + Sinus Nighttime 239435 Ibuprofen, Pseudoephedrine Hcl Vita Health Products Inc Yes Yes Yes No Yes No No Yes Depakene 242654 Valproic Acid BGP Pharma ULC No Yes No No No No No Yes Descovy 234525 Emtricitabine, Tenofovir Alafenamide Gilead Sciences Canada Inc No Yes Yes Yes No Yes No Yes Epclusa 233923 Velpatasvir, Sofosbuvir Gilead Sciences Canada Inc No Yes No Yes No Yes No Yes Epival 242651 Divalproex Sodium BGP Pharma ULC No Yes No No No No No Yes Erleada 241921 Apalutamide Janssen Inc No No No Yes No No No Yes Genvoya 238172 Emtricitabine, Tenofovir Alafenamide Hemifumarate, Cobicistat, Elvitegravir Gilead Sciences Canada Inc Yes No No No Yes No No Yes Jakavi 241484 Ruxolitinib Phosphate Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes No No Yes Lolo 238799 Ethinyl Estradiol, Norethindrone Acetate Allergan Inc No No No No No Yes No Yes Lonsurf 235999 Tipiracil Hydrochloride, Trifluridine Taiho Pharma Canada, Inc. No Yes No Yes No Yes No Yes Lupron, Lupron Depot 241744 Leuprolide Acetate Abbvie Corporation Yes Yes Yes Yes Yes Yes Yes Yes Micro+6 Concentrate 237994 Manganese Sulfate, Chromic Chloride, Cupric Sulfate, Selenious Acid, Zinc Sulfate Heptahydrate, Sodium Iodide Sandoz Canada Incorporated No Yes No No No Yes Yes No Mirena 243721 Levonorgestrel Bayer Inc No Yes No No No Yes No Yes PMS-Fluticasone Propionate/Salmeterol DPI 242762 Fluticasone Propionate, Salmeterol Xinafoate Pharmascience Inc No No No No No No No Yes Ravicti 241398 Glycerol Phenylbutyrate Horizon Therapeutics Ireland DAC No No No No No No No Yes Rydapt 241284 Midostaurin Novartis Pharmaceuticals Canada Inc No Yes No No No Yes No No Sandostatin LAR, Sandostatin 240998 Octreotide, Octreotide Acetate Novartis Pharmaceuticals Canada Inc No Yes No Yes Yes Yes No Yes Sandoz Metoprolol SR 240568 Metoprolol Tartrate Sandoz Canada Incorporated No No No No Yes No No Yes Sofracort 240569 Dexamethasone Sodium Metasulphobenzoate, Gramicidin, Framycetin Sulfate Sanofi-Aventis Canada Inc Yes Yes No Yes Yes No Yes Yes Tagrisso 242157 Osimertinib Mesylate AstraZeneca Canada Inc No No No Yes No No No Yes Tasigna 242015 Nilotinib Hydrochloride Monohydrate Novartis Pharmaceuticals Canada Inc No No No Yes No No No Yes Tiazac XC 238542 Diltiazem Hcl Valeant Canada LP Valeant Canada S.E.C. Yes Yes No Yes No No Yes Yes Xarelto 233166 Rivaroxaban Bayer Inc No Yes No Yes No Yes No Yes Zytiga 241627 Abiraterone Acetate Janssen Inc No Yes No Yes Yes No No Yes October 2020Product Monograph Brand Safety Updates October 2020(PDF, 70KB, 1 page) October 2020 Brand Name Submission Number Ingredient(S) Manufacturer Contraindications Warnings &. Precautions Serious Warnings &.

Precautions Adverse Reactions Drug Interactions Dosage &. Administration Overdosage Consumer Information Aubagio 239626 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc No Yes No Yes Yes No No Yes Elmiron 239842 Pentosan Polysulfate Sodium Janssen Inc Yes Yes Yes Yes No No No Yes Ibuprofen Liquid Filled Capsules, Extra Strength Ibuprofen Liquid Filled Capsules 240415 Ibuprofen Apotex Inc Yes Yes No No Yes No No Yes Imovane 240565 Zopiclone Sanofi-Aventis Canada Inc Yes Yes Yes Yes Yes No No Yes Ketalar 238402 Ketamine Hydrochloride ERFA Canada 2012 Inc Yes Yes No Yes No Yes No No Kisqali 233623 Ribociclib Succinate Novartis Pharmaceuticals Canada Inc No Yes No Yes No Yes No No Maviret 234362 Pibrentasvir, Glecaprevir Abbvie Corporation No No No No No Yes No No Plavix 239831 Clopidogrel Bisulfate Sanofi-Aventis Canada Inc No Yes No No Yes No No Yes Prezcobix 240107 Darunavir Ethanolate, Cobicistat Janssen Inc No No No No Yes No No Yes Prezista 240039 Darunavir Ethanolate Janssen Inc No No No No Yes No No Yes Renagel 238457 Sevelamer Hydrochloride Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Renvela 238461 Sevelamer Carbonate Sanofi-Aventis Canada Inc No Yes No Yes No No No Yes Salazopyrin, Salazopyrin En-Tabs 239257 Sulfasalazine Pfizer Canada ULC No No No Yes No No No No Symtuza 240432 Darunavir Ethanolate, Emtricitabine, Cobicistat, Tenofovir Alafenamide Hemifumarate Janssen Inc No No No No Yes No No Yes Tagrisso 234607 Osimertinib Mesylate AstraZeneca Canada Inc No Yes No Yes No Yes No No Talzenna 234108 Talazoparib Pfizer Canada ULC No Yes No Yes Yes Yes No No Tenormin 239845 Atenolol AstraZeneca Canada Inc No Yes No No No No No No Teva-Mexiletine 238065 Mexiletine Hcl Teva Canada Limited No Yes No No No No No No Twynsta 239007 Telmisartan, Amlodipine Besylate Boehringer Ingelheim (Canada) Ltd Ltee Yes Yes No Yes Yes No Yes Yes Zejula 237670 Niraparib GlaxoSmithKline Inc No Yes No Yes Yes Yes No Yes Zerbaxa 238477 Ceftolozane Sulfate, Tazobactam Sodium Merck Canada Inc No Yes No No No No No Yes Zofran, Zofran ODT 240200 Ondansetron Hydrochloride Dihydrate Novartis Pharmaceuticals Canada Inc No Yes No No No No No Yes September 2020Product Monograph Brand Safety Updates September 2020(PDF, 72 KB, 1 page) September 2020 Brand Name Submission Number Ingredient(s) Manufacturer Contraindications Warnings &.

Seroquel advertisement

As antidepressant drugs cases soar and treatment seroquel advertisement rollout evolves, hospitals are also working to comply with a federal price transparency rule that took effect on Jan. 1.The American Hospital Association (AHA) has argued that the rule – which requires hospitals to seroquel advertisement post the prices insurers actually pay for services – will harm hospital negotiations with insurers, require vast resources to implement, and yield little benefit for consumers. But a federal appeals court in December ruled against the group's legal challenge, and now hospitals across the country are working to seroquel advertisement comply.

The Centers for Medicare and Medicaid Services (CMS) and staunch supporters of the rule say that it's a critical new step towards driving down out-of-control healthcare costs.The rule requires hospitals to post prices online for 300 shoppable services. Seventy of seroquel advertisement those are mandated by CMS. They range from new patient visits and kidney function lab tests to MRI scans of the brain, major joint replacement, and cardiothoracic seroquel advertisement procedures for patients with comorbidities.Prices must be provided in a machine-readable file and a display that's consumer-friendly.Hospitals' PerspectiveThe AHA said it supports the goal of increasing price transparency, but through improving access to out-of-pocket estimates that are more beneficial to consumers than privately negotiated prices.

It said that posting such prices can be confusing to patients and harm the marketplace."We worry about seroquel advertisement the anticompetitive actions that could be a fallout of these numbers," Ariel Levin, senior associate director for policy at the AHA, told MedPage Today.Levin also said that complying with the rule is a huge amount of work for hospitals that are simultaneously stretching their resources to the brink in the battle against antidepressant drugs.In an amicus brief filed in July, 40 state hospital associations detailed their support for the national group in its ultimately unsuccessful legal challenge to the rule. One Ohio hospital system stated that producing and updating the required data would cost as much as $2 million annually, and that the number of data points it would need to post exceeded 210 million. Other hospitals noted they would have to hire outside consultants at a seroquel advertisement cost of $100,000 or more to help with the process, and that resources for day-to-day operations were already tight."Those are time and financial resources that could be put to better use elsewhere," Levin said.

Some of the same staff now preparing hospitals for surge capacity and tracking treatment rollout – such as finance and information technology employees – are also working on complying with the price transparency rule, she said.Richard Miller, executive vice president and chief business strategy officer at Northwell Health in New York, said that complying with the rule's requirements does demand significant resources initially and on an ongoing basis."It certainly is a large undertaking," Miller said seroquel advertisement. "We have 19 hospitals in our system and a pretty extensive list of services that we offer."Northwell first put a price estimator tool on its website 10 years ago, he said. Since that time, patient surveys have indicated that out-of-pocket cost estimates continue to be of interest to consumers, especially with the rise of high-deductible plans.The health system's latest consumer-shoppable tool in compliance with the price transparency rule seroquel advertisement went live in December, Miller said.

The health system invested a few million dollars in it, he said, and the total investment in making the required machine-readable files is still being determined."While we have been working diligently seroquel advertisement to serve our communities through the seroquel's latest surge, including vaccinating our frontline caregivers, we also have been preparing for the new hospital price transparency requirements," a spokesman for Nashville-based HCA Healthcare said. "That includes posting machine-readable files containing the required rate and charge information and providing a patient payment estimator tool on the 'patients and visitors' and 'patient financial' sections of our hospital websites."A spokeswoman for RWJBarnabas Health in New Jersey said that the health system has established an online resource for members of the public, and that, in accordance with the new rule, it seroquel advertisement is continuing to update information contained within its website.Will Policy Drive Down Costs?. Caitlin Donovan, senior director of public relations at the National Patient Advocate Foundation, said that the organization supports the new rule as part of broader efforts to help address what patients pay for care.Healthcare costs in the U.S.

Are "wildly out of line," Donovan said.The rule is well-suited for consumers needing procedures seroquel advertisement such as X-rays and imaging, she said. That would involve seroquel advertisement looking at prices for one procedure at a few different in-network facilities.Navigating price postings may prove challenging for consumers in need of more complex services, Donovan said. Other potential challenges include that a patient may not be able to make a decision about where they receive care because of their medical condition, constraints by their insurer, or their focus on perceived value of care and convenience over cost.Patients may be taking more time with decisions about elective procedures during the seroquel, but they may be sicker when they do seek services, Donovan said, which could be a hindrance to using the price postings.Overall, the rule stands to make consumers more familiar with the concept of shopping around for services in advance, she said.

"People like us who have case managers who may be working to negotiate down bills, we may be able to use [the posted prices] on behalf of patients," she added.Though hospitals and other health professionals have questioned how often consumers will use the new price postings to shop for care, it's not only about the numbers, supporters of the rule hold.Marty Makary, MD, MPH, of Johns Hopkins University in Baltimore and editor-in-chief of MedPage Today, said that the argument that people don't use pricing information when determining where seroquel advertisement to seek services isn't focusing on the right question. Proxy shoppers, including employers and consumers who may pay out-of-pocket for care, can seroquel advertisement drive the marketplace, he said.Makary pointed to the example of two hospitals in the same area that provide the same quality of care charging drastically different prices for delivering a baby."Billing quality is medical quality. Financial toxicity seroquel advertisement is a medical complication," he said.

"Taking care of a patient means taking care of the whole person."CMS said it expects the rule to help to increase market competition and ultimately drive down the cost of healthcare services for patients.Now that the rule has taken effect, CMS is auditing a sample of hospitals for compliance and investigating complaints submitted through its online portal, a spokesman said. Should the agency conclude seroquel advertisement a hospital is noncompliant, it may request a corrective action plan from the hospital and assess a civil monetary penalty not to exceed $300 a day.In a letter issued Jan. 7 to Health and Human Services Secretary Alex Azar, the AHA urged the federal government to exercise enforcement discretion with respect to the price transparency rule as hospitals contend with antidepressant drugs.Following the federal appeals seroquel advertisement court decision in the legal case, Levin said the AHA is reviewing recent measures and determining whether there are any next steps and what they may be.

The organization is also keeping a close eye on actions taken by the incoming Biden-Harris administration..

As antidepressant drugs cases soar and treatment rollout seroquel 50mg cost evolves, hospitals are also working to comply with a federal price transparency rule that took effect on Jan. 1.The American Hospital Association (AHA) has argued that the rule – which requires hospitals to post the prices insurers actually pay for services – will harm hospital negotiations with insurers, seroquel 50mg cost require vast resources to implement, and yield little benefit for consumers. But a federal appeals court in December ruled against the group's seroquel 50mg cost legal challenge, and now hospitals across the country are working to comply. The Centers for Medicare and Medicaid Services (CMS) and staunch supporters of the rule say that it's a critical new step towards driving down out-of-control healthcare costs.The rule requires hospitals to post prices online for 300 shoppable services.

Seventy of those are mandated seroquel 50mg cost by CMS. They range from new patient visits and kidney function lab tests to seroquel 50mg cost MRI scans of the brain, major joint replacement, and cardiothoracic procedures for patients with comorbidities.Prices must be provided in a machine-readable file and a display that's consumer-friendly.Hospitals' PerspectiveThe AHA said it supports the goal of increasing price transparency, but through improving access to out-of-pocket estimates that are more beneficial to consumers than privately negotiated prices. It said that posting such prices can be confusing to patients and harm the marketplace."We worry about the anticompetitive actions that could be a fallout of these numbers," Ariel Levin, senior associate director for policy at the AHA, told MedPage Today.Levin also said that complying with the rule is a huge amount of work for hospitals that are simultaneously seroquel 50mg cost stretching their resources to the brink in the battle against antidepressant drugs.In an amicus brief filed in July, 40 state hospital associations detailed their support for the national group in its ultimately unsuccessful legal challenge to the rule. One Ohio hospital system stated that producing and updating the required data would cost as much as $2 million annually, and that the number of data points it would need to post exceeded 210 million.

Other hospitals noted they would have to hire outside consultants at a cost of $100,000 or more to seroquel 50mg cost help with the process, and that resources for day-to-day operations were already tight."Those are time and financial resources that could be put to better use elsewhere," Levin said. Some of the same staff now preparing hospitals for surge capacity and tracking treatment rollout – such as finance and seroquel 50mg cost information technology employees – are also working on complying with the price transparency rule, she said.Richard Miller, executive vice president and chief business strategy officer at Northwell Health in New York, said that complying with the rule's requirements does demand significant resources initially and on an ongoing basis."It certainly is a large undertaking," Miller said. "We have 19 hospitals in our system and a pretty extensive list of services that we offer."Northwell first put a price estimator tool on its website 10 years ago, he said. Since that time, patient surveys have indicated that out-of-pocket cost estimates continue to be of interest to consumers, especially with the rise seroquel 50mg cost of high-deductible plans.The health system's latest consumer-shoppable tool in compliance with the price transparency rule went live in December, Miller said.

The health system invested a few million dollars in it, he said, and the total investment in making the required machine-readable files is still being determined."While we have been working diligently to serve our communities through the seroquel's latest surge, including vaccinating seroquel 50mg cost our frontline caregivers, we also have been preparing for the new hospital price transparency requirements," a spokesman for Nashville-based HCA Healthcare said. "That includes posting machine-readable files containing the required rate and charge information and providing a patient payment estimator tool on the 'patients and seroquel 50mg cost visitors' and 'patient financial' sections of our hospital websites."A spokeswoman for RWJBarnabas Health in New Jersey said that the health system has established an online resource for members of the public, and that, in accordance with the new rule, it is continuing to update information contained within its website.Will Policy Drive Down Costs?. Caitlin Donovan, senior director of public relations at the National Patient Advocate Foundation, said that the organization supports the new rule as part of broader efforts to help address what patients pay for care.Healthcare costs in the U.S. Are "wildly out of line," Donovan said.The rule is well-suited for consumers needing seroquel 50mg cost procedures such as X-rays and imaging, she said.

That would involve looking at prices for seroquel 50mg cost one procedure at a few different in-network facilities.Navigating price postings may prove challenging for consumers in need of more complex services, Donovan said. Other potential challenges include that a patient may not be able to make a decision about where they receive care because of their medical condition, constraints by their insurer, or their focus on perceived value of care and convenience over cost.Patients may be taking more time with decisions about elective procedures during the seroquel, but they may be sicker when they do seek services, Donovan said, which could be a hindrance to using the price postings.Overall, the rule stands to make consumers more familiar with the concept of shopping around for services in advance, she said. "People like us who have case managers who may be working to negotiate down bills, we may be able to use [the posted prices] on behalf of patients," she added.Though hospitals and other health professionals have questioned how often consumers will use the new price postings to shop for care, it's not only about the numbers, supporters of the rule hold.Marty Makary, MD, MPH, of Johns Hopkins University in Baltimore and editor-in-chief of MedPage Today, said that the argument that people don't use pricing information seroquel 50mg cost when determining where to seek services isn't focusing on the right question. Proxy shoppers, including employers and consumers who may pay seroquel 50mg cost out-of-pocket for care, can drive the marketplace, he said.Makary pointed to the example of two hospitals in the same area that provide the same quality of care charging drastically different prices for delivering a baby."Billing quality is medical quality.

Financial toxicity seroquel 50mg cost is a medical complication," he said. "Taking care of a patient means taking care of the whole person."CMS said it expects the rule to help to increase market competition and ultimately drive down the cost of healthcare services for patients.Now that the rule has taken effect, CMS is auditing a sample of hospitals for compliance and investigating complaints submitted through its online portal, a spokesman said. Should the agency conclude a hospital is noncompliant, it may request a corrective action plan from seroquel 50mg cost the hospital and assess a civil monetary penalty not to exceed $300 a day.In a letter issued Jan. 7 to Health and Human Services Secretary Alex Azar, the AHA urged the federal government to exercise enforcement discretion with respect to the price transparency rule as hospitals contend with antidepressant drugs.Following the federal appeals court decision in the legal case, Levin said the AHA is reviewing recent measures and determining whether there are any next steps and seroquel 50mg cost what they may be.

The organization is also keeping a close eye on actions taken by the incoming Biden-Harris administration..

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